Setting description

TC1 more effective in the TP53- & AR- biomarker signature

Simulations setting

Survival curves (by signature)


PFS distributions (by signature)


Treatment effects (by signature)

signature var Other TC1 TC2 TC3 TC4 TC5
all param scale = 0.112, shape = 1.05 scale = 0.073, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
all summary mean = 8.8, median = 6.3 mean = 13.5, median = 9.7 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
all effect af = 1, hr = 1 af = 1.54, hr = 0.64 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
AR- & TP53- param scale = 0.112, shape = 1.05 scale = 0.042, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
AR- & TP53- summary mean = 8.8, median = 6.3 mean = 23.4, median = 16.9 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
AR- & TP53- effect af = 1, hr = 1 af = 2.67, hr = 0.36 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
HRD+ param scale = 0.112, shape = 1.05 scale = 0.063, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
HRD+ summary mean = 8.8, median = 6.3 mean = 15.6, median = 11.2 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
HRD+ effect af = 1, hr = 1 af = 1.78, hr = 0.55 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
TP53+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
TP53+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
TP53+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
TEfus+ param scale = 0.112, shape = 1.05 scale = 0.09, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
TEfus+ summary mean = 8.8, median = 6.3 mean = 10.9, median = 7.8 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
TEfus+ effect af = 1, hr = 1 af = 1.23, hr = 0.8 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
PI3K+ param scale = 0.112, shape = 1.05 scale = 0.085, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
PI3K+ summary mean = 8.8, median = 6.3 mean = 11.5, median = 8.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
PI3K+ effect af = 1, hr = 1 af = 1.31, hr = 0.75 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1



Survival curves (by subgroup)


PFS distributions (by subgroup)


Treatment effects (by subgroup)

subtype var Other TC1 TC2 TC3 TC4 TC5
—– param scale = 0.112, shape = 1.05 scale = 0.042, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
—– summary mean = 8.8, median = 6.3 mean = 23.4, median = 16.9 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
—– effect af = 1, hr = 1 af = 2.67, hr = 0.36 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
—-+ param scale = 0.112, shape = 1.05 scale = 0.042, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
—-+ summary mean = 8.8, median = 6.3 mean = 23.4, median = 16.9 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
—-+ effect af = 1, hr = 1 af = 2.67, hr = 0.36 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
—+- param scale = 0.112, shape = 1.05 scale = 0.042, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
—+- summary mean = 8.8, median = 6.3 mean = 23.4, median = 16.9 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
—+- effect af = 1, hr = 1 af = 2.67, hr = 0.36 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
—++ param scale = 0.112, shape = 1.05 scale = 0.042, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
—++ summary mean = 8.8, median = 6.3 mean = 23.4, median = 16.9 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
—++ effect af = 1, hr = 1 af = 2.67, hr = 0.36 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–+– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
–+– summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
–+– effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–+-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
–+-+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
–+-+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
–++- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
–++- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–+++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
–+++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
–+++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+— param scale = 0.112, shape = 1.05 scale = 0.042, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
-+— summary mean = 8.8, median = 6.3 mean = 23.4, median = 16.9 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
-+— effect af = 1, hr = 1 af = 2.67, hr = 0.36 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+–+ param scale = 0.112, shape = 1.05 scale = 0.042, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
-+–+ summary mean = 8.8, median = 6.3 mean = 23.4, median = 16.9 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
-+–+ effect af = 1, hr = 1 af = 2.67, hr = 0.36 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+-+- param scale = 0.112, shape = 1.05 scale = 0.042, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
-+-+- summary mean = 8.8, median = 6.3 mean = 23.4, median = 16.9 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
-+-+- effect af = 1, hr = 1 af = 2.67, hr = 0.36 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+-++ param scale = 0.112, shape = 1.05 scale = 0.042, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
-+-++ summary mean = 8.8, median = 6.3 mean = 23.4, median = 16.9 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
-+-++ effect af = 1, hr = 1 af = 2.67, hr = 0.36 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-++– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
-++– summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
-++– effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-++-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
-++-+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
-++-+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
-+++- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
-+++- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-++++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
-++++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
-++++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+—- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+—- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+—- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+—+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+—+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+—+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+–+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+–+- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+–+- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+–++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+–++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+–++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-+– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+-+– summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+-+– effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-+-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+-+-+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+-+-+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+-++- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+-++- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-+++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+-+++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+-+++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++— param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
++— summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
++— effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++–+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
++–+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
++–+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++-+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
++-+- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
++-+- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++-++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
++-++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
++-++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+++– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+++– summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+++– effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+++-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+++-+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+++-+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
++++- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
++++- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+++++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+++++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+++++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1

Errors and power


graduation (counts and proportions):
TC1 TC2 TC3 TC4 TC5
all 52 4 4 1 2
AR- & TP53- 357 3 2 3 1
HRD+ 26 3 3 2 0
TP53+ 3 6 5 3 6
TEfus+ 5 2 4 1 3
PI3K+ 19 2 2 1 0
TC1 TC2 TC3 TC4 TC5
all 0.104 0.008 0.008 0.002 0.004
AR- & TP53- 0.714 0.006 0.004 0.006 0.002
HRD+ 0.052 0.006 0.006 0.004 0.000
TP53+ 0.006 0.012 0.010 0.006 0.012
TEfus+ 0.010 0.004 0.008 0.002 0.006
PI3K+ 0.038 0.004 0.004 0.002 0.000
futility (counts and proportions):
TC1 TC2 TC3 TC4 TC5
all 1 7 3 5 1
AR- & TP53- 1 235 243 218 241
HRD+ 0 47 66 55 29
TP53+ 34 43 26 24 42
TEfus+ 4 21 21 18 18
PI3K+ 3 46 39 43 66
TC1 TC2 TC3 TC4 TC5
all 0.002 0.014 0.006 0.010 0.002
AR- & TP53- 0.002 0.470 0.486 0.436 0.482
HRD+ 0.000 0.094 0.132 0.110 0.058
TP53+ 0.068 0.086 0.052 0.048 0.084
TEfus+ 0.008 0.042 0.042 0.036 0.036
PI3K+ 0.006 0.092 0.078 0.086 0.132
max sample size (counts and proportions):
TC1 TC2 TC3 TC4 TC5
all 0 0 0 0 0
AR- & TP53- 106 39 60 77 57
HRD+ 0 0 0 0 0
TP53+ 0 0 0 0 0
TEfus+ 0 0 0 0 0
PI3K+ 0 0 0 0 0
TC1 TC2 TC3 TC4 TC5
all 0.000 0.000 0.00 0.000 0.000
AR- & TP53- 0.212 0.078 0.12 0.154 0.114
HRD+ 0.000 0.000 0.00 0.000 0.000
TP53+ 0.000 0.000 0.00 0.000 0.000
TEfus+ 0.000 0.000 0.00 0.000 0.000
PI3K+ 0.000 0.000 0.00 0.000 0.000


Operating characteristics

char overall TC1 TC2 TC3 TC4 TC5
err_sign 0.2104208 0.1042084 0.0380762 0.0360721 0.0220441 0.0220441
err_type 0.3046092 0.2084168 0.0380762 0.0360721 0.0220441 0.0220441
pow_sign 0.7154309 0.7154309 0.0000000 0.0000000 0.0000000 0.0000000
pow_type 0.7895792 0.7895792 0.0000000 0.0000000 0.0000000 0.0000000

Median results at the end of the trial

By signature:
signature var Control TC1 TC2 TC3 TC4 TC5
all graduation 0 52 4 4 1 2
all futility 0 1 7 3 5 1
all max_n 0 0 0 0 0 0
all n 393 (359, 422) 123 (51, 233) 152 (101, 218) 146 (96, 219) 151 (97, 226) 148 (102, 224)
all n_unique 364 (334, 392) 114 (46, 219) 137 (92, 204) 134 (86, 204) 138 (88, 213) 134 (93, 210)
all time_trial 36 (36, 36) 36 (7, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
all time_stop NA (NA, NA) 5 (3, 6) 7 (4, 30) 8 (6, 18) 14 (8, 24) 7 (5, 11)
all post_p NA (NA, NA) 1 (0.69, 1) 0.01 (0, 0.15) 0.01 (0, 0.14) 0.01 (0, 0.16) 0.01 (0, 0.13)
all rate 0.087 (0.079, 0.094) 0.063 (0.051, 0.08) 0.113 (0.1, 0.13) 0.113 (0.101, 0.128) 0.113 (0.1, 0.128) 0.113 (0.101, 0.129)
AR- & TP53- graduation 0 357 3 2 3 1
AR- & TP53- futility 0 1 235 243 218 241
AR- & TP53- max_n 0 106 39 60 77 57
AR- & TP53- n 245 (216, 270) 44 (25, 154) 70 (29, 144) 71 (28, 151) 76 (31, 153) 70 (29, 151)
AR- & TP53- n_unique 230 (203, 253) 42 (24, 147) 62 (27, 135) 65 (26, 141) 69 (28, 144) 63 (28, 141)
AR- & TP53- time_trial 36 (36, 36) 12 (6, 36) 36 (15, 36) 36 (14, 36) 36 (15, 36) 36 (14, 36)
AR- & TP53- time_stop NA (NA, NA) 9 (6, 24) 23 (13, 34) 21 (12, 32) 21 (12, 34) 21 (12, 31)
AR- & TP53- post_p NA (NA, NA) 1 (0.98, 1) 0.01 (0, 0.09) 0.01 (0, 0.08) 0.01 (0, 0.08) 0.01 (0, 0.08)
AR- & TP53- rate 0.074 (0.066, 0.083) 0.041 (0.032, 0.05) 0.115 (0.097, 0.142) 0.114 (0.099, 0.14) 0.113 (0.098, 0.139) 0.113 (0.098, 0.142)
HRD+ graduation 0 26 3 3 2 0
HRD+ futility 0 0 47 66 55 29
HRD+ max_n 0 0 0 0 0 0
HRD+ n 61 (49, 73) 15 (3, 30) 27 (14, 43) 29 (19, 46) 30 (19, 49) 26 (14, 42)
HRD+ n_unique 56 (44, 68) 13 (3, 28) 25 (12, 39) 26 (17, 42) 27 (17, 44) 24 (13, 38)
HRD+ time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (31, 36) 36 (34, 36) 36 (36, 36)
HRD+ time_stop NA (NA, NA) 24 (20, 34) 30 (23, 35) 27 (20, 34) 28 (21, 34) 30 (23, 36)
HRD+ post_p NA (NA, NA) 0.78 (0.27, 0.99) 0.18 (0.03, 0.53) 0.16 (0.03, 0.53) 0.16 (0.02, 0.53) 0.18 (0.03, 0.55)
HRD+ rate 0.083 (0.066, 0.1) 0.068 (0.041, 0.122) 0.115 (0.088, 0.159) 0.114 (0.09, 0.148) 0.115 (0.09, 0.155) 0.114 (0.088, 0.156)
TP53+ graduation 0 3 6 5 3 6
TP53+ futility 0 34 43 26 24 42
TP53+ max_n 0 0 0 0 0 0
TP53+ n 121 (105, 140) 56 (18, 78) 61 (37, 85) 57 (37, 80) 58 (37, 80) 61 (38, 82)
TP53+ n_unique 110 (95, 128) 51 (15, 71) 56 (34, 78) 52 (33, 72) 53 (34, 73) 55 (34, 75)
TP53+ time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
TP53+ time_stop NA (NA, NA) 18 (13, 28) 18 (12, 28) 23 (15, 31) 21 (16, 30) 18 (12, 32)
TP53+ post_p NA (NA, NA) 0.5 (0.12, 0.87) 0.48 (0.11, 0.91) 0.5 (0.12, 0.88) 0.49 (0.11, 0.88) 0.48 (0.09, 0.88)
TP53+ rate 0.112 (0.1, 0.13) 0.113 (0.093, 0.14) 0.114 (0.093, 0.14) 0.113 (0.092, 0.14) 0.115 (0.095, 0.141) 0.115 (0.097, 0.144)
TEfus+ graduation 0 5 2 4 1 3
TEfus+ futility 0 4 21 21 18 18
TEfus+ max_n 0 0 0 0 0 0
TEfus+ n 116 (99, 133) 46 (13, 66) 61 (41, 81) 56 (36, 74) 56 (38, 76) 57 (39, 77)
TEfus+ n_unique 106 (91, 123) 41 (12, 60) 55 (38, 75) 50 (32, 67) 51 (34, 71) 53 (35, 69)
TEfus+ time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
TEfus+ time_stop NA (NA, NA) 25 (19, 31) 22 (13, 33) 23 (14, 31) 21 (18, 31) 23 (13, 31)
TEfus+ post_p NA (NA, NA) 0.69 (0.22, 0.98) 0.26 (0.04, 0.7) 0.25 (0.04, 0.71) 0.26 (0.03, 0.69) 0.23 (0.03, 0.72)
TEfus+ rate 0.098 (0.085, 0.114) 0.091 (0.065, 0.119) 0.114 (0.093, 0.135) 0.113 (0.093, 0.14) 0.114 (0.094, 0.139) 0.115 (0.094, 0.142)
PI3K+ graduation 0 19 2 2 1 0
PI3K+ futility 0 3 46 39 43 66
PI3K+ max_n 0 0 0 0 0 0
PI3K+ n 123 (107, 143) 43 (12, 68) 57 (32, 81) 55 (32, 78) 56 (34, 79) 60 (36, 83)
PI3K+ n_unique 113 (98, 131) 39 (11, 63) 51 (30, 74) 50 (29, 71) 52 (30, 74) 56 (33, 76)
PI3K+ time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (27, 36)
PI3K+ time_stop NA (NA, NA) 20 (12, 31) 24 (17, 33) 24 (16, 31) 25 (18, 34) 17 (11, 32)
PI3K+ post_p NA (NA, NA) 0.81 (0.26, 0.99) 0.2 (0.02, 0.6) 0.18 (0.02, 0.63) 0.2 (0.02, 0.65) 0.17 (0.02, 0.57)
PI3K+ rate 0.094 (0.082, 0.11) 0.081 (0.058, 0.109) 0.113 (0.095, 0.141) 0.115 (0.093, 0.141) 0.113 (0.094, 0.142) 0.114 (0.097, 0.143)


By subgroup combinations:
subtype var Control TC1 TC2 TC3 TC4 TC5
—– graduation 0 390 7 6 4 3
—– futility 0 2 238 244 220 241
—– max_n 0 106 39 60 77 57
—– n 145 (123, 166) 32 (19, 109) 24 (10, 82) 27 (8, 93) 30 (8, 97) 26 (8, 91)
—– n_unique 137 (115, 157) 31 (17, 105) 22 (9, 79) 25 (7, 90) 28 (7, 92) 24 (7, 86)
—– post_p NA (NA, NA) 1 (0.93, 1) 0.06 (0, 0.27) 0.06 (0, 0.29) 0.06 (0, 0.27) 0.06 (0, 0.3)
—– rate 0.074 (0.065, 0.085) 0.042 (0.032, 0.053) 0.12 (0.094, 0.173) 0.116 (0.093, 0.177) 0.115 (0.093, 0.177) 0.117 (0.092, 0.17)
—-+ graduation 0 388 8 8 5 3
—-+ futility 0 4 250 250 232 262
—-+ max_n 0 106 39 59 77 56
—-+ n 32 (24, 42) 5 (2, 21) 10 (3, 24) 9 (3, 25) 9 (3, 25) 10 (5, 26)
—-+ n_unique 30 (22, 39) 5 (2, 20) 9 (3, 22) 8 (3, 23) 8 (3, 23) 9 (5, 25)
—-+ post_p NA (NA, NA) 0.87 (0.5, 0.99) 0.23 (0.07, 0.56) 0.22 (0.07, 0.49) 0.24 (0.07, 0.56) 0.22 (0.06, 0.59)
—-+ rate 0.074 (0.054, 0.1) 0.041 (0.019, 0.082) 0.124 (0.081, 0.256) 0.128 (0.086, 0.248) 0.128 (0.08, 0.259) 0.118 (0.081, 0.204)
—+- graduation 0 386 9 8 5 5
—+- futility 0 6 238 246 221 245
—+- max_n 0 106 39 60 77 57
—+- n 5 (2, 9) 1 (0, 4) 3 (0, 6) 2 (0, 6) 2 (0, 6) 2 (0, 5)
—+- n_unique 5 (2, 8) 1 (0, 3) 3 (0, 5) 2 (0, 5) 2 (0, 5) 2 (0, 5)
—+- post_p NA (NA, NA) 0.63 (0.4, 0.86) 0.41 (0.24, 0.65) 0.42 (0.24, 0.64) 0.41 (0.26, 0.66) 0.43 (0.28, 0.63)
—+- rate 0.075 (0.027, 0.177) 0.045 (0, 0.172) 0.127 (0.054, 0.396) 0.143 (0.051, 0.398) 0.137 (0.049, 0.535) 0.132 (0.051, 0.408)
—++ graduation 0 385 10 10 6 5
—++ futility 0 7 250 252 233 265
—++ max_n 0 106 39 59 77 56
—++ n 14 (9, 20) 2 (0, 8) 5 (1, 13) 5 (1, 12) 5 (1, 12) 6 (2, 13)
—++ n_unique 13 (8, 19) 2 (0, 8) 4 (1, 12) 4 (1, 11) 5 (1, 12) 5 (2, 12)
—++ post_p NA (NA, NA) 0.73 (0.39, 0.94) 0.35 (0.15, 0.63) 0.35 (0.16, 0.64) 0.37 (0.18, 0.65) 0.34 (0.15, 0.62)
—++ rate 0.076 (0.048, 0.119) 0.048 (0.012, 0.141) 0.127 (0.072, 0.357) 0.134 (0.07, 0.381) 0.127 (0.066, 0.293) 0.125 (0.075, 0.303)
–+– graduation 0 55 10 9 4 8
–+– futility 0 35 47 28 28 43
–+– max_n 0 0 0 0 0 0
–+– n 26 (19, 35) 10 (3, 24) 11 (4, 23) 10 (4, 23) 10 (4, 21) 10 (4, 22)
–+– n_unique 23 (16, 33) 9 (3, 22) 10 (3, 21) 9 (3, 22) 9 (3, 20) 9 (3, 21)
–+– post_p NA (NA, NA) 0.46 (0.16, 0.83) 0.47 (0.16, 0.85) 0.45 (0.16, 0.83) 0.46 (0.18, 0.85) 0.45 (0.17, 0.85)
–+– rate 0.113 (0.084, 0.156) 0.124 (0.081, 0.244) 0.123 (0.082, 0.255) 0.125 (0.08, 0.279) 0.122 (0.084, 0.259) 0.124 (0.081, 0.266)
–+-+ graduation 0 74 12 11 5 8
–+-+ futility 0 36 75 58 63 92
–+-+ max_n 0 0 0 0 0 0
–+-+ n 24 (18, 33) 8 (2, 20) 9 (3, 21) 9 (3, 22) 10 (4, 22) 11 (5, 23)
–+-+ n_unique 23 (16, 30) 7 (2, 18) 8 (3, 19) 9 (3, 20) 10 (3, 20) 10 (4, 21)
–+-+ post_p NA (NA, NA) 0.46 (0.17, 0.82) 0.47 (0.18, 0.85) 0.46 (0.18, 0.85) 0.49 (0.17, 0.85) 0.45 (0.16, 0.82)
–+-+ rate 0.115 (0.086, 0.157) 0.129 (0.077, 0.282) 0.121 (0.077, 0.245) 0.125 (0.076, 0.256) 0.121 (0.08, 0.243) 0.123 (0.088, 0.249)
–++- graduation 0 60 12 12 5 10
–++- futility 0 37 62 46 42 54
–++- max_n 0 0 0 0 0 0
–++- n 7 (4, 11) 3 (0, 7) 4 (1, 9) 3 (1, 7) 3 (1, 6) 3 (1, 7)
–++- n_unique 6 (3, 10) 3 (0, 7) 4 (1, 8) 3 (1, 6) 3 (1, 6) 3 (1, 6)
–++- post_p NA (NA, NA) 0.46 (0.25, 0.78) 0.47 (0.25, 0.77) 0.48 (0.28, 0.73) 0.48 (0.26, 0.77) 0.48 (0.27, 0.76)
–++- rate 0.116 (0.064, 0.211) 0.132 (0.061, 0.369) 0.122 (0.061, 0.31) 0.122 (0.057, 0.381) 0.131 (0.052, 0.389) 0.132 (0.057, 0.454)
–+++ graduation 0 78 14 14 6 10
–+++ futility 0 38 88 70 73 99
–+++ max_n 0 0 0 0 0 0
–+++ n 19 (13, 26) 7 (2, 17) 8 (3, 18) 7 (3, 16) 7 (3, 16) 9 (4, 18)
–+++ n_unique 18 (12, 24) 6 (1, 15) 7 (3, 16) 6 (2, 14) 7 (2, 15) 8 (3, 17)
–+++ post_p NA (NA, NA) 0.48 (0.2, 0.83) 0.44 (0.18, 0.84) 0.46 (0.19, 0.83) 0.45 (0.2, 0.82) 0.45 (0.16, 0.82)
–+++ rate 0.113 (0.084, 0.161) 0.121 (0.071, 0.274) 0.124 (0.079, 0.275) 0.127 (0.075, 0.344) 0.13 (0.078, 0.327) 0.127 (0.081, 0.272)
-+— graduation 0 394 10 9 6 3
-+— futility 0 2 259 262 249 251
-+— max_n 0 102 37 59 76 56
-+— n 27 (19, 36) 3 (0, 16) 9 (3, 22) 10 (4, 24) 10 (5, 23) 9 (3, 21)
-+— n_unique 25 (18, 34) 2 (0, 14) 8 (2, 21) 9 (4, 22) 9 (4, 22) 8 (2, 20)
-+— post_p NA (NA, NA) 0.81 (0.4, 0.98) 0.27 (0.09, 0.55) 0.26 (0.09, 0.57) 0.25 (0.08, 0.59) 0.27 (0.1, 0.58)
-+— rate 0.075 (0.054, 0.104) 0.043 (0.016, 0.143) 0.121 (0.084, 0.27) 0.118 (0.081, 0.229) 0.121 (0.078, 0.222) 0.121 (0.079, 0.266)
-+–+ graduation 0 392 10 11 7 3
-+–+ futility 0 4 271 268 259 269
-+–+ max_n 0 102 37 58 76 55
-+–+ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-+–+ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-+–+ post_p NA (NA, NA) 0.49 (0.49, 0.49) 0.5 (0.44, 0.54) 0.49 (0.49, 0.49) 0.5 (0.49, 0.51) 0.5 (0.48, 0.52)
-+–+ rate 0.246 (0, 0.922) 0.15 (0.03, 0.269) 0.081 (0, 0.478) 0.195 (0, 0.475) 0.14 (0, 1.835) 0.136 (0.037, 0.242)
-+-+- graduation 0 390 12 11 7 5
-+-+- futility 0 6 259 263 250 254
-+-+- max_n 0 102 37 59 76 56
-+-+- n 13 (8, 19) 1 (0, 6) 5 (1, 12) 5 (2, 12) 5 (2, 12) 5 (1, 11)
-+-+- n_unique 12 (7, 18) 1 (0, 6) 4 (1, 11) 5 (2, 11) 5 (2, 11) 4 (1, 10)
-+-+- post_p NA (NA, NA) 0.73 (0.4, 0.94) 0.35 (0.16, 0.65) 0.34 (0.16, 0.67) 0.34 (0.16, 0.67) 0.37 (0.19, 0.69)
-+-+- rate 0.075 (0.046, 0.121) 0.048 (0.008, 0.17) 0.128 (0.071, 0.333) 0.127 (0.072, 0.327) 0.132 (0.076, 0.336) 0.131 (0.065, 0.378)
-+-++ graduation 0 389 12 13 8 5
-+-++ futility 0 7 271 269 260 271
-+-++ max_n 0 102 37 58 76 55
-+-++ n 5 (2, 8) 0 (0, 3) 2 (0, 5) 2 (0, 6) 3 (1, 7) 2 (0, 5)
-+-++ n_unique 5 (2, 8) 0 (0, 3) 2 (0, 5) 2 (0, 5) 3 (1, 6) 2 (0, 5)
-+-++ post_p NA (NA, NA) 0.6 (0.37, 0.82) 0.42 (0.24, 0.64) 0.42 (0.26, 0.66) 0.43 (0.27, 0.67) 0.43 (0.28, 0.67)
-+-++ rate 0.078 (0.03, 0.172) 0.048 (0, 0.237) 0.139 (0.058, 0.473) 0.127 (0.053, 0.422) 0.129 (0.058, 0.399) 0.129 (0.051, 0.424)
-++– graduation 0 81 13 10 6 8
-++– futility 0 33 89 91 81 69
-++– max_n 0 0 0 0 0 0
-++– n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-++– n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-++– post_p NA (NA, NA) 0.5 (0.45, 0.58) 0.49 (0.49, 0.49) 0.49 (0.46, 0.52) 0.49 (0.47, 0.52) 0.52 (0.44, 0.54)
-++– rate 0.103 (0, 0.505) 0.102 (0, 0.516) 0.048 (0, 0.303) 0.152 (0.061, 1.178) 0.168 (0, 0.823) 0.131 (0, 0.523)
-++-+ graduation 0 100 14 12 7 8
-++-+ futility 0 34 115 117 113 111
-++-+ max_n 0 0 0 0 0 0
-++-+ n 2 (0, 5) 1 (0, 3) 1 (0, 4) 2 (0, 4) 2 (0, 4) 1 (0, 3)
-++-+ n_unique 2 (0, 5) 1 (0, 3) 1 (0, 3) 1 (0, 4) 1 (0, 4) 1 (0, 3)
-++-+ post_p NA (NA, NA) 0.48 (0.34, 0.68) 0.48 (0.32, 0.73) 0.46 (0.3, 0.71) 0.47 (0.3, 0.69) 0.5 (0.33, 0.69)
-++-+ rate 0.126 (0.043, 0.4) 0.133 (0.039, 0.597) 0.133 (0.021, 0.501) 0.145 (0.047, 0.573) 0.143 (0.042, 0.523) 0.129 (0, 0.603)
-+++- graduation 0 86 15 13 7 10
-+++- futility 0 35 102 104 94 78
-+++- max_n 0 0 0 0 0 0
-+++- n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-+++- n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-+++- post_p NA (NA, NA) 0.41 (0.41, 0.41) 0.53 (0.49, 0.6) 0.51 (0.48, 0.55) 0.44 (0.42, 0.52) 0.45 (0.45, 0.45)
-+++- rate 0.144 (0, 4.648) 0.395 (0.177, 1.86) 0.083 (0, 0.645) 0.129 (0.051, 1.96) 0.149 (0, 0.575) 0.138 (0, 0.654)
-++++ graduation 0 104 16 15 8 10
-++++ futility 0 36 127 126 122 116
-++++ max_n 0 0 0 0 0 0
-++++ n 3 (1, 5) 1 (0, 3) 1 (0, 4) 2 (0, 4) 2 (0, 4) 1 (0, 3)
-++++ n_unique 2 (0, 5) 1 (0, 3) 1 (0, 3) 2 (0, 4) 2 (0, 4) 1 (0, 3)
-++++ post_p NA (NA, NA) 0.47 (0.33, 0.69) 0.47 (0.32, 0.69) 0.49 (0.3, 0.72) 0.49 (0.32, 0.68) 0.47 (0.32, 0.66)
-++++ rate 0.116 (0.033, 0.39) 0.13 (0.031, 0.626) 0.144 (0.027, 0.647) 0.128 (0.038, 0.481) 0.129 (0.044, 0.424) 0.141 (0.044, 0.603)
+—- graduation 0 52 4 4 1 2
+—- futility 0 1 7 3 5 1
+—- max_n 0 0 0 0 0 0
+—- n 5 (2, 8) 2 (0, 5) 3 (1, 7) 2 (0, 5) 2 (1, 5) 2 (1, 5)
+—- n_unique 4 (1, 8) 2 (0, 5) 3 (1, 6) 2 (0, 5) 2 (0, 5) 2 (1, 5)
+—- post_p NA (NA, NA) 0.45 (0.29, 0.72) 0.47 (0.28, 0.75) 0.48 (0.3, 0.76) 0.47 (0.3, 0.75) 0.5 (0.31, 0.75)
+—- rate 0.119 (0.055, 0.256) 0.146 (0.051, 0.549) 0.132 (0.053, 0.377) 0.129 (0.045, 0.448) 0.136 (0.043, 0.458) 0.125 (0.045, 0.43)
+—+ graduation 0 71 6 6 2 2
+—+ futility 0 4 50 41 48 66
+—+ max_n 0 0 0 0 0 0
+—+ n 2 (0, 4) 1 (0, 3) 1 (0, 3) 1 (0, 3) 1 (0, 3) 1 (0, 3)
+—+ n_unique 1 (0, 4) 1 (0, 3) 1 (0, 3) 1 (0, 3) 1 (0, 3) 1 (0, 3)
+—+ post_p NA (NA, NA) 0.49 (0.36, 0.67) 0.49 (0.33, 0.66) 0.48 (0.35, 0.68) 0.48 (0.36, 0.68) 0.48 (0.34, 0.67)
+—+ rate 0.127 (0.035, 0.422) 0.129 (0, 0.543) 0.129 (0, 0.601) 0.127 (0, 0.755) 0.13 (0, 0.679) 0.144 (0.031, 0.628)
+–+- graduation 0 57 6 8 2 5
+–+- futility 0 5 25 23 22 19
+–+- max_n 0 0 0 0 0 0
+–+- n 7 (4, 12) 3 (1, 8) 5 (2, 9) 3 (1, 8) 3 (1, 7) 3 (1, 7)
+–+- n_unique 7 (3, 11) 3 (1, 7) 4 (2, 8) 3 (1, 7) 3 (1, 7) 3 (1, 7)
+–+- post_p NA (NA, NA) 0.46 (0.24, 0.77) 0.48 (0.22, 0.81) 0.48 (0.28, 0.79) 0.46 (0.25, 0.8) 0.44 (0.25, 0.76)
+–+- rate 0.111 (0.063, 0.21) 0.127 (0.061, 0.374) 0.123 (0.066, 0.331) 0.126 (0.058, 0.405) 0.132 (0.054, 0.447) 0.134 (0.061, 0.409)
+–++ graduation 0 75 8 10 3 5
+–++ futility 0 7 64 53 60 76
+–++ max_n 0 0 0 0 0 0
+–++ n 3 (1, 6) 2 (0, 4) 2 (0, 5) 2 (0, 4) 2 (0, 4) 2 (0, 5)
+–++ n_unique 3 (1, 6) 2 (0, 4) 2 (0, 5) 2 (0, 4) 1 (0, 4) 2 (0, 5)
+–++ post_p NA (NA, NA) 0.49 (0.3, 0.69) 0.47 (0.32, 0.74) 0.47 (0.3, 0.73) 0.5 (0.31, 0.73) 0.47 (0.31, 0.73)
+–++ rate 0.122 (0.037, 0.332) 0.129 (0.038, 0.421) 0.125 (0.046, 0.448) 0.134 (0.036, 0.668) 0.124 (0.031, 0.554) 0.133 (0.045, 0.503)
+-+– graduation 0 55 10 9 4 8
+-+– futility 0 35 47 28 28 43
+-+– max_n 0 0 0 0 0 0
+-+– n 1 (0, 3) 1 (0, 2) 1 (0, 2) 1 (0, 2) 1 (0, 2) 1 (0, 2)
+-+– n_unique 1 (0, 3) 1 (0, 2) 1 (0, 2) 1 (0, 2) 1 (0, 2) 1 (0, 2)
+-+– post_p NA (NA, NA) 0.49 (0.39, 0.65) 0.48 (0.35, 0.63) 0.48 (0.37, 0.62) 0.49 (0.37, 0.67) 0.48 (0.39, 0.63)
+-+– rate 0.128 (0, 0.467) 0.129 (0, 0.727) 0.144 (0, 0.76) 0.141 (0, 0.832) 0.139 (0, 0.657) 0.141 (0, 0.585)
+-+-+ graduation 0 74 12 11 5 8
+-+-+ futility 0 36 75 58 63 92
+-+-+ max_n 0 0 0 0 0 0
+-+-+ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+-+-+ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+-+-+ post_p NA (NA, NA) NA (NA, NA) 0.48 (0.48, 0.48) 0.53 (0.5, 0.54) 0.47 (0.45, 0.52) 0.45 (0.44, 0.52)
+-+-+ rate 0.159 (0, 0.723) 0.187 (0, 0.38) 0.091 (0, 0.697) 0.11 (0, 1.446) 0.157 (0, 0.498) 0.152 (0, 0.657)
+-++- graduation 0 60 12 12 5 10
+-++- futility 0 37 62 46 42 54
+-++- max_n 0 0 0 0 0 0
+-++- n 20 (14, 27) 8 (2, 18) 10 (4, 20) 8 (3, 18) 8 (3, 19) 8 (3, 19)
+-++- n_unique 18 (13, 26) 7 (2, 16) 10 (4, 19) 7 (2, 16) 7 (3, 17) 8 (2, 17)
+-++- post_p NA (NA, NA) 0.49 (0.18, 0.83) 0.47 (0.18, 0.87) 0.46 (0.2, 0.82) 0.45 (0.19, 0.82) 0.47 (0.17, 0.85)
+-++- rate 0.115 (0.083, 0.162) 0.125 (0.077, 0.291) 0.122 (0.08, 0.248) 0.125 (0.076, 0.294) 0.128 (0.078, 0.278) 0.125 (0.076, 0.329)
+-+++ graduation 0 78 14 14 6 10
+-+++ futility 0 38 88 70 73 99
+-+++ max_n 0 0 0 0 0 0
+-+++ n 16 (10, 22) 6 (1, 14) 7 (3, 15) 7 (2, 15) 6 (3, 15) 7 (3, 15)
+-+++ n_unique 14 (9, 21) 5 (1, 12) 7 (2, 14) 6 (2, 14) 6 (2, 13) 6 (2, 14)
+-+++ post_p NA (NA, NA) 0.47 (0.2, 0.82) 0.48 (0.21, 0.84) 0.47 (0.22, 0.86) 0.46 (0.2, 0.8) 0.45 (0.19, 0.8)
+-+++ rate 0.111 (0.079, 0.174) 0.129 (0.071, 0.339) 0.122 (0.071, 0.285) 0.12 (0.072, 0.304) 0.131 (0.075, 0.327) 0.125 (0.078, 0.293)
++— graduation 0 78 7 7 3 2
++— futility 0 1 54 69 60 30
++— max_n 0 0 0 0 0 0
++— n 8 (4, 12) 3 (0, 7) 3 (1, 8) 4 (2, 9) 4 (2, 9) 4 (1, 8)
++— n_unique 7 (4, 11) 3 (0, 7) 3 (1, 8) 4 (2, 8) 4 (2, 8) 3 (1, 7)
++— post_p NA (NA, NA) 0.46 (0.26, 0.78) 0.46 (0.27, 0.76) 0.46 (0.24, 0.76) 0.46 (0.23, 0.78) 0.46 (0.27, 0.8)
++— rate 0.112 (0.066, 0.209) 0.134 (0.062, 0.386) 0.131 (0.062, 0.428) 0.134 (0.066, 0.345) 0.13 (0.069, 0.376) 0.134 (0.049, 0.436)
++–+ graduation 0 97 8 9 4 2
++–+ futility 0 4 93 103 99 87
++–+ max_n 0 0 0 0 0 0
++–+ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++–+ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++–+ post_p NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.51 (0.51, 0.51) 0.52 (0.48, 0.55)
++–+ rate 0.173 (0, 1.48) 0 (0, 1.517) 0 (0, 0.185) 0.172 (0, 2.691) 0.151 (0, 0.58) 0.112 (0, 0.6)
++-+- graduation 0 83 9 11 4 5
++-+- futility 0 5 69 84 76 45
++-+- max_n 0 0 0 0 0 0
++-+- n 1 (0, 2) 0 (0, 2) 0 (0, 2) 1 (0, 2) 1 (0, 2) 0 (0, 2)
++-+- n_unique 1 (0, 2) 0 (0, 2) 0 (0, 2) 0 (0, 2) 0 (0, 2) 0 (0, 2)
++-+- post_p NA (NA, NA) 0.49 (0.39, 0.65) 0.49 (0.39, 0.61) 0.5 (0.39, 0.6) 0.48 (0.39, 0.65) 0.48 (0.38, 0.62)
++-+- rate 0.138 (0, 0.639) 0.125 (0, 0.583) 0.141 (0, 0.83) 0.135 (0, 0.946) 0.14 (0, 0.76) 0.151 (0, 0.613)
++-++ graduation 0 101 10 13 5 5
++-++ futility 0 7 106 112 110 94
++-++ max_n 0 0 0 0 0 0
++-++ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++-++ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++-++ post_p NA (NA, NA) 0.55 (0.55, 0.55) 0.43 (0.43, 0.43) 0.52 (0.51, 0.57) 0.48 (0.47, 0.48) 0.42 (0.42, 0.42)
++-++ rate 0.129 (0, 1.03) 0.066 (0, 0.643) 0.188 (0, 0.613) 0.16 (0, 1.287) 0.182 (0.019, 1.281) 0.076 (0, 0.67)
+++– graduation 0 81 13 10 6 8
+++– futility 0 33 89 91 81 69
+++– max_n 0 0 0 0 0 0
+++– n 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1)
+++– n_unique 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1)
+++– post_p NA (NA, NA) 0.5 (0.41, 0.57) 0.53 (0.45, 0.58) 0.5 (0.45, 0.55) 0.49 (0.43, 0.62) 0.47 (0.38, 0.55)
+++– rate 0.135 (0, 0.826) 0.133 (0, 0.571) 0.096 (0, 0.71) 0.125 (0, 1.673) 0.149 (0, 0.919) 0.189 (0, 1.569)
+++-+ graduation 0 100 14 12 7 8
+++-+ futility 0 34 115 117 113 111
+++-+ max_n 0 0 0 0 0 0
+++-+ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++-+ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++-+ post_p NA (NA, NA) 0.44 (0.44, 0.44) NA (NA, NA) 0.52 (0.48, 0.56) NA (NA, NA) 0.53 (0.49, 0.54)
+++-+ rate 0.117 (0, 1.06) 0.162 (0, 1.627) 0.115 (0, 0.485) 0.121 (0, 3.302) 0.193 (0, 0.788) 0.124 (0, 0.527)
++++- graduation 0 86 15 13 7 10
++++- futility 0 35 102 104 94 78
++++- max_n 0 0 0 0 0 0
++++- n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++++- n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++++- post_p NA (NA, NA) 0.5 (0.47, 0.53) 0.52 (0.48, 0.55) 0.44 (0.44, 0.44) 0.46 (0.41, 0.47) 0.45 (0.45, 0.45)
++++- rate 0.212 (0.044, 0.599) 0.089 (0, 0.855) 0.221 (0, 0.592) 0.214 (0, 1.016) 0.198 (0, 2.152) 0.183 (0.035, 1.539)
+++++ graduation 0 104 16 15 8 10
+++++ futility 0 36 127 126 122 116
+++++ max_n 0 0 0 0 0 0
+++++ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++++ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++++ post_p NA (NA, NA) 0.46 (0.42, 0.47) NA (NA, NA) 0.6 (0.6, 0.6) 0.5 (0.47, 0.53) 0.5 (0.47, 0.53)
+++++ rate 0.076 (0, 0.253) 0.126 (0.029, 0.378) 0.115 (0, 0.506) 0.163 (0, 0.585) 0.146 (0, 0.611) 0.148 (0, 0.492)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var TC1 TC2 TC3 TC4 TC5
all count 52 4 4 1 2
all time_stop 5 (3, 6) 6 (5, 7) 6 (6, 8) 8 (8, 8) 6 (5, 7)
all n_trt 32 (25, 41) 30 (26, 32) 28 (26, 34) 43 (43, 43) 29 (26, 32)
all n_control 49 (33, 63) 56 (51, 57) 59 (51, 62) 82 (82, 82) 54 (51, 57)
all post_p 0.92 (0.86, 0.98) 0.92 (0.89, 0.96) 0.91 (0.89, 0.91) 0.92 (0.92, 0.92) 0.89 (0.86, 0.91)
all order 1 (1, 1) 1 (1, 1) 1 (1, 1) 1 (1, 1) 1.5 (1.1, 1.9)
AR- & TP53- count 357 3 2 3 1
AR- & TP53- time_stop 9 (6, 24) 10 (9, 14) 10 (10, 11) 13 (10, 16) 9 (9, 9)
AR- & TP53- n_trt 38 (26, 132) 26 (25, 40) 40 (34, 47) 30 (27, 54) 28 (28, 28)
AR- & TP53- n_control 47 (31, 140) 56 (44, 69) 54 (48, 60) 80 (49, 90) 42 (42, 42)
AR- & TP53- post_p 0.97 (0.89, 1) 0.9 (0.89, 0.92) 0.89 (0.89, 0.9) 0.92 (0.9, 0.96) 0.98 (0.98, 0.98)
AR- & TP53- order 1 (1, 2) 1 (1, 1.8) 2 (1.2, 2.8) 1 (1, 1.8) 1 (1, 1)
HRD+ count 26 3 3 2
HRD+ time_stop 24 (20, 34) 23 (18, 27) 22 (17, 23) 24 (22, 27)
HRD+ n_trt 26 (25, 28) 27 (25, 34) 29 (27, 31) 32 (28, 35)
HRD+ n_control 35 (27, 48) 32 (31, 34) 34 (24, 43) 30 (27, 34)
HRD+ post_p 0.98 (0.9, 1) 0.97 (0.94, 0.98) 0.93 (0.88, 0.97) 0.96 (0.93, 0.99)
HRD+ order 1 (1, 2) 2 (2, 2) 2 (2, 2.8) 1.5 (1.1, 1.9)
TP53+ count 3 6 5 3 6
TP53+ time_stop 17 (14, 24) 12 (11, 16) 15 (11, 18) 17 (15, 22) 14 (11, 25)
TP53+ n_trt 28 (27, 50) 26 (26, 31) 26 (25, 28) 36 (30, 38) 32 (26, 52)
TP53+ n_control 51 (40, 91) 37 (34, 42) 43 (30, 56) 44 (40, 67) 34 (28, 72)
TP53+ post_p 0.98 (0.92, 0.99) 0.96 (0.92, 0.98) 0.96 (0.94, 0.96) 0.97 (0.9, 0.98) 0.96 (0.94, 0.98)
TP53+ order 2 (1.2, 2) 1 (1, 1.5) 2 (1.4, 2.6) 1 (1, 1) 2 (1, 3)
TEfus+ count 5 2 4 1 3
TEfus+ time_stop 21 (17, 29) 12 (11, 13) 16 (14, 17) 16 (16, 16) 13 (11, 13)
TEfus+ n_trt 34 (27, 45) 30 (28, 32) 30 (28, 32) 30 (30, 30) 27 (26, 30)
TEfus+ n_control 56 (41, 89) 30 (24, 35) 38 (28, 46) 36 (36, 36) 26 (26, 32)
TEfus+ post_p 0.98 (0.95, 1) 0.97 (0.97, 0.98) 0.92 (0.87, 0.98) 0.96 (0.96, 0.96) 0.97 (0.92, 0.97)
TEfus+ order 2 (2, 2) 2 (2, 2) 1.5 (1, 2) 1 (1, 1) 2 (1.2, 2)
PI3K+ count 19 2 2 1
PI3K+ time_stop 19 (13, 30) 14 (12, 16) 16 (14, 18) 20 (20, 20)
PI3K+ n_trt 30 (25, 55) 30 (26, 33) 28 (26, 30) 28 (28, 28)
PI3K+ n_control 55 (33, 96) 38 (32, 44) 46 (44, 48) 62 (62, 62)
PI3K+ post_p 0.98 (0.93, 1) 0.97 (0.94, 0.99) 0.92 (0.89, 0.94) 0.99 (0.99, 0.99)
PI3K+ order 2 (1, 2.2) 2 (1.2, 2.8) 2 (2, 2) 1 (1, 1)
Futility:
signature var TC1 TC2 TC3 TC4 TC5
all count 1 7 3 5 1
all time_stop 5 (5, 5) 10 (5, 31) 16 (10, 19) 19 (8, 24) 12 (12, 12)
all n_trt 31 (31, 31) 50 (27, 88) 59 (33, 75) 56 (29, 70) 52 (52, 52)
all n_control 46 (46, 46) 84 (51, 330) 136 (90, 174) 165 (60, 266) 107 (107, 107)
all post_p 0.24 (0.24, 0.24) 0 (0, 0.09) 0 (0, 0.01) 0.01 (0, 0.02) 0 (0, 0)
all order 1 (1, 1) 1 (1, 5.8) 2 (1.2, 2.8) 2 (1, 4.4) 2 (2, 2)
AR- & TP53- count 1 235 243 218 241
AR- & TP53- time_stop 4 (4, 4) 23 (13, 34) 22 (12, 32) 22 (13, 34) 21 (12, 31)
AR- & TP53- n_trt 26 (26, 26) 45 (27, 100) 46 (26, 108) 44 (27, 100) 44 (26, 101)
AR- & TP53- n_control 27 (27, 27) 145 (67, 233) 125 (61, 213) 132 (65, 232) 120 (63, 207)
AR- & TP53- post_p 0.24 (0.24, 0.24) 0.01 (0, 0.1) 0.02 (0, 0.11) 0.02 (0, 0.14) 0.03 (0, 0.15)
AR- & TP53- order 1 (1, 1) 2 (1, 4.6) 2 (1, 4) 2 (1, 4) 2 (1, 4)
HRD+ count 47 66 55 29
HRD+ time_stop 32 (23, 35) 27 (20, 34) 28 (21, 34) 30 (23, 36)
HRD+ n_trt 27 (25, 39) 28 (25, 40) 29 (25, 36) 28 (25, 42)
HRD+ n_control 50 (34, 65) 44 (24, 56) 42 (25, 64) 49 (33, 60)
HRD+ post_p 0.09 (0.02, 0.24) 0.09 (0.03, 0.25) 0.08 (0.01, 0.25) 0.08 (0.04, 0.25)
HRD+ order 3 (2, 6) 3 (2, 5) 3 (1, 5.6) 4 (2, 5)
TP53+ count 34 43 26 24 42
TP53+ time_stop 18 (12, 29) 19 (15, 29) 24 (19, 31) 22 (17, 30) 21 (13, 32)
TP53+ n_trt 28 (25, 43) 32 (25, 50) 32 (26, 44) 31 (25, 42) 31 (25, 49)
TP53+ n_control 54 (37, 90) 60 (38, 104) 76 (51, 112) 61 (45, 105) 62 (37, 111)
TP53+ post_p 0.08 (0.02, 0.17) 0.07 (0.03, 0.19) 0.06 (0.01, 0.2) 0.08 (0.02, 0.21) 0.11 (0.01, 0.25)
TP53+ order 2 (1, 3.7) 2 (1, 3.8) 3 (1, 4.5) 2 (1, 4) 2 (1, 4)
TEfus+ count 4 21 21 18 18
TEfus+ time_stop 26 (24, 33) 22 (15, 33) 24 (16, 32) 22 (19, 31) 24 (13, 31)
TEfus+ n_trt 30 (28, 40) 33 (27, 52) 35 (26, 40) 32 (26, 43) 29 (25, 45)
TEfus+ n_control 84 (79, 122) 74 (37, 107) 74 (42, 98) 61 (46, 111) 72 (36, 118)
TEfus+ post_p 0.05 (0.01, 0.22) 0.04 (0.01, 0.13) 0.02 (0, 0.07) 0.05 (0.01, 0.09) 0.02 (0, 0.13)
TEfus+ order 3.5 (2, 5) 4 (2, 7) 4 (2, 5) 3 (1, 4.3) 4 (1.7, 6)
PI3K+ count 3 46 39 43 66
PI3K+ time_stop 23 (14, 31) 24 (17, 33) 25 (17, 31) 25 (18, 35) 17 (11, 32)
PI3K+ n_trt 28 (26, 33) 32 (25, 52) 30 (25, 49) 34 (26, 52) 33 (26, 54)
PI3K+ n_control 71 (45, 105) 70 (44, 109) 81 (45, 104) 81 (54, 118) 52 (29, 114)
PI3K+ post_p 0.12 (0.08, 0.16) 0.05 (0, 0.12) 0.05 (0, 0.14) 0.03 (0, 0.13) 0.04 (0.01, 0.18)
PI3K+ order 4 (3.2, 4) 3 (1.5, 4) 3 (1.8, 4.2) 3 (1, 6) 2 (1, 5)


By subgroup combinations

Graduation:
signature treatment var —– —-+ —+- —++ –+– –+-+ –++- –+++ -+— -+–+ -+-+- -+-++ -++– -++-+ -+++- -++++ +—- +—+ +–+- +–++ +-+– +-+-+ +-++- +-+++ ++— ++–+ ++-+- ++-++ +++– +++-+ ++++- +++++
all TC1 count 52 52 52 52 52 52 52 52 52 52 52 52 52 52 52 52 52 52 52 52 52 52 52 52 52 52 52 52 52 52 52 52
all TC1 time 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6)
all TC1 n 18 (14, 23) 2 (0, 4) 0 (0, 2) 1 (0, 4) 2 (1, 5) 1 (0, 3) 0 (0, 2) 1 (0, 2) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 2) 0 (0, 1) 0 (0, 1) 0 (0, 0) 1 (0, 2) 0 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 post_p 0.65 (0.55, 0.81) 0.57 (0.51, 0.66) 0.52 (0.5, 0.54) 0.53 (0.51, 0.62) 0.55 (0.51, 0.6) 0.54 (0.51, 0.63) 0.53 (0.51, 0.58) 0.54 (0.51, 0.58) 0.53 (0.52, 0.59) NA (NA, NA) 0.52 (0.51, 0.57) 0.55 (0.52, 0.55) NA (NA, NA) 0.53 (0.53, 0.54) NA (NA, NA) NA (NA, NA) 0.55 (0.51, 0.56) 0.51 (0.5, 0.51) 0.52 (0.5, 0.62) 0.53 (0.53, 0.54) NA (NA, NA) NA (NA, NA) 0.54 (0.51, 0.6) 0.54 (0.51, 0.57) 0.54 (0.53, 0.56) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC1 r_prob 0.41 (0.41, 0.41) 0.22 (0.22, 0.22) 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0.31 (0.31, 0.31) 0.13 (0.13, 0.13) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 rate 0.029 (0, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0.109) 0 (0, 0.11) 0 (0, 0.176) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0 (0, 0.93) 0 (0, 0.117) 0 (0, 0) 0 (0, 0.048) 0 (0, 0.25) 0 (0, 1.516) NA (NA, NA) 0 (0, 0.055) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0.185 (0.185, 0.185) NA (NA, NA) NA (NA, NA)
all TC2 count 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
all TC2 time 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7)
all TC2 n 11 (8, 15) 0 (0, 3) 1 (1, 2) 0 (0, 1) 2 (1, 3) 0 (0, 1) 0 (0, 1) 1 (0, 1) 0 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 1) 1 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 5 (4, 6) 3 (2, 4) 1 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC2 post_p 0.72 (0.57, 0.85) 0.52 (0.51, 0.52) 0.51 (0.51, 0.51) 0.52 (0.52, 0.52) 0.55 (0.51, 0.57) 0.52 (0.52, 0.52) 0.66 (0.66, 0.66) 0.51 (0.51, 0.51) 0.55 (0.53, 0.57) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.51 (0.51, 0.51) NA (NA, NA) 0.56 (0.55, 0.58) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.57 (0.52, 0.65) 0.53 (0.51, 0.59) 0.51 (0.51, 0.51) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC2 r_prob 0.18 (0.18, 0.18) 0.03 (0.03, 0.03) 0.25 (0.25, 0.25) 0.03 (0.03, 0.03) 0.17 (0.17, 0.17) 0.07 (0.07, 0.07) 0.41 (0.41, 0.41) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0.29 (0.29, 0.29) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC2 rate 0.019 (0, 0.075) 0.045 (0.009, 0.081) 0 (0, 0.157) 0 (0, 0) 0 (0, 0.059) 0 (0, 0) 0.115 (0.115, 0.115) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.027 (0, 0.06) 0 (0, 0.076) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC3 count 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
all TC3 time 6 (6, 8) 6 (6, 8) 6 (6, 8) 6 (6, 8) 6 (6, 8) 6 (6, 8) 6 (6, 8) 6 (6, 8) 6 (6, 8) 6 (6, 8) 6 (6, 8) 6 (6, 8) 6 (6, 8) 6 (6, 8) 6 (6, 8) 6 (6, 8) 6 (6, 8) 6 (6, 8) 6 (6, 8) 6 (6, 8) 6 (6, 8) 6 (6, 8) 6 (6, 8) 6 (6, 8) 6 (6, 8) 6 (6, 8) 6 (6, 8) 6 (6, 8) 6 (6, 8) 6 (6, 8) 6 (6, 8) 6 (6, 8)
all TC3 n 6 (4, 10) 2 (1, 3) 0 (0, 1) 0 (0, 1) 2 (1, 3) 2 (1, 3) 0 (0, 0) 0 (0, 1) 7 (4, 8) 0 (0, 0) 1 (0, 3) 0 (0, 1) 0 (0, 0) 0 (0, 2) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 0) 0 (0, 0) 2 (1, 3) 1 (0, 3) 0 (0, 3) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC3 post_p 0.58 (0.55, 0.68) 0.52 (0.51, 0.55) NA (NA, NA) 0.54 (0.54, 0.54) 0.52 (0.51, 0.54) 0.53 (0.52, 0.57) NA (NA, NA) 0.55 (0.52, 0.57) 0.55 (0.52, 0.57) NA (NA, NA) 0.63 (0.63, 0.63) 0.53 (0.53, 0.53) NA (NA, NA) 0.67 (0.67, 0.67) NA (NA, NA) NA (NA, NA) 0.54 (0.54, 0.54) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.62 (0.55, 0.7) 0.53 (0.52, 0.54) 0.55 (0.54, 0.56) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
all TC3 rate 0 (0, 0.05) 0 (0, 0.055) 0 (0, 0) 0 (0, 0) 0.056 (0, 0.166) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0.034 (0.01, 0.042) NA (NA, NA) 0 (0, 0.51) 0.138 (0.138, 0.138) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0.057 (0.011, 0.103) NA (NA, NA) NA (NA, NA) NA (NA, NA) 2.421 (2.421, 2.421) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC4 count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
all TC4 time 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8)
all TC4 n 6 (6, 6) 0 (0, 0) 0 (0, 0) 2 (2, 2) 5 (5, 5) 1 (1, 1) 1 (1, 1) 0 (0, 0) 8 (8, 8) 0 (0, 0) 7 (7, 7) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 1 (1, 1) 1 (1, 1) 0 (0, 0) 0 (0, 0) 6 (6, 6) 2 (2, 2) 3 (3, 3) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC4 post_p 0.55 (0.55, 0.55) NA (NA, NA) NA (NA, NA) 0.58 (0.58, 0.58) 0.56 (0.56, 0.56) 0.55 (0.55, 0.55) 0.55 (0.55, 0.55) NA (NA, NA) 0.64 (0.64, 0.64) NA (NA, NA) 0.52 (0.52, 0.52) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.57 (0.57, 0.57) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.7 (0.7, 0.7) 0.63 (0.63, 0.63) 0.76 (0.76, 0.76) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC4 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
all TC4 rate 0.054 (0.054, 0.054) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0.163 (0.163, 0.163) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0.088 (0.088, 0.088) NA (NA, NA) 0.229 (0.229, 0.229) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC5 count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
all TC5 time 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7)
all TC5 n 2 (1, 2) 4 (3, 4) 0 (0, 1) 6 (4, 8) 2 (0, 3) 8 (6, 10) 0 (0, 0) 2 (2, 2) 1 (1, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 0) 2 (1, 2) 2 (1, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC5 post_p 0.54 (0.53, 0.55) 0.65 (0.63, 0.68) 0.52 (0.52, 0.52) 0.56 (0.53, 0.59) 0.61 (0.61, 0.61) 0.51 (0.51, 0.51) NA (NA, NA) 0.55 (0.53, 0.57) 0.52 (0.51, 0.52) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.54 (0.54, 0.54) NA (NA, NA) NA (NA, NA) 0.54 (0.52, 0.55) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.52 (0.52, 0.52) 0.52 (0.52, 0.52) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC5 rate 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.015 (0.003, 0.027) 0 (0, 0) 0.063 (0.039, 0.086) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0.38 (0.26, 0.501) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
AR- & TP53- TC1 count 357 357 357 357 357 357 357 357
AR- & TP53- TC1 time 9 (6, 24) 9 (6, 24) 9 (6, 24) 9 (6, 24) 9 (6, 24) 9 (6, 24) 9 (6, 24) 9 (6, 24)
AR- & TP53- TC1 n 27 (19, 85) 4 (2, 15) 1 (0, 3) 2 (0, 6) 2 (0, 11) 0 (0, 0) 1 (0, 4) 0 (0, 2)
AR- & TP53- TC1 post_p 0.86 (0.74, 1) 0.61 (0.52, 0.9) 0.54 (0.51, 0.68) 0.57 (0.51, 0.85) 0.58 (0.52, 0.89) NA (NA, NA) 0.57 (0.51, 0.84) 0.56 (0.51, 0.71)
AR- & TP53- TC1 r_prob 0.41 (0.41, 0.41) 0.22 (0.22, 0.22) 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC1 rate 0.037 (0.015, 0.055) 0.017 (0, 0.079) 0 (0, 0.11) 0 (0, 0.081) 0 (0, 0.066) 0.299 (0.299, 0.299) 0 (0, 0.089) 0 (0, 0.09)
AR- & TP53- TC2 count 3 3 3 3 3 3 3 3
AR- & TP53- TC2 time 10 (9, 14) 10 (9, 14) 10 (9, 14) 10 (9, 14) 10 (9, 14) 10 (9, 14) 10 (9, 14) 10 (9, 14)
AR- & TP53- TC2 n 20 (18, 30) 3 (1, 4) 1 (0, 1) 2 (1, 3) 3 (1, 3) 0 (0, 0) 1 (0, 2) 0 (0, 1)
AR- & TP53- TC2 post_p 0.85 (0.79, 0.92) 0.55 (0.53, 0.6) NA (NA, NA) 0.62 (0.59, 0.67) 0.52 (0.51, 0.52) NA (NA, NA) 0.57 (0.55, 0.58) NA (NA, NA)
AR- & TP53- TC2 r_prob 0.18 (0.18, 0.18) 0.03 (0.03, 0.03) 0.25 (0.25, 0.25) 0.03 (0.03, 0.03) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC2 rate 0.055 (0.033, 0.063) 0.055 (0.011, 0.076) 0.546 (0.109, 0.983) 0 (0, 0) 0.131 (0.122, 0.14) NA (NA, NA) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC3 count 2 2 2 2 2 2 2 2
AR- & TP53- TC3 time 10 (10, 11) 10 (10, 11) 10 (10, 11) 10 (10, 11) 10 (10, 11) 10 (10, 11) 10 (10, 11) 10 (10, 11)
AR- & TP53- TC3 n 26 (23, 29) 4 (4, 5) 0 (0, 0) 0 (0, 1) 6 (1, 11) 0 (0, 0) 3 (2, 4) 0 (0, 1)
AR- & TP53- TC3 post_p 0.84 (0.82, 0.85) 0.69 (0.68, 0.7) NA (NA, NA) 0.52 (0.52, 0.52) 0.78 (0.78, 0.78) NA (NA, NA) 0.56 (0.54, 0.58) 0.54 (0.54, 0.54)
AR- & TP53- TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
AR- & TP53- TC3 rate 0.049 (0.044, 0.054) 0.029 (0.006, 0.051) NA (NA, NA) 0 (0, 0) 0.049 (0.049, 0.049) NA (NA, NA) 0.028 (0.006, 0.05) 0 (0, 0)
AR- & TP53- TC4 count 3 3 3 3 3 3 3 3
AR- & TP53- TC4 time 13 (10, 16) 13 (10, 16) 13 (10, 16) 13 (10, 16) 13 (10, 16) 13 (10, 16) 13 (10, 16) 13 (10, 16)
AR- & TP53- TC4 n 13 (9, 26) 8 (3, 9) 1 (0, 3) 5 (3, 5) 3 (3, 5) 0 (0, 0) 4 (3, 6) 1 (1, 3)
AR- & TP53- TC4 post_p 0.75 (0.75, 0.78) 0.77 (0.62, 0.8) 0.57 (0.54, 0.6) 0.59 (0.53, 0.64) 0.5 (0.5, 0.53) NA (NA, NA) 0.61 (0.53, 0.76) 0.52 (0.51, 0.53)
AR- & TP53- TC4 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
AR- & TP53- TC4 rate 0.047 (0.009, 0.066) 0.053 (0.011, 0.057) 0.045 (0.009, 0.081) 0.064 (0.04, 0.104) 0.051 (0.048, 0.097) NA (NA, NA) 0.052 (0.043, 0.073) 0 (0, 0.03)
AR- & TP53- TC5 count 1 1 1 1 1 1 1 1
AR- & TP53- TC5 time 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9)
AR- & TP53- TC5 n 14 (14, 14) 5 (5, 5) 0 (0, 0) 5 (5, 5) 4 (4, 4) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC5 post_p 0.9 (0.9, 0.9) 0.54 (0.54, 0.54) NA (NA, NA) 0.65 (0.65, 0.65) 0.7 (0.7, 0.7) NA (NA, NA) NA (NA, NA) NA (NA, NA)
AR- & TP53- TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC5 rate 0 (0, 0) 0.114 (0.114, 0.114) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC1 count 26 26 26 26 26 26 26 26 26 26 26 26 26 26 26 26
HRD+ TC1 time 24 (20, 34) 24 (20, 34) 24 (20, 34) 24 (20, 34) 24 (20, 34) 24 (20, 34) 24 (20, 34) 24 (20, 34) 24 (20, 34) 24 (20, 34) 24 (20, 34) 24 (20, 34) 24 (20, 34) 24 (20, 34) 24 (20, 34) 24 (20, 34)
HRD+ TC1 n 13 (9, 16) 0 (0, 0) 5 (2, 9) 2 (0, 4) 0 (0, 0) 0 (0, 2) 0 (0, 0) 1 (0, 4) 3 (1, 5) 0 (0, 0) 0 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC1 post_p 0.92 (0.74, 0.97) NA (NA, NA) 0.78 (0.54, 0.94) 0.6 (0.56, 0.78) NA (NA, NA) 0.56 (0.5, 0.74) NA (NA, NA) 0.56 (0.51, 0.84) 0.6 (0.51, 0.85) NA (NA, NA) 0.58 (0.54, 0.67) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC1 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC1 rate 0.036 (0.019, 0.062) NA (NA, NA) 0.034 (0.004, 0.078) 0 (0, 0.095) 0 (0, 0) 0.093 (0, 0.19) 0 (0, 0) 0.022 (0, 0.122) 0.066 (0, 0.119) NA (NA, NA) 0.137 (0, 0.211) NA (NA, NA) 0.252 (0.252, 0.252) 3.182 (3.182, 3.182) NA (NA, NA) 0.219 (0.219, 0.219)
HRD+ TC2 count 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
HRD+ TC2 time 23 (18, 27) 23 (18, 27) 23 (18, 27) 23 (18, 27) 23 (18, 27) 23 (18, 27) 23 (18, 27) 23 (18, 27) 23 (18, 27) 23 (18, 27) 23 (18, 27) 23 (18, 27) 23 (18, 27) 23 (18, 27) 23 (18, 27) 23 (18, 27)
HRD+ TC2 n 14 (8, 15) 0 (0, 0) 5 (5, 6) 3 (2, 5) 0 (0, 0) 1 (1, 3) 0 (0, 0) 4 (1, 5) 3 (2, 4) 0 (0, 0) 0 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC2 post_p 0.85 (0.8, 0.88) NA (NA, NA) 0.7 (0.64, 0.74) 0.62 (0.54, 0.75) NA (NA, NA) 0.61 (0.54, 0.69) NA (NA, NA) 0.92 (0.92, 0.92) 0.67 (0.63, 0.71) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC2 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC2 rate 0.038 (0.03, 0.045) NA (NA, NA) 0.055 (0.047, 0.062) 0 (0, 0.033) NA (NA, NA) 0 (0, 0.019) NA (NA, NA) 0.128 (0.053, 0.203) 0.089 (0.018, 0.117) NA (NA, NA) 0.325 (0.325, 0.325) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC3 count 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
HRD+ TC3 time 22 (17, 23) 22 (17, 23) 22 (17, 23) 22 (17, 23) 22 (17, 23) 22 (17, 23) 22 (17, 23) 22 (17, 23) 22 (17, 23) 22 (17, 23) 22 (17, 23) 22 (17, 23) 22 (17, 23) 22 (17, 23) 22 (17, 23) 22 (17, 23)
HRD+ TC3 n 14 (12, 17) 0 (0, 0) 7 (5, 7) 4 (1, 5) 0 (0, 0) 1 (0, 2) 0 (0, 0) 1 (0, 2) 3 (2, 4) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC3 post_p 0.89 (0.83, 0.93) NA (NA, NA) 0.73 (0.58, 0.77) 0.55 (0.53, 0.57) NA (NA, NA) 0.52 (0.5, 0.53) NA (NA, NA) 0.58 (0.58, 0.58) 0.54 (0.51, 0.83) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC3 r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
HRD+ TC3 rate 0.054 (0.035, 0.061) NA (NA, NA) 0.08 (0.016, 0.1) 0.118 (0.091, 0.144) NA (NA, NA) 0.306 (0.192, 0.419) NA (NA, NA) 0.346 (0.166, 0.527) 0.06 (0.033, 0.085) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC4 count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
HRD+ TC4 time 24 (22, 27) 24 (22, 27) 24 (22, 27) 24 (22, 27) 24 (22, 27) 24 (22, 27) 24 (22, 27) 24 (22, 27) 24 (22, 27) 24 (22, 27) 24 (22, 27) 24 (22, 27) 24 (22, 27) 24 (22, 27) 24 (22, 27) 24 (22, 27)
HRD+ TC4 n 13 (11, 15) 0 (0, 0) 7 (5, 9) 6 (4, 8) 0 (0, 0) 2 (1, 4) 0 (0, 0) 1 (0, 2) 2 (0, 4) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC4 post_p 0.82 (0.81, 0.84) NA (NA, NA) 0.75 (0.56, 0.94) 0.75 (0.67, 0.83) NA (NA, NA) 0.67 (0.67, 0.67) NA (NA, NA) 0.54 (0.54, 0.54) 0.63 (0.63, 0.63) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC4 r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
HRD+ TC4 rate 0.058 (0.055, 0.062) NA (NA, NA) 0.054 (0.054, 0.054) 0.085 (0.075, 0.095) NA (NA, NA) 0.021 (0.004, 0.038) NA (NA, NA) 0.086 (0.086, 0.086) 0.104 (0.104, 0.104) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC1 count 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
TP53+ TC1 time 17 (14, 24) 17 (14, 24) 17 (14, 24) 17 (14, 24) 17 (14, 24) 17 (14, 24) 17 (14, 24) 17 (14, 24) 17 (14, 24) 17 (14, 24) 17 (14, 24) 17 (14, 24) 17 (14, 24) 17 (14, 24) 17 (14, 24) 17 (14, 24)
TP53+ TC1 n 16 (6, 21) 4 (2, 9) 2 (2, 7) 3 (2, 9) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 4 (3, 6) 4 (2, 6) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 post_p 0.84 (0.63, 0.85) 0.62 (0.55, 0.71) 0.58 (0.55, 0.82) 0.62 (0.56, 0.69) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.66 (0.66, 0.66) NA (NA, NA) NA (NA, NA) 0.76 (0.64, 0.79) 0.75 (0.61, 0.76) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC1 r_prob 0.31 (0.31, 0.31) 0.13 (0.13, 0.13) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 rate 0.063 (0.061, 0.094) 0.079 (0.061, 0.094) 0.063 (0.013, 0.089) 0.065 (0.013, 0.095) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0.052 (0.01, 0.111) 0.05 (0.01, 0.058) 0.216 (0.216, 0.216) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC2 count 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6
TP53+ TC2 time 12 (11, 16) 12 (11, 16) 12 (11, 16) 12 (11, 16) 12 (11, 16) 12 (11, 16) 12 (11, 16) 12 (11, 16) 12 (11, 16) 12 (11, 16) 12 (11, 16) 12 (11, 16) 12 (11, 16) 12 (11, 16) 12 (11, 16) 12 (11, 16)
TP53+ TC2 n 4 (2, 8) 3 (2, 6) 2 (2, 3) 4 (2, 5) 0 (0, 0) 0 (0, 2) 0 (0, 0) 0 (0, 2) 0 (0, 1) 0 (0, 0) 9 (8, 10) 2 (2, 4) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC2 post_p 0.69 (0.56, 0.82) 0.7 (0.56, 0.79) 0.56 (0.52, 0.59) 0.64 (0.52, 0.74) NA (NA, NA) 0.68 (0.68, 0.68) NA (NA, NA) 0.55 (0.52, 0.59) NA (NA, NA) NA (NA, NA) 0.88 (0.74, 0.94) 0.55 (0.52, 0.68) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC2 r_prob 0.17 (0.17, 0.17) 0.07 (0.07, 0.07) 0.41 (0.41, 0.41) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC2 rate 0.055 (0.043, 0.098) 0 (0, 0.065) 0.045 (0, 0.333) 0.051 (0.017, 0.154) NA (NA, NA) 0.091 (0.018, 0.228) NA (NA, NA) 0 (0, 0) 0.066 (0.066, 0.066) NA (NA, NA) 0.06 (0.046, 0.07) 0.033 (0, 0.083) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.139 (0.139, 0.139)
TP53+ TC3 count 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5
TP53+ TC3 time 15 (11, 18) 15 (11, 18) 15 (11, 18) 15 (11, 18) 15 (11, 18) 15 (11, 18) 15 (11, 18) 15 (11, 18) 15 (11, 18) 15 (11, 18) 15 (11, 18) 15 (11, 18) 15 (11, 18) 15 (11, 18) 15 (11, 18) 15 (11, 18)
TP53+ TC3 n 5 (3, 8) 5 (4, 7) 1 (0, 3) 6 (4, 7) 0 (0, 0) 2 (0, 2) 0 (0, 0) 1 (0, 2) 0 (0, 0) 0 (0, 0) 4 (2, 4) 3 (2, 4) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC3 post_p 0.7 (0.58, 0.72) 0.7 (0.54, 0.7) 0.57 (0.54, 0.72) 0.73 (0.67, 0.78) NA (NA, NA) 0.54 (0.54, 0.54) NA (NA, NA) 0.54 (0.53, 0.55) NA (NA, NA) NA (NA, NA) 0.74 (0.56, 0.82) 0.61 (0.51, 0.79) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC3 r_prob 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TP53+ TC3 rate 0.052 (0.02, 0.106) 0.109 (0.079, 0.121) 0 (0, 0) 0.031 (0, 0.085) NA (NA, NA) 0.109 (0.089, 0.171) NA (NA, NA) 0 (0, 0.4) NA (NA, NA) NA (NA, NA) 0.072 (0.018, 0.088) 0.063 (0.056, 0.138) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC4 count 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
TP53+ TC4 time 17 (15, 22) 17 (15, 22) 17 (15, 22) 17 (15, 22) 17 (15, 22) 17 (15, 22) 17 (15, 22) 17 (15, 22) 17 (15, 22) 17 (15, 22) 17 (15, 22) 17 (15, 22) 17 (15, 22) 17 (15, 22) 17 (15, 22) 17 (15, 22)
TP53+ TC4 n 4 (3, 6) 5 (4, 10) 2 (0, 4) 4 (4, 11) 0 (0, 0) 2 (1, 4) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 0) 7 (5, 9) 4 (3, 6) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC4 post_p 0.64 (0.59, 0.81) 0.78 (0.7, 0.8) 0.55 (0.54, 0.56) 0.85 (0.75, 0.89) NA (NA, NA) 0.56 (0.52, 0.6) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.72 (0.58, 0.73) 0.55 (0.54, 0.75) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC4 r_prob 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TP53+ TC4 rate 0.068 (0.028, 0.086) 0.042 (0.033, 0.053) 0.097 (0.083, 0.111) 0.03 (0.006, 0.073) NA (NA, NA) 0.15 (0.03, 0.449) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0.077 (0.064, 0.082) 0.09 (0.072, 0.164) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC5 count 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6
TP53+ TC5 time 14 (11, 25) 14 (11, 25) 14 (11, 25) 14 (11, 25) 14 (11, 25) 14 (11, 25) 14 (11, 25) 14 (11, 25) 14 (11, 25) 14 (11, 25) 14 (11, 25) 14 (11, 25) 14 (11, 25) 14 (11, 25) 14 (11, 25) 14 (11, 25)
TP53+ TC5 n 6 (4, 10) 10 (5, 12) 2 (0, 3) 4 (4, 8) 0 (0, 0) 0 (0, 3) 0 (0, 0) 1 (0, 2) 0 (0, 0) 0 (0, 0) 3 (2, 8) 5 (4, 13) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC5 post_p 0.78 (0.59, 0.87) 0.74 (0.59, 0.78) 0.59 (0.55, 0.61) 0.56 (0.52, 0.64) NA (NA, NA) 0.58 (0.58, 0.58) NA (NA, NA) 0.59 (0.59, 0.59) NA (NA, NA) NA (NA, NA) 0.57 (0.52, 0.74) 0.64 (0.59, 0.79) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC5 r_prob 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC5 rate 0.047 (0, 0.168) 0.086 (0.04, 0.118) 0 (0, 0.084) 0.091 (0.067, 0.191) NA (NA, NA) 0 (0, 0.124) NA (NA, NA) 0.062 (0.012, 0.528) NA (NA, NA) NA (NA, NA) 0.07 (0.023, 0.117) 0.064 (0.049, 0.147) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC1 count 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5
TEfus+ TC1 time 21 (17, 29) 21 (17, 29) 21 (17, 29) 21 (17, 29) 21 (17, 29) 21 (17, 29) 21 (17, 29) 21 (17, 29) 21 (17, 29) 21 (17, 29) 21 (17, 29) 21 (17, 29) 21 (17, 29) 21 (17, 29) 21 (17, 29) 21 (17, 29)
TEfus+ TC1 n 1 (0, 2) 4 (2, 5) 3 (1, 4) 8 (4, 9) 0 (0, 2) 0 (0, 2) 0 (0, 0) 2 (1, 3) 3 (3, 5) 2 (0, 2) 7 (4, 13) 3 (3, 6) 1 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 post_p 0.68 (0.6, 0.78) 0.71 (0.63, 0.85) 0.53 (0.52, 0.63) 0.72 (0.55, 0.73) 0.63 (0.53, 0.73) 0.62 (0.56, 0.68) NA (NA, NA) 0.64 (0.54, 0.75) 0.62 (0.52, 0.86) 0.55 (0.52, 0.58) 0.78 (0.68, 0.83) 0.65 (0.53, 0.79) 0.52 (0.52, 0.52) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC1 r_prob 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 rate 0 (0, 0.02) 0.029 (0.004, 0.058) 0.118 (0, 0.513) 0.064 (0.055, 0.072) 0.055 (0.011, 0.1) 0.031 (0.024, 0.037) NA (NA, NA) 0.104 (0.054, 0.458) 0.058 (0.033, 0.238) 0.094 (0.078, 0.166) 0.074 (0.052, 0.123) 0.06 (0.052, 0.153) 0.094 (0.019, 0.179) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC2 count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
TEfus+ TC2 time 12 (11, 13) 12 (11, 13) 12 (11, 13) 12 (11, 13) 12 (11, 13) 12 (11, 13) 12 (11, 13) 12 (11, 13) 12 (11, 13) 12 (11, 13) 12 (11, 13) 12 (11, 13) 12 (11, 13) 12 (11, 13) 12 (11, 13) 12 (11, 13)
TEfus+ TC2 n 0 (0, 1) 2 (1, 2) 4 (3, 5) 6 (4, 7) 2 (1, 2) 0 (0, 0) 0 (0, 0) 2 (0, 4) 2 (1, 3) 3 (3, 3) 6 (4, 8) 4 (3, 4) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 post_p 0.55 (0.55, 0.55) 0.54 (0.54, 0.54) 0.6 (0.57, 0.64) 0.75 (0.74, 0.75) 0.55 (0.53, 0.56) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.55 (0.53, 0.58) 0.57 (0.52, 0.62) 0.76 (0.6, 0.91) 0.58 (0.53, 0.64) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC2 r_prob 0.25 (0.25, 0.25) 0.03 (0.03, 0.03) 0.41 (0.41, 0.41) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.29 (0.29, 0.29) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 rate 0 (0, 0) 0 (0, 0) 0.056 (0.011, 0.101) 0.053 (0.049, 0.057) 0.057 (0.011, 0.102) NA (NA, NA) NA (NA, NA) 0.074 (0.074, 0.074) 0.038 (0.008, 0.069) 0.077 (0.048, 0.105) 0.021 (0.004, 0.038) 0.061 (0.055, 0.067) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC3 count 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
TEfus+ TC3 time 16 (14, 17) 16 (14, 17) 16 (14, 17) 16 (14, 17) 16 (14, 17) 16 (14, 17) 16 (14, 17) 16 (14, 17) 16 (14, 17) 16 (14, 17) 16 (14, 17) 16 (14, 17) 16 (14, 17) 16 (14, 17) 16 (14, 17) 16 (14, 17)
TEfus+ TC3 n 2 (1, 3) 4 (3, 5) 0 (0, 1) 4 (4, 5) 4 (4, 5) 2 (1, 3) 0 (0, 1) 0 (0, 1) 2 (1, 4) 0 (0, 2) 5 (4, 6) 3 (2, 4) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC3 post_p 0.53 (0.51, 0.62) 0.59 (0.55, 0.7) 0.53 (0.53, 0.53) 0.66 (0.6, 0.74) 0.64 (0.53, 0.71) 0.55 (0.52, 0.59) NA (NA, NA) NA (NA, NA) 0.59 (0.53, 0.61) 0.53 (0.51, 0.54) 0.62 (0.52, 0.78) 0.6 (0.58, 0.65) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TEfus+ TC3 rate 0.072 (0, 0.167) 0.055 (0.031, 0.085) 0 (0, 0) 0.066 (0.017, 0.094) 0.068 (0.018, 0.088) 0 (0, 0.082) 0.15 (0.15, 0.15) 0 (0, 0) 0.068 (0, 0.186) 0.1 (0.02, 0.18) 0.101 (0.064, 0.126) 0.104 (0.086, 0.139) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC4 count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
TEfus+ TC4 time 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16)
TEfus+ TC4 n 0 (0, 0) 2 (2, 2) 3 (3, 3) 7 (7, 7) 7 (7, 7) 0 (0, 0) 0 (0, 0) 1 (1, 1) 0 (0, 0) 0 (0, 0) 8 (8, 8) 2 (2, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC4 post_p NA (NA, NA) 0.5 (0.5, 0.5) 0.57 (0.57, 0.57) 0.74 (0.74, 0.74) 0.93 (0.93, 0.93) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.92 (0.92, 0.92) 0.54 (0.54, 0.54) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC4 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TEfus+ TC4 rate NA (NA, NA) 0.205 (0.205, 0.205) 0.148 (0.148, 0.148) 0.084 (0.084, 0.084) 0.028 (0.028, 0.028) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0.048 (0.048, 0.048) 0.119 (0.119, 0.119) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC5 count 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
TEfus+ TC5 time 13 (11, 13) 13 (11, 13) 13 (11, 13) 13 (11, 13) 13 (11, 13) 13 (11, 13) 13 (11, 13) 13 (11, 13) 13 (11, 13) 13 (11, 13) 13 (11, 13) 13 (11, 13) 13 (11, 13) 13 (11, 13) 13 (11, 13) 13 (11, 13)
TEfus+ TC5 n 0 (0, 2) 3 (2, 3) 1 (0, 2) 5 (5, 10) 1 (0, 3) 1 (0, 2) 0 (0, 0) 0 (0, 0) 1 (1, 2) 4 (2, 4) 2 (2, 4) 5 (5, 7) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC5 post_p NA (NA, NA) 0.52 (0.51, 0.55) 0.58 (0.57, 0.6) 0.75 (0.59, 0.79) 0.55 (0.55, 0.56) 0.62 (0.62, 0.62) NA (NA, NA) NA (NA, NA) 0.55 (0.54, 0.56) 0.58 (0.56, 0.6) 0.55 (0.53, 0.65) 0.73 (0.63, 0.8) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC5 rate 0.059 (0.059, 0.059) 0.083 (0.017, 0.106) 0 (0, 0) 0.095 (0.046, 0.101) 0.058 (0.012, 0.105) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0.05 (0.01, 0.084) 0.045 (0.032, 0.094) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC1 count 19 19 19 19 19 19 19 19 19 19 19 19 19 19 19 19
PI3K+ TC1 time 19 (13, 30) 19 (13, 30) 19 (13, 30) 19 (13, 30) 19 (13, 30) 19 (13, 30) 19 (13, 30) 19 (13, 30) 19 (13, 30) 19 (13, 30) 19 (13, 30) 19 (13, 30) 19 (13, 30) 19 (13, 30) 19 (13, 30) 19 (13, 30)
PI3K+ TC1 n 5 (2, 13) 4 (1, 6) 9 (4, 15) 5 (2, 9) 0 (0, 0) 0 (0, 1) 1 (0, 2) 0 (0, 2) 0 (0, 1) 1 (0, 4) 0 (0, 0) 4 (2, 10) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC1 post_p 0.84 (0.7, 0.94) 0.68 (0.54, 0.87) 0.73 (0.59, 0.85) 0.69 (0.53, 0.74) NA (NA, NA) 0.57 (0.54, 0.62) 0.6 (0.54, 0.64) 0.55 (0.54, 0.57) 0.56 (0.53, 0.61) 0.56 (0.53, 0.68) NA (NA, NA) 0.67 (0.53, 0.91) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC1 r_prob 0.22 (0.22, 0.22) 0.22 (0.22, 0.22) 0.13 (0.13, 0.13) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.14 (0.14, 0.14) 0.14 (0.14, 0.14) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC1 rate 0.02 (0, 0.041) 0.045 (0.015, 0.095) 0.07 (0.053, 0.098) 0.081 (0.044, 0.12) NA (NA, NA) 0 (0, 0.058) 0 (0, 0.15) 0.059 (0, 0.558) 0 (0, 0.04) 0.061 (0, 0.195) 0 (0, 0) 0.06 (0, 0.121) NA (NA, NA) NA (NA, NA) 0.887 (0.285, 1.489) NA (NA, NA)
PI3K+ TC2 count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
PI3K+ TC2 time 14 (12, 16) 14 (12, 16) 14 (12, 16) 14 (12, 16) 14 (12, 16) 14 (12, 16) 14 (12, 16) 14 (12, 16) 14 (12, 16) 14 (12, 16) 14 (12, 16) 14 (12, 16) 14 (12, 16) 14 (12, 16) 14 (12, 16) 14 (12, 16)
PI3K+ TC2 n 6 (4, 7) 2 (0, 4) 5 (5, 5) 9 (9, 9) 0 (0, 0) 2 (2, 2) 0 (0, 1) 0 (0, 0) 1 (1, 1) 1 (1, 1) 0 (0, 0) 4 (3, 4) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC2 post_p 0.62 (0.54, 0.69) 0.84 (0.84, 0.84) 0.53 (0.52, 0.54) 0.86 (0.82, 0.9) NA (NA, NA) 0.52 (0.52, 0.52) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.55 (0.52, 0.57) NA (NA, NA) 0.62 (0.57, 0.67) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC2 r_prob 0.03 (0.03, 0.03) 0.03 (0.03, 0.03) 0.07 (0.07, 0.07) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0.21 (0.21, 0.21) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC2 rate 0.089 (0.061, 0.118) 0 (0, 0) 0.136 (0.118, 0.153) 0.017 (0.016, 0.018) NA (NA, NA) 0.157 (0.031, 0.283) 0 (0, 0) NA (NA, NA) 1.234 (0.247, 2.222) 0 (0, 0) NA (NA, NA) 0.038 (0.008, 0.068) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC3 count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
PI3K+ TC3 time 16 (14, 18) 16 (14, 18) 16 (14, 18) 16 (14, 18) 16 (14, 18) 16 (14, 18) 16 (14, 18) 16 (14, 18) 16 (14, 18) 16 (14, 18) 16 (14, 18) 16 (14, 18) 16 (14, 18) 16 (14, 18) 16 (14, 18) 16 (14, 18)
PI3K+ TC3 n 4 (4, 4) 3 (3, 3) 7 (5, 9) 5 (5, 5) 0 (0, 0) 0 (0, 1) 2 (1, 2) 2 (0, 3) 0 (0, 1) 1 (1, 1) 0 (0, 0) 4 (2, 5) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC3 post_p 0.69 (0.65, 0.72) 0.51 (0.51, 0.52) 0.72 (0.7, 0.73) 0.76 (0.68, 0.84) NA (NA, NA) 0.54 (0.54, 0.54) 0.54 (0.54, 0.54) NA (NA, NA) NA (NA, NA) 0.56 (0.56, 0.56) NA (NA, NA) 0.54 (0.53, 0.55) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC3 rate 0.057 (0.055, 0.058) 0.085 (0.078, 0.093) 0.086 (0.082, 0.09) 0.054 (0.036, 0.072) NA (NA, NA) 0 (0, 0) 0.392 (0.127, 0.658) 0.044 (0.044, 0.044) 0.31 (0.31, 0.31) 0 (0, 0) NA (NA, NA) 0.064 (0.047, 0.081) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC4 count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
PI3K+ TC4 time 20 (20, 20) 20 (20, 20) 20 (20, 20) 20 (20, 20) 20 (20, 20) 20 (20, 20) 20 (20, 20) 20 (20, 20) 20 (20, 20) 20 (20, 20) 20 (20, 20) 20 (20, 20) 20 (20, 20) 20 (20, 20) 20 (20, 20) 20 (20, 20)
PI3K+ TC4 n 5 (5, 5) 5 (5, 5) 4 (4, 4) 4 (4, 4) 0 (0, 0) 1 (1, 1) 0 (0, 0) 1 (1, 1) 0 (0, 0) 3 (3, 3) 0 (0, 0) 5 (5, 5) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC4 post_p 0.57 (0.57, 0.57) 0.83 (0.83, 0.83) 0.54 (0.54, 0.54) 0.88 (0.88, 0.88) NA (NA, NA) 0.59 (0.59, 0.59) NA (NA, NA) 0.65 (0.65, 0.65) NA (NA, NA) 0.9 (0.9, 0.9) NA (NA, NA) 0.73 (0.73, 0.73) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC4 r_prob 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC4 rate 0.069 (0.069, 0.069) 0.027 (0.027, 0.027) 0.066 (0.066, 0.066) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0.061 (0.061, 0.061) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0.041 (0.041, 0.041) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
Futility:
signature treatment var —– —-+ —+- —++ –+– –+-+ –++- –+++ -+— -+–+ -+-+- -+-++ -++– -++-+ -+++- -++++ +—- +—+ +–+- +–++ +-+– +-+-+ +-++- +-+++ ++— ++–+ ++-+- ++-++ +++– +++-+ ++++- +++++
all TC1 count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
all TC1 time 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5)
all TC1 n 15 (15, 15) 3 (3, 3) 0 (0, 0) 1 (1, 1) 6 (6, 6) 3 (3, 3) 0 (0, 0) 0 (0, 0) 1 (1, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 1 (1, 1) 0 (0, 0) 0 (0, 0) 1 (1, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 post_p 0.43 (0.43, 0.43) 0.48 (0.48, 0.48) NA (NA, NA) NA (NA, NA) 0.41 (0.41, 0.41) 0.39 (0.39, 0.39) NA (NA, NA) NA (NA, NA) 0.46 (0.46, 0.46) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.5 (0.5, 0.5) NA (NA, NA) NA (NA, NA) 0.46 (0.46, 0.46) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC1 r_prob 0.41 (0.41, 0.41) 0.22 (0.22, 0.22) 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0.31 (0.31, 0.31) 0.13 (0.13, 0.13) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 rate 0.144 (0.144, 0.144) 0.08 (0.08, 0.08) NA (NA, NA) 0 (0, 0) 0.11 (0.11, 0.11) 0.313 (0.313, 0.313) NA (NA, NA) NA (NA, NA) 1.763 (1.763, 1.763) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0.633 (0.633, 0.633) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC2 count 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7
all TC2 time 10 (5, 31) 10 (5, 31) 10 (5, 31) 10 (5, 31) 10 (5, 31) 10 (5, 31) 10 (5, 31) 10 (5, 31) 10 (5, 31) 10 (5, 31) 10 (5, 31) 10 (5, 31) 10 (5, 31) 10 (5, 31) 10 (5, 31) 10 (5, 31) 10 (5, 31) 10 (5, 31) 10 (5, 31) 10 (5, 31) 10 (5, 31) 10 (5, 31) 10 (5, 31) 10 (5, 31) 10 (5, 31) 10 (5, 31) 10 (5, 31) 10 (5, 31) 10 (5, 31) 10 (5, 31) 10 (5, 31) 10 (5, 31)
all TC2 n 9 (8, 24) 3 (1, 6) 0 (0, 1) 1 (0, 6) 3 (2, 8) 3 (0, 4) 1 (1, 4) 4 (2, 7) 2 (0, 6) 0 (0, 0) 1 (0, 2) 0 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1) 2 (1, 3) 0 (0, 1) 2 (1, 4) 1 (0, 3) 0 (0, 1) 0 (0, 0) 6 (2, 12) 3 (1, 6) 1 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC2 post_p 0.38 (0.06, 0.42) 0.38 (0.18, 0.41) 0.48 (0.47, 0.49) 0.4 (0.35, 0.46) 0.42 (0.19, 0.47) 0.4 (0.37, 0.42) 0.42 (0.2, 0.46) 0.28 (0.17, 0.42) 0.38 (0.23, 0.47) NA (NA, NA) 0.3 (0.17, 0.46) 0.36 (0.3, 0.42) NA (NA, NA) 0.44 (0.44, 0.44) NA (NA, NA) NA (NA, NA) 0.48 (0.24, 0.49) 0.45 (0.45, 0.45) 0.48 (0.29, 0.49) 0.47 (0.35, 0.47) 0.43 (0.42, 0.43) NA (NA, NA) 0.33 (0.24, 0.39) 0.38 (0.19, 0.42) 0.4 (0.38, 0.46) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC2 r_prob 0.18 (0.18, 0.18) 0.03 (0.03, 0.03) 0.25 (0.25, 0.25) 0.03 (0.03, 0.03) 0.17 (0.17, 0.17) 0.07 (0.07, 0.07) 0.41 (0.41, 0.41) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0.29 (0.29, 0.29) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC2 rate 0.121 (0.082, 0.144) 0.182 (0.11, 4.167) 0 (0, 0.04) 0.094 (0.083, 0.555) 0.212 (0.075, 0.329) 0.17 (0.15, 0.381) 0.266 (0.076, 3.177) 0.162 (0.138, 0.251) 0.175 (0.118, 2.032) NA (NA, NA) 0.258 (0.132, 0.551) 0.214 (0.17, 0.417) NA (NA, NA) 0.2 (0.2, 0.2) NA (NA, NA) 0.368 (0.148, 0.622) 0.14 (0.097, 0.524) 0.474 (0.189, 0.828) 0.171 (0.052, 0.275) 0.122 (0, 0.337) 0.239 (0.112, 0.28) NA (NA, NA) 0.166 (0.124, 0.717) 0.174 (0.072, 0.586) 0.394 (0.225, 0.559) NA (NA, NA) 0.092 (0.018, 0.166) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC3 count 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
all TC3 time 16 (10, 19) 16 (10, 19) 16 (10, 19) 16 (10, 19) 16 (10, 19) 16 (10, 19) 16 (10, 19) 16 (10, 19) 16 (10, 19) 16 (10, 19) 16 (10, 19) 16 (10, 19) 16 (10, 19) 16 (10, 19) 16 (10, 19) 16 (10, 19) 16 (10, 19) 16 (10, 19) 16 (10, 19) 16 (10, 19) 16 (10, 19) 16 (10, 19) 16 (10, 19) 16 (10, 19) 16 (10, 19) 16 (10, 19) 16 (10, 19) 16 (10, 19) 16 (10, 19) 16 (10, 19) 16 (10, 19) 16 (10, 19)
all TC3 n 15 (8, 15) 5 (2, 8) 0 (0, 0) 1 (0, 3) 5 (3, 7) 3 (3, 6) 2 (0, 4) 1 (0, 5) 2 (1, 4) 0 (0, 0) 4 (2, 6) 0 (0, 2) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 2) 1 (1, 1) 2 (1, 4) 0 (0, 2) 0 (0, 1) 0 (0, 0) 4 (2, 5) 1 (1, 7) 3 (1, 4) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC3 post_p 0.4 (0.24, 0.44) 0.35 (0.29, 0.39) NA (NA, NA) 0.47 (0.45, 0.48) 0.41 (0.34, 0.41) 0.35 (0.33, 0.36) 0.36 (0.33, 0.39) 0.24 (0.17, 0.3) 0.36 (0.26, 0.38) NA (NA, NA) 0.34 (0.22, 0.36) 0.44 (0.44, 0.44) NA (NA, NA) 0.39 (0.39, 0.39) NA (NA, NA) NA (NA, NA) 0.17 (0.17, 0.17) 0.42 (0.41, 0.44) 0.47 (0.4, 0.48) 0.46 (0.46, 0.46) NA (NA, NA) NA (NA, NA) 0.39 (0.24, 0.46) 0.38 (0.38, 0.39) 0.41 (0.19, 0.47) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
all TC3 rate 0.099 (0.086, 0.125) 0.197 (0.111, 0.542) NA (NA, NA) 0.038 (0.008, 0.068) 0.221 (0.14, 0.233) 0.213 (0.16, 0.339) 0.194 (0.122, 0.267) 0.846 (0.295, 1.398) 0.284 (0.27, 3.672) NA (NA, NA) 0.164 (0.129, 0.18) 0.121 (0.121, 0.121) NA (NA, NA) 0.115 (0.115, 0.115) NA (NA, NA) NA (NA, NA) 0.511 (0.511, 0.511) 0.362 (0.279, 1.603) 0.118 (0.024, 0.323) 0.361 (0.361, 0.361) 0 (0, 0) NA (NA, NA) 0.259 (0.146, 0.362) 0.446 (0.159, 4.557) 0.263 (0.166, 0.696) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC4 count 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5
all TC4 time 19 (8, 24) 19 (8, 24) 19 (8, 24) 19 (8, 24) 19 (8, 24) 19 (8, 24) 19 (8, 24) 19 (8, 24) 19 (8, 24) 19 (8, 24) 19 (8, 24) 19 (8, 24) 19 (8, 24) 19 (8, 24) 19 (8, 24) 19 (8, 24) 19 (8, 24) 19 (8, 24) 19 (8, 24) 19 (8, 24) 19 (8, 24) 19 (8, 24) 19 (8, 24) 19 (8, 24) 19 (8, 24) 19 (8, 24) 19 (8, 24) 19 (8, 24) 19 (8, 24) 19 (8, 24) 19 (8, 24) 19 (8, 24)
all TC4 n 8 (5, 22) 3 (1, 7) 1 (0, 2) 2 (0, 4) 3 (1, 4) 3 (2, 5) 1 (0, 3) 1 (0, 4) 6 (4, 6) 0 (0, 0) 4 (1, 6) 0 (0, 1) 0 (0, 0) 1 (0, 2) 0 (0, 0) 0 (0, 3) 1 (1, 3) 0 (0, 0) 2 (0, 3) 0 (0, 0) 0 (0, 0) 0 (0, 0) 2 (1, 5) 4 (2, 6) 1 (0, 3) 0 (0, 0) 1 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC4 post_p 0.34 (0.22, 0.45) 0.38 (0.13, 0.47) 0.34 (0.34, 0.34) 0.27 (0.16, 0.34) 0.38 (0.31, 0.47) 0.45 (0.37, 0.46) 0.42 (0.42, 0.42) 0.23 (0.23, 0.4) 0.35 (0.16, 0.44) NA (NA, NA) 0.41 (0.4, 0.43) 0.46 (0.43, 0.48) NA (NA, NA) 0.4 (0.37, 0.45) NA (NA, NA) NA (NA, NA) 0.41 (0.39, 0.43) NA (NA, NA) 0.39 (0.27, 0.47) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.44 (0.3, 0.48) 0.44 (0.32, 0.45) 0.33 (0.25, 0.4) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC4 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
all TC4 rate 0.111 (0.088, 0.16) 0.358 (0.128, 1.568) 0.223 (0.192, 0.308) 0.245 (0.219, 0.364) 0.164 (0.132, 0.294) 0.128 (0.096, 0.194) 0.209 (0.042, 0.626) 0.21 (0.142, 0.319) 0.17 (0.136, 0.216) NA (NA, NA) 0.161 (0.115, 0.581) 0.302 (0.06, 0.543) NA (NA, NA) 0.19 (0.168, 0.795) NA (NA, NA) 0.119 (0.024, 0.213) 0.272 (0.034, 1.072) NA (NA, NA) 0.26 (0.183, 0.646) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.22 (0.133, 0.378) 0.15 (0.115, 0.256) 1.24 (0.449, 1.517) NA (NA, NA) 0.124 (0.027, 0.219) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC5 count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
all TC5 time 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12)
all TC5 n 8 (8, 8) 9 (9, 9) 2 (2, 2) 4 (4, 4) 7 (7, 7) 5 (5, 5) 0 (0, 0) 4 (4, 4) 2 (2, 2) 0 (0, 0) 0 (0, 0) 1 (1, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 2 (2, 2) 1 (1, 1) 0 (0, 0) 0 (0, 0) 1 (1, 1) 5 (5, 5) 1 (1, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC5 post_p 0.22 (0.22, 0.22) 0.14 (0.14, 0.14) 0.5 (0.5, 0.5) 0.3 (0.3, 0.3) 0.46 (0.46, 0.46) 0.34 (0.34, 0.34) NA (NA, NA) 0.28 (0.28, 0.28) 0.43 (0.43, 0.43) NA (NA, NA) NA (NA, NA) 0.44 (0.44, 0.44) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.5 (0.5, 0.5) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.41 (0.41, 0.41) 0.44 (0.44, 0.44) 0.47 (0.47, 0.47) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC5 rate 0.175 (0.175, 0.175) 0.207 (0.207, 0.207) 0.173 (0.173, 0.173) 0.259 (0.259, 0.259) 0.148 (0.148, 0.148) 0.113 (0.113, 0.113) NA (NA, NA) 0.184 (0.184, 0.184) 0.192 (0.192, 0.192) NA (NA, NA) NA (NA, NA) 0.304 (0.304, 0.304) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0.134 (0.134, 0.134) NA (NA, NA) NA (NA, NA) 0.337 (0.337, 0.337) 0.094 (0.094, 0.094) 0.338 (0.338, 0.338) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
AR- & TP53- TC1 count 1 1 1 1 1 1 1 1
AR- & TP53- TC1 time 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4)
AR- & TP53- TC1 n 24 (24, 24) 2 (2, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC1 post_p 0.38 (0.38, 0.38) 0.4 (0.4, 0.4) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
AR- & TP53- TC1 r_prob 0.41 (0.41, 0.41) 0.22 (0.22, 0.22) 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC1 rate 0.093 (0.093, 0.093) 0.51 (0.51, 0.51) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
AR- & TP53- TC2 count 235 235 235 235 235 235 235 235
AR- & TP53- TC2 time 23 (13, 34) 23 (13, 34) 23 (13, 34) 23 (13, 34) 23 (13, 34) 23 (13, 34) 23 (13, 34) 23 (13, 34)
AR- & TP53- TC2 n 17 (9, 53) 7 (3, 19) 2 (0, 5) 4 (1, 10) 6 (3, 17) 0 (0, 0) 3 (1, 8) 1 (0, 4)
AR- & TP53- TC2 post_p 0.1 (0.01, 0.39) 0.3 (0.11, 0.46) 0.41 (0.27, 0.49) 0.41 (0.21, 0.48) 0.35 (0.13, 0.48) NA (NA, NA) 0.37 (0.19, 0.48) 0.42 (0.3, 0.48)
AR- & TP53- TC2 r_prob 0.18 (0.18, 0.18) 0.03 (0.03, 0.03) 0.25 (0.25, 0.25) 0.03 (0.03, 0.03) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC2 rate 0.122 (0.093, 0.191) 0.137 (0.09, 0.299) 0.168 (0.066, 0.476) 0.138 (0.08, 0.411) 0.14 (0.091, 0.319) 0.108 (0, 0.721) 0.163 (0.093, 0.451) 0.18 (0.066, 0.622)
AR- & TP53- TC3 count 243 243 243 243 243 243 243 243
AR- & TP53- TC3 time 22 (12, 32) 22 (12, 32) 22 (12, 32) 22 (12, 32) 22 (12, 32) 22 (12, 32) 22 (12, 32) 22 (12, 32)
AR- & TP53- TC3 n 16 (8, 62) 6 (2, 16) 2 (0, 4) 3 (1, 8) 7 (4, 17) 0 (0, 0) 4 (1, 9) 2 (0, 4)
AR- & TP53- TC3 post_p 0.17 (0.03, 0.42) 0.32 (0.12, 0.47) 0.43 (0.29, 0.49) 0.39 (0.21, 0.48) 0.33 (0.13, 0.47) 0.45 (0.45, 0.45) 0.38 (0.22, 0.48) 0.42 (0.32, 0.49)
AR- & TP53- TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
AR- & TP53- TC3 rate 0.118 (0.088, 0.19) 0.137 (0.09, 0.288) 0.173 (0.067, 0.502) 0.161 (0.087, 0.653) 0.129 (0.086, 0.234) 0.374 (0, 2.184) 0.146 (0.084, 0.461) 0.172 (0.07, 0.496)
AR- & TP53- TC4 count 218 218 218 218 218 218 218 218
AR- & TP53- TC4 time 22 (13, 34) 22 (13, 34) 22 (13, 34) 22 (13, 34) 22 (13, 34) 22 (13, 34) 22 (13, 34) 22 (13, 34)
AR- & TP53- TC4 n 17 (7, 59) 6 (2, 18) 1 (0, 3) 3 (1, 9) 7 (4, 17) 0 (0, 0) 4 (2, 8) 2 (0, 5)
AR- & TP53- TC4 post_p 0.18 (0.03, 0.46) 0.32 (0.11, 0.46) 0.41 (0.31, 0.48) 0.4 (0.24, 0.49) 0.35 (0.15, 0.47) NA (NA, NA) 0.36 (0.2, 0.47) 0.42 (0.31, 0.49)
AR- & TP53- TC4 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
AR- & TP53- TC4 rate 0.116 (0.087, 0.195) 0.136 (0.089, 0.366) 0.214 (0.055, 0.951) 0.143 (0.081, 0.429) 0.125 (0.086, 0.238) 0.44 (0, 4.478) 0.151 (0.084, 0.464) 0.153 (0.078, 0.599)
AR- & TP53- TC5 count 241 241 241 241 241 241 241 241
AR- & TP53- TC5 time 21 (12, 31) 21 (12, 31) 21 (12, 31) 21 (12, 31) 21 (12, 31) 21 (12, 31) 21 (12, 31) 21 (12, 31)
AR- & TP53- TC5 n 16 (7, 55) 8 (5, 18) 1 (0, 4) 4 (2, 8) 6 (2, 15) 0 (0, 0) 3 (1, 7) 1 (0, 4)
AR- & TP53- TC5 post_p 0.19 (0.03, 0.43) 0.29 (0.1, 0.46) 0.43 (0.28, 0.49) 0.35 (0.17, 0.47) 0.36 (0.15, 0.48) NA (NA, NA) 0.41 (0.21, 0.49) 0.43 (0.33, 0.49)
AR- & TP53- TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC5 rate 0.118 (0.087, 0.2) 0.121 (0.087, 0.221) 0.161 (0.034, 0.537) 0.144 (0.084, 0.387) 0.132 (0.09, 0.352) 0.066 (0, 0.19) 0.162 (0.089, 0.581) 0.154 (0.051, 0.667)
HRD+ TC2 count 47 47 47 47 47 47 47 47 47 47 47 47 47 47 47 47
HRD+ TC2 time 32 (23, 35) 32 (23, 35) 32 (23, 35) 32 (23, 35) 32 (23, 35) 32 (23, 35) 32 (23, 35) 32 (23, 35) 32 (23, 35) 32 (23, 35) 32 (23, 35) 32 (23, 35) 32 (23, 35) 32 (23, 35) 32 (23, 35) 32 (23, 35)
HRD+ TC2 n 14 (7, 22) 0 (0, 0) 6 (2, 13) 3 (1, 6) 0 (0, 0) 1 (0, 3) 0 (0, 0) 1 (0, 3) 3 (1, 5) 0 (0, 0) 1 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC2 post_p 0.29 (0.12, 0.46) NA (NA, NA) 0.39 (0.14, 0.47) 0.42 (0.26, 0.48) NA (NA, NA) 0.39 (0.32, 0.47) NA (NA, NA) 0.43 (0.28, 0.48) 0.38 (0.23, 0.49) NA (NA, NA) 0.42 (0.4, 0.48) NA (NA, NA) 0.46 (0.46, 0.46) NA (NA, NA) 0.46 (0.46, 0.46) NA (NA, NA)
HRD+ TC2 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC2 rate 0.114 (0.097, 0.186) NA (NA, NA) 0.132 (0.09, 0.333) 0.179 (0.086, 0.503) 0.025 (0.005, 0.045) 0.264 (0.088, 0.815) NA (NA, NA) 0.194 (0.072, 0.74) 0.19 (0.101, 0.444) NA (NA, NA) 0.157 (0, 0.706) NA (NA, NA) 0.355 (0.182, 0.93) NA (NA, NA) 0.301 (0.198, 0.405) 0 (0, 0)
HRD+ TC3 count 66 66 66 66 66 66 66 66 66 66 66 66 66 66 66 66
HRD+ TC3 time 27 (20, 34) 27 (20, 34) 27 (20, 34) 27 (20, 34) 27 (20, 34) 27 (20, 34) 27 (20, 34) 27 (20, 34) 27 (20, 34) 27 (20, 34) 27 (20, 34) 27 (20, 34) 27 (20, 34) 27 (20, 34) 27 (20, 34) 27 (20, 34)
HRD+ TC3 n 11 (6, 22) 0 (0, 0) 5 (3, 10) 2 (0, 5) 0 (0, 0) 1 (0, 3) 0 (0, 0) 1 (0, 3) 4 (2, 7) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC3 post_p 0.36 (0.14, 0.47) 0.5 (0.5, 0.5) 0.34 (0.13, 0.47) 0.4 (0.28, 0.48) 0.5 (0.5, 0.5) 0.45 (0.38, 0.49) NA (NA, NA) 0.43 (0.31, 0.48) 0.38 (0.21, 0.48) NA (NA, NA) 0.46 (0.43, 0.48) NA (NA, NA) 0.48 (0.43, 0.49) 0.48 (0.48, 0.48) 0.46 (0.46, 0.46) NA (NA, NA)
HRD+ TC3 r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
HRD+ TC3 rate 0.113 (0.088, 0.168) 0.262 (0.068, 0.491) 0.135 (0.09, 0.353) 0.173 (0.092, 0.441) 0.441 (0.149, 0.732) 0.168 (0.081, 0.566) 0.104 (0.021, 3.235) 0.184 (0.076, 0.416) 0.157 (0.103, 0.411) 0.143 (0.072, 0.215) 0.107 (0.006, 2.756) 0.077 (0.015, 0.233) 0.212 (0, 1.51) 0.36 (0.035, 1.603) 2.084 (0.642, 3.527) 0.266 (0.184, 0.348)
HRD+ TC4 count 55 55 55 55 55 55 55 55 55 55 55 55 55 55 55 55
HRD+ TC4 time 28 (21, 34) 28 (21, 34) 28 (21, 34) 28 (21, 34) 28 (21, 34) 28 (21, 34) 28 (21, 34) 28 (21, 34) 28 (21, 34) 28 (21, 34) 28 (21, 34) 28 (21, 34) 28 (21, 34) 28 (21, 34) 28 (21, 34) 28 (21, 34)
HRD+ TC4 n 13 (6, 22) 0 (0, 0) 4 (2, 10) 3 (1, 5) 0 (0, 0) 2 (0, 4) 0 (0, 0) 2 (0, 4) 3 (1, 7) 0 (0, 0) 0 (0, 2) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC4 post_p 0.3 (0.09, 0.46) 0.48 (0.48, 0.48) 0.33 (0.2, 0.49) 0.41 (0.28, 0.49) NA (NA, NA) 0.42 (0.26, 0.46) NA (NA, NA) 0.44 (0.35, 0.48) 0.37 (0.21, 0.47) NA (NA, NA) 0.44 (0.34, 0.47) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC4 r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
HRD+ TC4 rate 0.118 (0.086, 0.181) 0.122 (0.024, 0.26) 0.143 (0.089, 0.293) 0.173 (0.078, 0.364) 0.192 (0.173, 0.211) 0.195 (0.073, 0.568) 0 (0, 0) 0.184 (0.096, 0.385) 0.156 (0.101, 0.498) 0.121 (0.086, 0.156) 0.165 (0.027, 0.753) NA (NA, NA) 0.111 (0, 0.774) 0.245 (0.236, 0.255) NA (NA, NA) NA (NA, NA)
HRD+ TC5 count 29 29 29 29 29 29 29 29 29 29 29 29 29 29 29 29
HRD+ TC5 time 30 (23, 36) 30 (23, 36) 30 (23, 36) 30 (23, 36) 30 (23, 36) 30 (23, 36) 30 (23, 36) 30 (23, 36) 30 (23, 36) 30 (23, 36) 30 (23, 36) 30 (23, 36) 30 (23, 36) 30 (23, 36) 30 (23, 36) 30 (23, 36)
HRD+ TC5 n 14 (10, 25) 0 (0, 0) 5 (2, 11) 2 (0, 5) 0 (0, 0) 1 (0, 3) 0 (0, 0) 1 (0, 3) 3 (1, 5) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC5 post_p 0.37 (0.12, 0.46) NA (NA, NA) 0.37 (0.24, 0.48) 0.4 (0.32, 0.48) 0.44 (0.44, 0.44) 0.43 (0.29, 0.49) NA (NA, NA) 0.41 (0.34, 0.49) 0.42 (0.28, 0.48) NA (NA, NA) 0.48 (0.45, 0.49) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC5 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC5 rate 0.111 (0.079, 0.141) 0.131 (0.026, 0.22) 0.133 (0.096, 0.292) 0.19 (0.09, 0.467) 0.253 (0.15, 0.355) 0.326 (0.088, 1.119) 0.61 (0.61, 0.61) 0.175 (0.096, 0.689) 0.176 (0.1, 0.554) 0.047 (0.047, 0.047) 0.176 (0.093, 0.9) 0.222 (0.141, 0.303) 0 (0, 0.065) 0.051 (0.051, 0.051) 0.342 (0.342, 0.342) 0.458 (0.458, 0.458)
TP53+ TC1 count 34 34 34 34 34 34 34 34 34 34 34 34 34 34 34 34
TP53+ TC1 time 18 (12, 29) 18 (12, 29) 18 (12, 29) 18 (12, 29) 18 (12, 29) 18 (12, 29) 18 (12, 29) 18 (12, 29) 18 (12, 29) 18 (12, 29) 18 (12, 29) 18 (12, 29) 18 (12, 29) 18 (12, 29) 18 (12, 29) 18 (12, 29)
TP53+ TC1 n 6 (3, 10) 6 (3, 14) 2 (0, 5) 4 (2, 8) 0 (0, 0) 0 (0, 2) 0 (0, 0) 1 (0, 3) 0 (0, 2) 0 (0, 0) 4 (2, 8) 3 (1, 7) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 post_p 0.3 (0.2, 0.44) 0.37 (0.22, 0.46) 0.39 (0.29, 0.47) 0.38 (0.21, 0.46) NA (NA, NA) 0.41 (0.33, 0.46) NA (NA, NA) 0.43 (0.38, 0.49) 0.48 (0.47, 0.49) NA (NA, NA) 0.29 (0.11, 0.48) 0.39 (0.2, 0.48) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC1 r_prob 0.31 (0.31, 0.31) 0.13 (0.13, 0.13) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 rate 0.154 (0.104, 0.289) 0.141 (0.11, 0.312) 0.178 (0.113, 0.372) 0.162 (0.101, 0.338) NA (NA, NA) 0.161 (0.013, 0.381) NA (NA, NA) 0.173 (0.055, 0.726) 0.132 (0, 2.457) NA (NA, NA) 0.204 (0.11, 0.629) 0.165 (0.111, 0.647) 0 (0, 0.929) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC2 count 43 43 43 43 43 43 43 43 43 43 43 43 43 43 43 43
TP53+ TC2 time 19 (15, 29) 19 (15, 29) 19 (15, 29) 19 (15, 29) 19 (15, 29) 19 (15, 29) 19 (15, 29) 19 (15, 29) 19 (15, 29) 19 (15, 29) 19 (15, 29) 19 (15, 29) 19 (15, 29) 19 (15, 29) 19 (15, 29) 19 (15, 29)
TP53+ TC2 n 5 (2, 13) 5 (2, 10) 3 (1, 4) 6 (2, 11) 0 (0, 0) 0 (0, 2) 0 (0, 0) 0 (0, 2) 0 (0, 2) 0 (0, 0) 7 (4, 11) 4 (1, 9) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC2 post_p 0.34 (0.18, 0.49) 0.36 (0.22, 0.48) 0.4 (0.24, 0.48) 0.4 (0.24, 0.47) NA (NA, NA) 0.43 (0.28, 0.48) NA (NA, NA) 0.43 (0.37, 0.49) 0.44 (0.4, 0.48) NA (NA, NA) 0.35 (0.18, 0.45) 0.37 (0.21, 0.48) NA (NA, NA) NA (NA, NA) 0.46 (0.46, 0.46) NA (NA, NA)
TP53+ TC2 r_prob 0.17 (0.17, 0.17) 0.07 (0.07, 0.07) 0.41 (0.41, 0.41) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC2 rate 0.168 (0.104, 0.302) 0.158 (0.116, 0.499) 0.182 (0.104, 0.6) 0.152 (0.112, 0.281) NA (NA, NA) 0.206 (0.044, 0.616) 0.107 (0.021, 0.193) 0.203 (0.063, 0.805) 0.182 (0, 0.632) 0 (0, 0) 0.16 (0.098, 0.267) 0.178 (0.092, 0.49) 0.317 (0.051, 0.647) NA (NA, NA) 0.538 (0.452, 0.623) NA (NA, NA)
TP53+ TC3 count 26 26 26 26 26 26 26 26 26 26 26 26 26 26 26 26
TP53+ TC3 time 24 (19, 31) 24 (19, 31) 24 (19, 31) 24 (19, 31) 24 (19, 31) 24 (19, 31) 24 (19, 31) 24 (19, 31) 24 (19, 31) 24 (19, 31) 24 (19, 31) 24 (19, 31) 24 (19, 31) 24 (19, 31) 24 (19, 31) 24 (19, 31)
TP53+ TC3 n 5 (2, 8) 5 (3, 12) 2 (0, 6) 5 (2, 10) 0 (0, 0) 1 (0, 2) 0 (0, 0) 1 (0, 2) 0 (0, 1) 0 (0, 0) 5 (1, 13) 4 (2, 10) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC3 post_p 0.35 (0.13, 0.48) 0.34 (0.16, 0.47) 0.42 (0.35, 0.47) 0.35 (0.17, 0.46) NA (NA, NA) 0.44 (0.36, 0.5) NA (NA, NA) 0.45 (0.31, 0.49) 0.47 (0.45, 0.49) NA (NA, NA) 0.32 (0.18, 0.48) 0.35 (0.21, 0.44) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC3 r_prob 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TP53+ TC3 rate 0.176 (0.115, 0.448) 0.159 (0.107, 0.436) 0.181 (0.094, 0.485) 0.178 (0.104, 0.572) 1.329 (0.339, 2.32) 0.224 (0, 3.713) 0.093 (0.093, 0.093) 0.115 (0.072, 0.344) 0.069 (0, 0.731) 1.47 (1.47, 1.47) 0.168 (0.112, 0.394) 0.163 (0.085, 0.353) 0.184 (0.03, 1.337) 172.827 (172.827, 172.827) NA (NA, NA) NA (NA, NA)
TP53+ TC4 count 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24
TP53+ TC4 time 22 (17, 30) 22 (17, 30) 22 (17, 30) 22 (17, 30) 22 (17, 30) 22 (17, 30) 22 (17, 30) 22 (17, 30) 22 (17, 30) 22 (17, 30) 22 (17, 30) 22 (17, 30) 22 (17, 30) 22 (17, 30) 22 (17, 30) 22 (17, 30)
TP53+ TC4 n 8 (3, 12) 6 (2, 15) 2 (0, 4) 3 (2, 6) 0 (0, 0) 1 (0, 3) 0 (0, 0) 1 (0, 3) 0 (0, 1) 0 (0, 0) 4 (1, 8) 4 (2, 6) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC4 post_p 0.36 (0.18, 0.46) 0.38 (0.18, 0.49) 0.37 (0.22, 0.46) 0.31 (0.13, 0.46) NA (NA, NA) 0.42 (0.39, 0.48) NA (NA, NA) 0.44 (0.33, 0.49) 0.43 (0.43, 0.45) NA (NA, NA) 0.36 (0.2, 0.47) 0.32 (0.15, 0.46) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC4 r_prob 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TP53+ TC4 rate 0.143 (0.121, 0.289) 0.16 (0.094, 0.265) 0.211 (0.127, 1.225) 0.232 (0.128, 0.588) NA (NA, NA) 0.23 (0, 0.703) 0.763 (0.763, 0.763) 0.15 (0.1, 1.135) 0.252 (0.076, 0.376) NA (NA, NA) 0.177 (0.115, 0.369) 0.243 (0.134, 0.34) 0.08 (0.016, 0.085) 0.403 (0.403, 0.403) 0.144 (0.144, 0.144) 0.534 (0.534, 0.534)
TP53+ TC5 count 42 42 42 42 42 42 42 42 42 42 42 42 42 42 42 42
TP53+ TC5 time 21 (13, 32) 21 (13, 32) 21 (13, 32) 21 (13, 32) 21 (13, 32) 21 (13, 32) 21 (13, 32) 21 (13, 32) 21 (13, 32) 21 (13, 32) 21 (13, 32) 21 (13, 32) 21 (13, 32) 21 (13, 32) 21 (13, 32) 21 (13, 32)
TP53+ TC5 n 6 (2, 13) 7 (4, 10) 2 (0, 4) 5 (2, 10) 0 (0, 0) 1 (0, 2) 0 (0, 0) 1 (0, 2) 0 (0, 1) 0 (0, 0) 4 (1, 12) 4 (2, 8) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC5 post_p 0.36 (0.21, 0.47) 0.3 (0.16, 0.47) 0.43 (0.27, 0.49) 0.36 (0.16, 0.49) NA (NA, NA) 0.44 (0.35, 0.48) NA (NA, NA) 0.41 (0.36, 0.47) 0.45 (0.36, 0.49) NA (NA, NA) 0.37 (0.18, 0.48) 0.33 (0.18, 0.49) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC5 r_prob 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC5 rate 0.154 (0.108, 0.343) 0.149 (0.102, 0.227) 0.188 (0.109, 0.514) 0.152 (0.088, 0.322) NA (NA, NA) 0.208 (0.064, 0.588) NA (NA, NA) 0.233 (0.037, 1.219) 0.019 (0, 0.766) NA (NA, NA) 0.187 (0.106, 0.567) 0.177 (0.111, 0.488) 0.166 (0.033, 1.866) 0.088 (0.058, 0.117) 0.174 (0.174, 0.174) 0 (0, 0)
TEfus+ TC1 count 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
TEfus+ TC1 time 26 (24, 33) 26 (24, 33) 26 (24, 33) 26 (24, 33) 26 (24, 33) 26 (24, 33) 26 (24, 33) 26 (24, 33) 26 (24, 33) 26 (24, 33) 26 (24, 33) 26 (24, 33) 26 (24, 33) 26 (24, 33) 26 (24, 33) 26 (24, 33)
TEfus+ TC1 n 1 (0, 4) 0 (0, 1) 2 (1, 5) 7 (4, 10) 0 (0, 1) 0 (0, 0) 0 (0, 0) 1 (1, 3) 2 (1, 4) 0 (0, 2) 8 (4, 10) 6 (4, 10) 0 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 post_p 0.44 (0.44, 0.44) 0.46 (0.45, 0.47) 0.37 (0.32, 0.47) 0.4 (0.28, 0.45) 0.47 (0.47, 0.47) NA (NA, NA) NA (NA, NA) 0.46 (0.46, 0.47) 0.46 (0.34, 0.48) 0.38 (0.37, 0.39) 0.23 (0.09, 0.39) 0.4 (0.19, 0.43) 0.45 (0.44, 0.45) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC1 r_prob 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 rate 0.079 (0.071, 0.088) 0.105 (0.103, 0.107) 0.222 (0.124, 0.348) 0.118 (0.097, 0.122) 0.079 (0.079, 0.079) NA (NA, NA) NA (NA, NA) 0.153 (0.044, 0.233) 0.212 (0.12, 0.554) 17.642 (3.788, 31.495) 0.191 (0.121, 0.493) 0.18 (0.144, 0.284) 0.15 (0.03, 0.27) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC2 count 21 21 21 21 21 21 21 21 21 21 21 21 21 21 21 21
TEfus+ TC2 time 22 (15, 33) 22 (15, 33) 22 (15, 33) 22 (15, 33) 22 (15, 33) 22 (15, 33) 22 (15, 33) 22 (15, 33) 22 (15, 33) 22 (15, 33) 22 (15, 33) 22 (15, 33) 22 (15, 33) 22 (15, 33) 22 (15, 33) 22 (15, 33)
TEfus+ TC2 n 2 (0, 3) 3 (1, 7) 2 (1, 4) 5 (3, 11) 2 (0, 5) 1 (0, 2) 0 (0, 0) 0 (0, 2) 4 (1, 6) 1 (0, 2) 5 (2, 13) 5 (2, 10) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 post_p 0.44 (0.25, 0.49) 0.36 (0.24, 0.47) 0.44 (0.25, 0.47) 0.43 (0.18, 0.48) 0.32 (0.14, 0.49) 0.45 (0.33, 0.49) NA (NA, NA) 0.39 (0.32, 0.42) 0.38 (0.21, 0.48) 0.46 (0.31, 0.49) 0.32 (0.19, 0.47) 0.42 (0.23, 0.48) 0.46 (0.46, 0.46) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC2 r_prob 0.25 (0.25, 0.25) 0.03 (0.03, 0.03) 0.41 (0.41, 0.41) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.29 (0.29, 0.29) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 rate 0.115 (0.019, 0.42) 0.173 (0.086, 0.34) 0.189 (0.082, 0.667) 0.155 (0.097, 0.229) 0.184 (0.076, 0.576) 0.191 (0.049, 0.357) NA (NA, NA) 0.215 (0.09, 0.64) 0.164 (0.093, 0.324) 0.24 (0.125, 0.46) 0.166 (0.103, 0.727) 0.16 (0.113, 0.419) 0.13 (0, 0.799) NA (NA, NA) NA (NA, NA) 0 (0, 0)
TEfus+ TC3 count 21 21 21 21 21 21 21 21 21 21 21 21 21 21 21 21
TEfus+ TC3 time 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32)
TEfus+ TC3 n 2 (0, 2) 3 (1, 7) 2 (0, 4) 4 (2, 6) 4 (1, 10) 2 (1, 3) 0 (0, 0) 1 (0, 3) 2 (0, 4) 1 (0, 2) 4 (2, 7) 5 (2, 9) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC3 post_p 0.38 (0.27, 0.47) 0.37 (0.2, 0.45) 0.42 (0.34, 0.48) 0.39 (0.17, 0.47) 0.33 (0.2, 0.42) 0.41 (0.38, 0.47) NA (NA, NA) 0.43 (0.27, 0.47) 0.42 (0.32, 0.48) 0.47 (0.37, 0.49) 0.36 (0.16, 0.49) 0.31 (0.16, 0.43) 0.45 (0.45, 0.45) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TEfus+ TC3 rate 0.172 (0.056, 0.439) 0.146 (0.077, 0.451) 0.142 (0.1, 0.393) 0.152 (0.106, 0.353) 0.165 (0.093, 0.276) 0.186 (0.074, 0.698) 0.411 (0.411, 0.411) 0.153 (0.043, 1.579) 0.167 (0.118, 0.379) 0.181 (0.099, 0.848) 0.162 (0.114, 0.387) 0.176 (0.09, 0.343) 0.151 (0.034, 0.196) 0 (0, 0) 0.281 (0.281, 0.281) NA (NA, NA)
TEfus+ TC4 count 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18
TEfus+ TC4 time 22 (19, 31) 22 (19, 31) 22 (19, 31) 22 (19, 31) 22 (19, 31) 22 (19, 31) 22 (19, 31) 22 (19, 31) 22 (19, 31) 22 (19, 31) 22 (19, 31) 22 (19, 31) 22 (19, 31) 22 (19, 31) 22 (19, 31) 22 (19, 31)
TEfus+ TC4 n 1 (1, 3) 2 (1, 7) 2 (1, 3) 5 (1, 9) 4 (1, 6) 2 (0, 4) 0 (0, 0) 2 (0, 4) 2 (1, 5) 0 (0, 3) 5 (3, 9) 3 (2, 6) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC4 post_p 0.39 (0.34, 0.47) 0.37 (0.26, 0.45) 0.41 (0.24, 0.47) 0.42 (0.35, 0.49) 0.28 (0.19, 0.4) 0.39 (0.32, 0.47) NA (NA, NA) 0.46 (0.34, 0.49) 0.37 (0.2, 0.45) 0.39 (0.32, 0.42) 0.38 (0.2, 0.46) 0.35 (0.22, 0.45) 0.44 (0.4, 0.47) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC4 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TEfus+ TC4 rate 0.316 (0.123, 1.031) 0.189 (0.1, 0.267) 0.23 (0.032, 0.796) 0.145 (0.106, 0.361) 0.207 (0.108, 0.475) 0.172 (0.106, 0.527) NA (NA, NA) 0.208 (0.102, 0.553) 0.281 (0.16, 0.582) 0.189 (0.124, 0.491) 0.165 (0.113, 0.303) 0.224 (0.149, 0.556) 0.12 (0, 0.272) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC5 count 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18
TEfus+ TC5 time 24 (13, 31) 24 (13, 31) 24 (13, 31) 24 (13, 31) 24 (13, 31) 24 (13, 31) 24 (13, 31) 24 (13, 31) 24 (13, 31) 24 (13, 31) 24 (13, 31) 24 (13, 31) 24 (13, 31) 24 (13, 31) 24 (13, 31) 24 (13, 31)
TEfus+ TC5 n 1 (0, 4) 5 (2, 7) 2 (0, 4) 6 (4, 9) 2 (1, 7) 1 (0, 2) 0 (0, 0) 1 (0, 3) 2 (1, 4) 1 (0, 4) 3 (1, 6) 5 (3, 7) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC5 post_p 0.43 (0.31, 0.48) 0.3 (0.19, 0.41) 0.43 (0.27, 0.49) 0.33 (0.15, 0.45) 0.36 (0.2, 0.46) 0.42 (0.34, 0.47) NA (NA, NA) 0.4 (0.39, 0.45) 0.41 (0.34, 0.48) 0.42 (0.31, 0.45) 0.33 (0.16, 0.45) 0.37 (0.23, 0.49) 0.49 (0.49, 0.49) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC5 rate 0.229 (0.086, 1.262) 0.167 (0.114, 0.338) 0.164 (0.065, 0.761) 0.141 (0.084, 0.279) 0.328 (0.131, 1.253) 0.15 (0.091, 0.384) NA (NA, NA) 0.268 (0.099, 1.271) 0.152 (0.106, 0.411) 0.17 (0.095, 0.418) 0.269 (0.133, 0.595) 0.163 (0.105, 0.274) 0.187 (0.03, 0.591) NA (NA, NA) NA (NA, NA) 0 (0, 0)
PI3K+ TC1 count 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
PI3K+ TC1 time 23 (14, 31) 23 (14, 31) 23 (14, 31) 23 (14, 31) 23 (14, 31) 23 (14, 31) 23 (14, 31) 23 (14, 31) 23 (14, 31) 23 (14, 31) 23 (14, 31) 23 (14, 31) 23 (14, 31) 23 (14, 31) 23 (14, 31) 23 (14, 31)
PI3K+ TC1 n 2 (1, 8) 2 (0, 4) 5 (4, 11) 6 (4, 7) 0 (0, 0) 0 (0, 1) 1 (0, 1) 0 (0, 1) 2 (0, 2) 1 (0, 2) 0 (0, 0) 6 (6, 7) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC1 post_p 0.43 (0.41, 0.44) 0.46 (0.44, 0.48) 0.46 (0.23, 0.49) 0.31 (0.3, 0.33) NA (NA, NA) NA (NA, NA) 0.34 (0.32, 0.35) 0.47 (0.47, 0.47) NA (NA, NA) 0.43 (0.42, 0.45) NA (NA, NA) 0.42 (0.38, 0.47) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC1 r_prob 0.22 (0.22, 0.22) 0.22 (0.22, 0.22) 0.13 (0.13, 0.13) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.14 (0.14, 0.14) 0.14 (0.14, 0.14) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC1 rate 0.096 (0.094, 0.219) 0.201 (0.093, 0.31) 0.121 (0.095, 0.21) 0.156 (0.113, 0.246) NA (NA, NA) 0.949 (0.949, 0.949) 0.254 (0.243, 0.265) 0.146 (0.146, 0.146) 0.278 (0.194, 0.362) 0.252 (0.195, 0.31) NA (NA, NA) 0.147 (0.111, 0.154) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC2 count 46 46 46 46 46 46 46 46 46 46 46 46 46 46 46 46
PI3K+ TC2 time 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33)
PI3K+ TC2 n 7 (4, 12) 4 (2, 9) 5 (2, 10) 5 (3, 10) 0 (0, 0) 1 (0, 4) 0 (0, 2) 1 (0, 2) 1 (0, 2) 1 (0, 3) 0 (0, 0) 5 (2, 9) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC2 post_p 0.27 (0.1, 0.44) 0.37 (0.2, 0.48) 0.36 (0.17, 0.47) 0.35 (0.18, 0.48) NA (NA, NA) 0.39 (0.3, 0.49) 0.42 (0.35, 0.49) 0.42 (0.26, 0.47) 0.44 (0.33, 0.49) 0.4 (0.3, 0.49) 0.48 (0.48, 0.48) 0.36 (0.21, 0.49) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC2 r_prob 0.03 (0.03, 0.03) 0.03 (0.03, 0.03) 0.07 (0.07, 0.07) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0.21 (0.21, 0.21) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC2 rate 0.146 (0.095, 0.316) 0.144 (0.088, 0.289) 0.164 (0.104, 0.48) 0.156 (0.106, 0.309) NA (NA, NA) 0.178 (0.093, 0.671) 0.166 (0, 0.393) 0.186 (0.076, 2.725) 0.206 (0, 0.924) 0.192 (0.067, 0.481) 0.104 (0.021, 0.295) 0.147 (0.106, 0.412) NA (NA, NA) NA (NA, NA) 0.162 (0.162, 0.162) 0 (0, 0)
PI3K+ TC3 count 39 39 39 39 39 39 39 39 39 39 39 39 39 39 39 39
PI3K+ TC3 time 25 (17, 31) 25 (17, 31) 25 (17, 31) 25 (17, 31) 25 (17, 31) 25 (17, 31) 25 (17, 31) 25 (17, 31) 25 (17, 31) 25 (17, 31) 25 (17, 31) 25 (17, 31) 25 (17, 31) 25 (17, 31) 25 (17, 31) 25 (17, 31)
PI3K+ TC3 n 5 (2, 11) 3 (1, 8) 6 (3, 10) 4 (2, 9) 0 (0, 0) 2 (0, 3) 1 (0, 2) 2 (0, 4) 0 (0, 2) 1 (0, 3) 0 (0, 0) 4 (2, 9) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0)
PI3K+ TC3 post_p 0.28 (0.12, 0.42) 0.4 (0.26, 0.47) 0.31 (0.19, 0.45) 0.38 (0.22, 0.45) NA (NA, NA) 0.41 (0.31, 0.49) 0.44 (0.37, 0.48) 0.46 (0.34, 0.49) 0.45 (0.4, 0.46) 0.44 (0.37, 0.49) NA (NA, NA) 0.33 (0.19, 0.47) NA (NA, NA) NA (NA, NA) 0.48 (0.48, 0.48) NA (NA, NA)
PI3K+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC3 rate 0.161 (0.105, 0.432) 0.124 (0.076, 0.879) 0.182 (0.114, 0.295) 0.169 (0.122, 0.371) NA (NA, NA) 0.12 (0.064, 0.405) 0.18 (0, 0.471) 0.148 (0.01, 0.464) 0.319 (0, 0.75) 0.178 (0.059, 0.387) 0.091 (0.069, 0.114) 0.191 (0.102, 0.74) NA (NA, NA) 0.13 (0, 1.694) 2.794 (2.794, 2.794) 0.355 (0.355, 0.355)
PI3K+ TC4 count 43 43 43 43 43 43 43 43 43 43 43 43 43 43 43 43
PI3K+ TC4 time 25 (18, 35) 25 (18, 35) 25 (18, 35) 25 (18, 35) 25 (18, 35) 25 (18, 35) 25 (18, 35) 25 (18, 35) 25 (18, 35) 25 (18, 35) 25 (18, 35) 25 (18, 35) 25 (18, 35) 25 (18, 35) 25 (18, 35) 25 (18, 35)
PI3K+ TC4 n 8 (3, 13) 4 (1, 8) 7 (3, 16) 5 (2, 9) 0 (0, 0) 2 (0, 5) 1 (0, 3) 1 (0, 3) 0 (0, 1) 1 (0, 2) 0 (0, 0) 3 (2, 10) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC4 post_p 0.33 (0.13, 0.42) 0.37 (0.23, 0.46) 0.36 (0.15, 0.48) 0.35 (0.21, 0.47) NA (NA, NA) 0.44 (0.33, 0.48) 0.43 (0.25, 0.48) 0.42 (0.33, 0.47) 0.46 (0.37, 0.47) 0.42 (0.25, 0.47) NA (NA, NA) 0.36 (0.15, 0.47) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC4 r_prob 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC4 rate 0.129 (0.087, 0.196) 0.148 (0.086, 0.402) 0.147 (0.107, 0.348) 0.184 (0.105, 0.418) NA (NA, NA) 0.148 (0.083, 0.444) 0.256 (0.059, 0.477) 0.165 (0.068, 0.682) 0.275 (0.04, 1.687) 0.203 (0.041, 1.225) 0.078 (0.016, 0.14) 0.184 (0.097, 0.527) 0.291 (0.291, 0.291) 0.421 (0.421, 0.421) 0.445 (0.295, 0.595) 0.534 (0.534, 0.534)
PI3K+ TC5 count 66 66 66 66 66 66 66 66 66 66 66 66 66 66 66 66
PI3K+ TC5 time 17 (11, 32) 17 (11, 32) 17 (11, 32) 17 (11, 32) 17 (11, 32) 17 (11, 32) 17 (11, 32) 17 (11, 32) 17 (11, 32) 17 (11, 32) 17 (11, 32) 17 (11, 32) 17 (11, 32) 17 (11, 32) 17 (11, 32) 17 (11, 32)
PI3K+ TC5 n 8 (4, 14) 4 (2, 9) 6 (3, 11) 5 (3, 9) 0 (0, 0) 1 (0, 4) 0 (0, 2) 1 (0, 2) 1 (0, 2) 1 (0, 3) 0 (0, 0) 4 (2, 10) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC5 post_p 0.29 (0.1, 0.45) 0.39 (0.17, 0.48) 0.35 (0.16, 0.46) 0.37 (0.2, 0.48) NA (NA, NA) 0.42 (0.35, 0.49) 0.43 (0.32, 0.47) 0.45 (0.36, 0.48) 0.45 (0.32, 0.49) 0.41 (0.32, 0.48) NA (NA, NA) 0.4 (0.21, 0.48) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC5 r_prob 0.38 (0.38, 0.38) 0.38 (0.38, 0.38) 0.33 (0.33, 0.33) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC5 rate 0.137 (0.085, 0.265) 0.147 (0.074, 0.326) 0.163 (0.105, 0.368) 0.151 (0.103, 0.325) 0.065 (0.013, 0.118) 0.178 (0.066, 0.439) 0.28 (0.075, 0.791) 0.164 (0, 0.626) 0.155 (0, 1.583) 0.196 (0.036, 0.669) 0.081 (0, 49.977) 0.156 (0.092, 0.363) 0.451 (0.082, 0.977) NA (NA, NA) 0.179 (0.036, 0.322) 0.196 (0, 1.111)