Simulation scenario 4, CR phase

Setting description

TC1 more effective in the TP53- & AR- biomarker signature

Simulations setting

Survival curves (by signature)

PFS distributions (by signature)

Treatment effects (by signature)

signature	var	Other	TC1	TC2	TC3	TC4	TC5
all	param	scale = 0.112, shape = 1.05	scale = 0.073, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
all	summary	mean = 8.8, median = 6.3	mean = 13.5, median = 9.7	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
all	effect	af = 1, hr = 1	af = 1.54, hr = 0.64	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
AR- & TP53-	param	scale = 0.112, shape = 1.05	scale = 0.042, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
AR- & TP53-	summary	mean = 8.8, median = 6.3	mean = 23.4, median = 16.9	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
AR- & TP53-	effect	af = 1, hr = 1	af = 2.67, hr = 0.36	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
HRD+	param	scale = 0.112, shape = 1.05	scale = 0.063, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
HRD+	summary	mean = 8.8, median = 6.3	mean = 15.6, median = 11.2	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
HRD+	effect	af = 1, hr = 1	af = 1.78, hr = 0.55	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
TP53+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
TP53+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
TP53+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
TEfus+	param	scale = 0.112, shape = 1.05	scale = 0.09, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
TEfus+	summary	mean = 8.8, median = 6.3	mean = 10.9, median = 7.8	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
TEfus+	effect	af = 1, hr = 1	af = 1.23, hr = 0.8	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
PI3K+	param	scale = 0.112, shape = 1.05	scale = 0.085, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
PI3K+	summary	mean = 8.8, median = 6.3	mean = 11.5, median = 8.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
PI3K+	effect	af = 1, hr = 1	af = 1.31, hr = 0.75	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1

Survival curves (by subgroup)

PFS distributions (by subgroup)

Treatment effects (by subgroup)

subtype	var	Other	TC1	TC2	TC3	TC4	TC5
—–	param	scale = 0.112, shape = 1.05	scale = 0.042, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
—–	summary	mean = 8.8, median = 6.3	mean = 23.4, median = 16.9	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
—–	effect	af = 1, hr = 1	af = 2.67, hr = 0.36	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
—-+	param	scale = 0.112, shape = 1.05	scale = 0.042, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
—-+	summary	mean = 8.8, median = 6.3	mean = 23.4, median = 16.9	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
—-+	effect	af = 1, hr = 1	af = 2.67, hr = 0.36	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
—+-	param	scale = 0.112, shape = 1.05	scale = 0.042, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
—+-	summary	mean = 8.8, median = 6.3	mean = 23.4, median = 16.9	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
—+-	effect	af = 1, hr = 1	af = 2.67, hr = 0.36	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
—++	param	scale = 0.112, shape = 1.05	scale = 0.042, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
—++	summary	mean = 8.8, median = 6.3	mean = 23.4, median = 16.9	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
—++	effect	af = 1, hr = 1	af = 2.67, hr = 0.36	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–+–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
–+–	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
–+–	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–+-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
–+-+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
–+-+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
–++-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
–++-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–+++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
–+++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
–+++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+—	param	scale = 0.112, shape = 1.05	scale = 0.042, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
-+—	summary	mean = 8.8, median = 6.3	mean = 23.4, median = 16.9	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
-+—	effect	af = 1, hr = 1	af = 2.67, hr = 0.36	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+–+	param	scale = 0.112, shape = 1.05	scale = 0.042, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
-+–+	summary	mean = 8.8, median = 6.3	mean = 23.4, median = 16.9	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
-+–+	effect	af = 1, hr = 1	af = 2.67, hr = 0.36	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+-+-	param	scale = 0.112, shape = 1.05	scale = 0.042, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
-+-+-	summary	mean = 8.8, median = 6.3	mean = 23.4, median = 16.9	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
-+-+-	effect	af = 1, hr = 1	af = 2.67, hr = 0.36	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+-++	param	scale = 0.112, shape = 1.05	scale = 0.042, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
-+-++	summary	mean = 8.8, median = 6.3	mean = 23.4, median = 16.9	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
-+-++	effect	af = 1, hr = 1	af = 2.67, hr = 0.36	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-++–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
-++–	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
-++–	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-++-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
-++-+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
-++-+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
-+++-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
-+++-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-++++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
-++++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
-++++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+—-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+—-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+—-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+—+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+—+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+—+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+–+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+–+-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+–+-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+–++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+–++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+–++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-+–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+-+–	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+-+–	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-+-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+-+-+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+-+-+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+-++-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+-++-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-+++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+-+++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+-+++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++—	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
++—	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
++—	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++–+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
++–+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
++–+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++-+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
++-+-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
++-+-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++-++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
++-++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
++-++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+++–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+++–	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+++–	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+++-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+++-+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+++-+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
++++-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
++++-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+++++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+++++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+++++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1

Errors and power

graduation (counts and proportions):

TC1 TC2 TC3 TC4 TC5 all 52 4 4 1 2 AR- & TP53- 357 3 2 3 1 HRD+ 26 3 3 2 0 TP53+ 3 6 5 3 6 TEfus+ 5 2 4 1 3 PI3K+ 19 2 2 1 0

TC1 TC2 TC3 TC4 TC5 all 0.104 0.008 0.008 0.002 0.004 AR- & TP53- 0.714 0.006 0.004 0.006 0.002 HRD+ 0.052 0.006 0.006 0.004 0.000 TP53+ 0.006 0.012 0.010 0.006 0.012 TEfus+ 0.010 0.004 0.008 0.002 0.006 PI3K+ 0.038 0.004 0.004 0.002 0.000

futility (counts and proportions):

TC1 TC2 TC3 TC4 TC5 all 1 7 3 5 1 AR- & TP53- 1 235 243 218 241 HRD+ 0 47 66 55 29 TP53+ 34 43 26 24 42 TEfus+ 4 21 21 18 18 PI3K+ 3 46 39 43 66

TC1 TC2 TC3 TC4 TC5 all 0.002 0.014 0.006 0.010 0.002 AR- & TP53- 0.002 0.470 0.486 0.436 0.482 HRD+ 0.000 0.094 0.132 0.110 0.058 TP53+ 0.068 0.086 0.052 0.048 0.084 TEfus+ 0.008 0.042 0.042 0.036 0.036 PI3K+ 0.006 0.092 0.078 0.086 0.132

max sample size (counts and proportions):

TC1 TC2 TC3 TC4 TC5 all 0 0 0 0 0 AR- & TP53- 106 39 60 77 57 HRD+ 0 0 0 0 0 TP53+ 0 0 0 0 0 TEfus+ 0 0 0 0 0 PI3K+ 0 0 0 0 0

TC1 TC2 TC3 TC4 TC5 all 0.000 0.000 0.00 0.000 0.000 AR- & TP53- 0.212 0.078 0.12 0.154 0.114 HRD+ 0.000 0.000 0.00 0.000 0.000 TP53+ 0.000 0.000 0.00 0.000 0.000 TEfus+ 0.000 0.000 0.00 0.000 0.000 PI3K+ 0.000 0.000 0.00 0.000 0.000

Operating characteristics

char	overall	TC1	TC2	TC3	TC4	TC5
err_sign	0.2104208	0.1042084	0.0380762	0.0360721	0.0220441	0.0220441
err_type	0.3046092	0.2084168	0.0380762	0.0360721	0.0220441	0.0220441
pow_sign	0.7154309	0.7154309	0.0000000	0.0000000	0.0000000	0.0000000
pow_type	0.7895792	0.7895792	0.0000000	0.0000000	0.0000000	0.0000000

Median results at the end of the trial

By signature:

signature	var	Control	TC1	TC2	TC3	TC4	TC5
all	graduation	0	52	4	4	1	2
all	futility	0	1	7	3	5	1
all	max_n	0	0	0	0	0	0
all	n	393 (359, 422)	123 (51, 233)	152 (101, 218)	146 (96, 219)	151 (97, 226)	148 (102, 224)
all	n_unique	364 (334, 392)	114 (46, 219)	137 (92, 204)	134 (86, 204)	138 (88, 213)	134 (93, 210)
all	time_trial	36 (36, 36)	36 (7, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
all	time_stop	NA (NA, NA)	5 (3, 6)	7 (4, 30)	8 (6, 18)	14 (8, 24)	7 (5, 11)
all	post_p	NA (NA, NA)	1 (0.69, 1)	0.01 (0, 0.15)	0.01 (0, 0.14)	0.01 (0, 0.16)	0.01 (0, 0.13)
all	rate	0.087 (0.079, 0.094)	0.063 (0.051, 0.08)	0.113 (0.1, 0.13)	0.113 (0.101, 0.128)	0.113 (0.1, 0.128)	0.113 (0.101, 0.129)
AR- & TP53-	graduation	0	357	3	2	3	1
AR- & TP53-	futility	0	1	235	243	218	241
AR- & TP53-	max_n	0	106	39	60	77	57
AR- & TP53-	n	245 (216, 270)	44 (25, 154)	70 (29, 144)	71 (28, 151)	76 (31, 153)	70 (29, 151)
AR- & TP53-	n_unique	230 (203, 253)	42 (24, 147)	62 (27, 135)	65 (26, 141)	69 (28, 144)	63 (28, 141)
AR- & TP53-	time_trial	36 (36, 36)	12 (6, 36)	36 (15, 36)	36 (14, 36)	36 (15, 36)	36 (14, 36)
AR- & TP53-	time_stop	NA (NA, NA)	9 (6, 24)	23 (13, 34)	21 (12, 32)	21 (12, 34)	21 (12, 31)
AR- & TP53-	post_p	NA (NA, NA)	1 (0.98, 1)	0.01 (0, 0.09)	0.01 (0, 0.08)	0.01 (0, 0.08)	0.01 (0, 0.08)
AR- & TP53-	rate	0.074 (0.066, 0.083)	0.041 (0.032, 0.05)	0.115 (0.097, 0.142)	0.114 (0.099, 0.14)	0.113 (0.098, 0.139)	0.113 (0.098, 0.142)
HRD+	graduation	0	26	3	3	2	0
HRD+	futility	0	0	47	66	55	29
HRD+	max_n	0	0	0	0	0	0
HRD+	n	61 (49, 73)	15 (3, 30)	27 (14, 43)	29 (19, 46)	30 (19, 49)	26 (14, 42)
HRD+	n_unique	56 (44, 68)	13 (3, 28)	25 (12, 39)	26 (17, 42)	27 (17, 44)	24 (13, 38)
HRD+	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (31, 36)	36 (34, 36)	36 (36, 36)
HRD+	time_stop	NA (NA, NA)	24 (20, 34)	30 (23, 35)	27 (20, 34)	28 (21, 34)	30 (23, 36)
HRD+	post_p	NA (NA, NA)	0.78 (0.27, 0.99)	0.18 (0.03, 0.53)	0.16 (0.03, 0.53)	0.16 (0.02, 0.53)	0.18 (0.03, 0.55)
HRD+	rate	0.083 (0.066, 0.1)	0.068 (0.041, 0.122)	0.115 (0.088, 0.159)	0.114 (0.09, 0.148)	0.115 (0.09, 0.155)	0.114 (0.088, 0.156)
TP53+	graduation	0	3	6	5	3	6
TP53+	futility	0	34	43	26	24	42
TP53+	max_n	0	0	0	0	0	0
TP53+	n	121 (105, 140)	56 (18, 78)	61 (37, 85)	57 (37, 80)	58 (37, 80)	61 (38, 82)
TP53+	n_unique	110 (95, 128)	51 (15, 71)	56 (34, 78)	52 (33, 72)	53 (34, 73)	55 (34, 75)
TP53+	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
TP53+	time_stop	NA (NA, NA)	18 (13, 28)	18 (12, 28)	23 (15, 31)	21 (16, 30)	18 (12, 32)
TP53+	post_p	NA (NA, NA)	0.5 (0.12, 0.87)	0.48 (0.11, 0.91)	0.5 (0.12, 0.88)	0.49 (0.11, 0.88)	0.48 (0.09, 0.88)
TP53+	rate	0.112 (0.1, 0.13)	0.113 (0.093, 0.14)	0.114 (0.093, 0.14)	0.113 (0.092, 0.14)	0.115 (0.095, 0.141)	0.115 (0.097, 0.144)
TEfus+	graduation	0	5	2	4	1	3
TEfus+	futility	0	4	21	21	18	18
TEfus+	max_n	0	0	0	0	0	0
TEfus+	n	116 (99, 133)	46 (13, 66)	61 (41, 81)	56 (36, 74)	56 (38, 76)	57 (39, 77)
TEfus+	n_unique	106 (91, 123)	41 (12, 60)	55 (38, 75)	50 (32, 67)	51 (34, 71)	53 (35, 69)
TEfus+	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
TEfus+	time_stop	NA (NA, NA)	25 (19, 31)	22 (13, 33)	23 (14, 31)	21 (18, 31)	23 (13, 31)
TEfus+	post_p	NA (NA, NA)	0.69 (0.22, 0.98)	0.26 (0.04, 0.7)	0.25 (0.04, 0.71)	0.26 (0.03, 0.69)	0.23 (0.03, 0.72)
TEfus+	rate	0.098 (0.085, 0.114)	0.091 (0.065, 0.119)	0.114 (0.093, 0.135)	0.113 (0.093, 0.14)	0.114 (0.094, 0.139)	0.115 (0.094, 0.142)
PI3K+	graduation	0	19	2	2	1	0
PI3K+	futility	0	3	46	39	43	66
PI3K+	max_n	0	0	0	0	0	0
PI3K+	n	123 (107, 143)	43 (12, 68)	57 (32, 81)	55 (32, 78)	56 (34, 79)	60 (36, 83)
PI3K+	n_unique	113 (98, 131)	39 (11, 63)	51 (30, 74)	50 (29, 71)	52 (30, 74)	56 (33, 76)
PI3K+	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (27, 36)
PI3K+	time_stop	NA (NA, NA)	20 (12, 31)	24 (17, 33)	24 (16, 31)	25 (18, 34)	17 (11, 32)
PI3K+	post_p	NA (NA, NA)	0.81 (0.26, 0.99)	0.2 (0.02, 0.6)	0.18 (0.02, 0.63)	0.2 (0.02, 0.65)	0.17 (0.02, 0.57)
PI3K+	rate	0.094 (0.082, 0.11)	0.081 (0.058, 0.109)	0.113 (0.095, 0.141)	0.115 (0.093, 0.141)	0.113 (0.094, 0.142)	0.114 (0.097, 0.143)

By subgroup combinations:

subtype	var	Control	TC1	TC2	TC3	TC4	TC5
—–	graduation	0	390	7	6	4	3
—–	futility	0	2	238	244	220	241
—–	max_n	0	106	39	60	77	57
—–	n	145 (123, 166)	32 (19, 109)	24 (10, 82)	27 (8, 93)	30 (8, 97)	26 (8, 91)
—–	n_unique	137 (115, 157)	31 (17, 105)	22 (9, 79)	25 (7, 90)	28 (7, 92)	24 (7, 86)
—–	post_p	NA (NA, NA)	1 (0.93, 1)	0.06 (0, 0.27)	0.06 (0, 0.29)	0.06 (0, 0.27)	0.06 (0, 0.3)
—–	rate	0.074 (0.065, 0.085)	0.042 (0.032, 0.053)	0.12 (0.094, 0.173)	0.116 (0.093, 0.177)	0.115 (0.093, 0.177)	0.117 (0.092, 0.17)
—-+	graduation	0	388	8	8	5	3
—-+	futility	0	4	250	250	232	262
—-+	max_n	0	106	39	59	77	56
—-+	n	32 (24, 42)	5 (2, 21)	10 (3, 24)	9 (3, 25)	9 (3, 25)	10 (5, 26)
—-+	n_unique	30 (22, 39)	5 (2, 20)	9 (3, 22)	8 (3, 23)	8 (3, 23)	9 (5, 25)
—-+	post_p	NA (NA, NA)	0.87 (0.5, 0.99)	0.23 (0.07, 0.56)	0.22 (0.07, 0.49)	0.24 (0.07, 0.56)	0.22 (0.06, 0.59)
—-+	rate	0.074 (0.054, 0.1)	0.041 (0.019, 0.082)	0.124 (0.081, 0.256)	0.128 (0.086, 0.248)	0.128 (0.08, 0.259)	0.118 (0.081, 0.204)
—+-	graduation	0	386	9	8	5	5
—+-	futility	0	6	238	246	221	245
—+-	max_n	0	106	39	60	77	57
—+-	n	5 (2, 9)	1 (0, 4)	3 (0, 6)	2 (0, 6)	2 (0, 6)	2 (0, 5)
—+-	n_unique	5 (2, 8)	1 (0, 3)	3 (0, 5)	2 (0, 5)	2 (0, 5)	2 (0, 5)
—+-	post_p	NA (NA, NA)	0.63 (0.4, 0.86)	0.41 (0.24, 0.65)	0.42 (0.24, 0.64)	0.41 (0.26, 0.66)	0.43 (0.28, 0.63)
—+-	rate	0.075 (0.027, 0.177)	0.045 (0, 0.172)	0.127 (0.054, 0.396)	0.143 (0.051, 0.398)	0.137 (0.049, 0.535)	0.132 (0.051, 0.408)
—++	graduation	0	385	10	10	6	5
—++	futility	0	7	250	252	233	265
—++	max_n	0	106	39	59	77	56
—++	n	14 (9, 20)	2 (0, 8)	5 (1, 13)	5 (1, 12)	5 (1, 12)	6 (2, 13)
—++	n_unique	13 (8, 19)	2 (0, 8)	4 (1, 12)	4 (1, 11)	5 (1, 12)	5 (2, 12)
—++	post_p	NA (NA, NA)	0.73 (0.39, 0.94)	0.35 (0.15, 0.63)	0.35 (0.16, 0.64)	0.37 (0.18, 0.65)	0.34 (0.15, 0.62)
—++	rate	0.076 (0.048, 0.119)	0.048 (0.012, 0.141)	0.127 (0.072, 0.357)	0.134 (0.07, 0.381)	0.127 (0.066, 0.293)	0.125 (0.075, 0.303)
–+–	graduation	0	55	10	9	4	8
–+–	futility	0	35	47	28	28	43
–+–	max_n	0	0	0	0	0	0
–+–	n	26 (19, 35)	10 (3, 24)	11 (4, 23)	10 (4, 23)	10 (4, 21)	10 (4, 22)
–+–	n_unique	23 (16, 33)	9 (3, 22)	10 (3, 21)	9 (3, 22)	9 (3, 20)	9 (3, 21)
–+–	post_p	NA (NA, NA)	0.46 (0.16, 0.83)	0.47 (0.16, 0.85)	0.45 (0.16, 0.83)	0.46 (0.18, 0.85)	0.45 (0.17, 0.85)
–+–	rate	0.113 (0.084, 0.156)	0.124 (0.081, 0.244)	0.123 (0.082, 0.255)	0.125 (0.08, 0.279)	0.122 (0.084, 0.259)	0.124 (0.081, 0.266)
–+-+	graduation	0	74	12	11	5	8
–+-+	futility	0	36	75	58	63	92
–+-+	max_n	0	0	0	0	0	0
–+-+	n	24 (18, 33)	8 (2, 20)	9 (3, 21)	9 (3, 22)	10 (4, 22)	11 (5, 23)
–+-+	n_unique	23 (16, 30)	7 (2, 18)	8 (3, 19)	9 (3, 20)	10 (3, 20)	10 (4, 21)
–+-+	post_p	NA (NA, NA)	0.46 (0.17, 0.82)	0.47 (0.18, 0.85)	0.46 (0.18, 0.85)	0.49 (0.17, 0.85)	0.45 (0.16, 0.82)
–+-+	rate	0.115 (0.086, 0.157)	0.129 (0.077, 0.282)	0.121 (0.077, 0.245)	0.125 (0.076, 0.256)	0.121 (0.08, 0.243)	0.123 (0.088, 0.249)
–++-	graduation	0	60	12	12	5	10
–++-	futility	0	37	62	46	42	54
–++-	max_n	0	0	0	0	0	0
–++-	n	7 (4, 11)	3 (0, 7)	4 (1, 9)	3 (1, 7)	3 (1, 6)	3 (1, 7)
–++-	n_unique	6 (3, 10)	3 (0, 7)	4 (1, 8)	3 (1, 6)	3 (1, 6)	3 (1, 6)
–++-	post_p	NA (NA, NA)	0.46 (0.25, 0.78)	0.47 (0.25, 0.77)	0.48 (0.28, 0.73)	0.48 (0.26, 0.77)	0.48 (0.27, 0.76)
–++-	rate	0.116 (0.064, 0.211)	0.132 (0.061, 0.369)	0.122 (0.061, 0.31)	0.122 (0.057, 0.381)	0.131 (0.052, 0.389)	0.132 (0.057, 0.454)
–+++	graduation	0	78	14	14	6	10
–+++	futility	0	38	88	70	73	99
–+++	max_n	0	0	0	0	0	0
–+++	n	19 (13, 26)	7 (2, 17)	8 (3, 18)	7 (3, 16)	7 (3, 16)	9 (4, 18)
–+++	n_unique	18 (12, 24)	6 (1, 15)	7 (3, 16)	6 (2, 14)	7 (2, 15)	8 (3, 17)
–+++	post_p	NA (NA, NA)	0.48 (0.2, 0.83)	0.44 (0.18, 0.84)	0.46 (0.19, 0.83)	0.45 (0.2, 0.82)	0.45 (0.16, 0.82)
–+++	rate	0.113 (0.084, 0.161)	0.121 (0.071, 0.274)	0.124 (0.079, 0.275)	0.127 (0.075, 0.344)	0.13 (0.078, 0.327)	0.127 (0.081, 0.272)
-+—	graduation	0	394	10	9	6	3
-+—	futility	0	2	259	262	249	251
-+—	max_n	0	102	37	59	76	56
-+—	n	27 (19, 36)	3 (0, 16)	9 (3, 22)	10 (4, 24)	10 (5, 23)	9 (3, 21)
-+—	n_unique	25 (18, 34)	2 (0, 14)	8 (2, 21)	9 (4, 22)	9 (4, 22)	8 (2, 20)
-+—	post_p	NA (NA, NA)	0.81 (0.4, 0.98)	0.27 (0.09, 0.55)	0.26 (0.09, 0.57)	0.25 (0.08, 0.59)	0.27 (0.1, 0.58)
-+—	rate	0.075 (0.054, 0.104)	0.043 (0.016, 0.143)	0.121 (0.084, 0.27)	0.118 (0.081, 0.229)	0.121 (0.078, 0.222)	0.121 (0.079, 0.266)
-+–+	graduation	0	392	10	11	7	3
-+–+	futility	0	4	271	268	259	269
-+–+	max_n	0	102	37	58	76	55
-+–+	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-+–+	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-+–+	post_p	NA (NA, NA)	0.49 (0.49, 0.49)	0.5 (0.44, 0.54)	0.49 (0.49, 0.49)	0.5 (0.49, 0.51)	0.5 (0.48, 0.52)
-+–+	rate	0.246 (0, 0.922)	0.15 (0.03, 0.269)	0.081 (0, 0.478)	0.195 (0, 0.475)	0.14 (0, 1.835)	0.136 (0.037, 0.242)
-+-+-	graduation	0	390	12	11	7	5
-+-+-	futility	0	6	259	263	250	254
-+-+-	max_n	0	102	37	59	76	56
-+-+-	n	13 (8, 19)	1 (0, 6)	5 (1, 12)	5 (2, 12)	5 (2, 12)	5 (1, 11)
-+-+-	n_unique	12 (7, 18)	1 (0, 6)	4 (1, 11)	5 (2, 11)	5 (2, 11)	4 (1, 10)
-+-+-	post_p	NA (NA, NA)	0.73 (0.4, 0.94)	0.35 (0.16, 0.65)	0.34 (0.16, 0.67)	0.34 (0.16, 0.67)	0.37 (0.19, 0.69)
-+-+-	rate	0.075 (0.046, 0.121)	0.048 (0.008, 0.17)	0.128 (0.071, 0.333)	0.127 (0.072, 0.327)	0.132 (0.076, 0.336)	0.131 (0.065, 0.378)
-+-++	graduation	0	389	12	13	8	5
-+-++	futility	0	7	271	269	260	271
-+-++	max_n	0	102	37	58	76	55
-+-++	n	5 (2, 8)	0 (0, 3)	2 (0, 5)	2 (0, 6)	3 (1, 7)	2 (0, 5)
-+-++	n_unique	5 (2, 8)	0 (0, 3)	2 (0, 5)	2 (0, 5)	3 (1, 6)	2 (0, 5)
-+-++	post_p	NA (NA, NA)	0.6 (0.37, 0.82)	0.42 (0.24, 0.64)	0.42 (0.26, 0.66)	0.43 (0.27, 0.67)	0.43 (0.28, 0.67)
-+-++	rate	0.078 (0.03, 0.172)	0.048 (0, 0.237)	0.139 (0.058, 0.473)	0.127 (0.053, 0.422)	0.129 (0.058, 0.399)	0.129 (0.051, 0.424)
-++–	graduation	0	81	13	10	6	8
-++–	futility	0	33	89	91	81	69
-++–	max_n	0	0	0	0	0	0
-++–	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-++–	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-++–	post_p	NA (NA, NA)	0.5 (0.45, 0.58)	0.49 (0.49, 0.49)	0.49 (0.46, 0.52)	0.49 (0.47, 0.52)	0.52 (0.44, 0.54)
-++–	rate	0.103 (0, 0.505)	0.102 (0, 0.516)	0.048 (0, 0.303)	0.152 (0.061, 1.178)	0.168 (0, 0.823)	0.131 (0, 0.523)
-++-+	graduation	0	100	14	12	7	8
-++-+	futility	0	34	115	117	113	111
-++-+	max_n	0	0	0	0	0	0
-++-+	n	2 (0, 5)	1 (0, 3)	1 (0, 4)	2 (0, 4)	2 (0, 4)	1 (0, 3)
-++-+	n_unique	2 (0, 5)	1 (0, 3)	1 (0, 3)	1 (0, 4)	1 (0, 4)	1 (0, 3)
-++-+	post_p	NA (NA, NA)	0.48 (0.34, 0.68)	0.48 (0.32, 0.73)	0.46 (0.3, 0.71)	0.47 (0.3, 0.69)	0.5 (0.33, 0.69)
-++-+	rate	0.126 (0.043, 0.4)	0.133 (0.039, 0.597)	0.133 (0.021, 0.501)	0.145 (0.047, 0.573)	0.143 (0.042, 0.523)	0.129 (0, 0.603)
-+++-	graduation	0	86	15	13	7	10
-+++-	futility	0	35	102	104	94	78
-+++-	max_n	0	0	0	0	0	0
-+++-	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-+++-	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-+++-	post_p	NA (NA, NA)	0.41 (0.41, 0.41)	0.53 (0.49, 0.6)	0.51 (0.48, 0.55)	0.44 (0.42, 0.52)	0.45 (0.45, 0.45)
-+++-	rate	0.144 (0, 4.648)	0.395 (0.177, 1.86)	0.083 (0, 0.645)	0.129 (0.051, 1.96)	0.149 (0, 0.575)	0.138 (0, 0.654)
-++++	graduation	0	104	16	15	8	10
-++++	futility	0	36	127	126	122	116
-++++	max_n	0	0	0	0	0	0
-++++	n	3 (1, 5)	1 (0, 3)	1 (0, 4)	2 (0, 4)	2 (0, 4)	1 (0, 3)
-++++	n_unique	2 (0, 5)	1 (0, 3)	1 (0, 3)	2 (0, 4)	2 (0, 4)	1 (0, 3)
-++++	post_p	NA (NA, NA)	0.47 (0.33, 0.69)	0.47 (0.32, 0.69)	0.49 (0.3, 0.72)	0.49 (0.32, 0.68)	0.47 (0.32, 0.66)
-++++	rate	0.116 (0.033, 0.39)	0.13 (0.031, 0.626)	0.144 (0.027, 0.647)	0.128 (0.038, 0.481)	0.129 (0.044, 0.424)	0.141 (0.044, 0.603)
+—-	graduation	0	52	4	4	1	2
+—-	futility	0	1	7	3	5	1
+—-	max_n	0	0	0	0	0	0
+—-	n	5 (2, 8)	2 (0, 5)	3 (1, 7)	2 (0, 5)	2 (1, 5)	2 (1, 5)
+—-	n_unique	4 (1, 8)	2 (0, 5)	3 (1, 6)	2 (0, 5)	2 (0, 5)	2 (1, 5)
+—-	post_p	NA (NA, NA)	0.45 (0.29, 0.72)	0.47 (0.28, 0.75)	0.48 (0.3, 0.76)	0.47 (0.3, 0.75)	0.5 (0.31, 0.75)
+—-	rate	0.119 (0.055, 0.256)	0.146 (0.051, 0.549)	0.132 (0.053, 0.377)	0.129 (0.045, 0.448)	0.136 (0.043, 0.458)	0.125 (0.045, 0.43)
+—+	graduation	0	71	6	6	2	2
+—+	futility	0	4	50	41	48	66
+—+	max_n	0	0	0	0	0	0
+—+	n	2 (0, 4)	1 (0, 3)	1 (0, 3)	1 (0, 3)	1 (0, 3)	1 (0, 3)
+—+	n_unique	1 (0, 4)	1 (0, 3)	1 (0, 3)	1 (0, 3)	1 (0, 3)	1 (0, 3)
+—+	post_p	NA (NA, NA)	0.49 (0.36, 0.67)	0.49 (0.33, 0.66)	0.48 (0.35, 0.68)	0.48 (0.36, 0.68)	0.48 (0.34, 0.67)
+—+	rate	0.127 (0.035, 0.422)	0.129 (0, 0.543)	0.129 (0, 0.601)	0.127 (0, 0.755)	0.13 (0, 0.679)	0.144 (0.031, 0.628)
+–+-	graduation	0	57	6	8	2	5
+–+-	futility	0	5	25	23	22	19
+–+-	max_n	0	0	0	0	0	0
+–+-	n	7 (4, 12)	3 (1, 8)	5 (2, 9)	3 (1, 8)	3 (1, 7)	3 (1, 7)
+–+-	n_unique	7 (3, 11)	3 (1, 7)	4 (2, 8)	3 (1, 7)	3 (1, 7)	3 (1, 7)
+–+-	post_p	NA (NA, NA)	0.46 (0.24, 0.77)	0.48 (0.22, 0.81)	0.48 (0.28, 0.79)	0.46 (0.25, 0.8)	0.44 (0.25, 0.76)
+–+-	rate	0.111 (0.063, 0.21)	0.127 (0.061, 0.374)	0.123 (0.066, 0.331)	0.126 (0.058, 0.405)	0.132 (0.054, 0.447)	0.134 (0.061, 0.409)
+–++	graduation	0	75	8	10	3	5
+–++	futility	0	7	64	53	60	76
+–++	max_n	0	0	0	0	0	0
+–++	n	3 (1, 6)	2 (0, 4)	2 (0, 5)	2 (0, 4)	2 (0, 4)	2 (0, 5)
+–++	n_unique	3 (1, 6)	2 (0, 4)	2 (0, 5)	2 (0, 4)	1 (0, 4)	2 (0, 5)
+–++	post_p	NA (NA, NA)	0.49 (0.3, 0.69)	0.47 (0.32, 0.74)	0.47 (0.3, 0.73)	0.5 (0.31, 0.73)	0.47 (0.31, 0.73)
+–++	rate	0.122 (0.037, 0.332)	0.129 (0.038, 0.421)	0.125 (0.046, 0.448)	0.134 (0.036, 0.668)	0.124 (0.031, 0.554)	0.133 (0.045, 0.503)
+-+–	graduation	0	55	10	9	4	8
+-+–	futility	0	35	47	28	28	43
+-+–	max_n	0	0	0	0	0	0
+-+–	n	1 (0, 3)	1 (0, 2)	1 (0, 2)	1 (0, 2)	1 (0, 2)	1 (0, 2)
+-+–	n_unique	1 (0, 3)	1 (0, 2)	1 (0, 2)	1 (0, 2)	1 (0, 2)	1 (0, 2)
+-+–	post_p	NA (NA, NA)	0.49 (0.39, 0.65)	0.48 (0.35, 0.63)	0.48 (0.37, 0.62)	0.49 (0.37, 0.67)	0.48 (0.39, 0.63)
+-+–	rate	0.128 (0, 0.467)	0.129 (0, 0.727)	0.144 (0, 0.76)	0.141 (0, 0.832)	0.139 (0, 0.657)	0.141 (0, 0.585)
+-+-+	graduation	0	74	12	11	5	8
+-+-+	futility	0	36	75	58	63	92
+-+-+	max_n	0	0	0	0	0	0
+-+-+	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+-+-+	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+-+-+	post_p	NA (NA, NA)	NA (NA, NA)	0.48 (0.48, 0.48)	0.53 (0.5, 0.54)	0.47 (0.45, 0.52)	0.45 (0.44, 0.52)
+-+-+	rate	0.159 (0, 0.723)	0.187 (0, 0.38)	0.091 (0, 0.697)	0.11 (0, 1.446)	0.157 (0, 0.498)	0.152 (0, 0.657)
+-++-	graduation	0	60	12	12	5	10
+-++-	futility	0	37	62	46	42	54
+-++-	max_n	0	0	0	0	0	0
+-++-	n	20 (14, 27)	8 (2, 18)	10 (4, 20)	8 (3, 18)	8 (3, 19)	8 (3, 19)
+-++-	n_unique	18 (13, 26)	7 (2, 16)	10 (4, 19)	7 (2, 16)	7 (3, 17)	8 (2, 17)
+-++-	post_p	NA (NA, NA)	0.49 (0.18, 0.83)	0.47 (0.18, 0.87)	0.46 (0.2, 0.82)	0.45 (0.19, 0.82)	0.47 (0.17, 0.85)
+-++-	rate	0.115 (0.083, 0.162)	0.125 (0.077, 0.291)	0.122 (0.08, 0.248)	0.125 (0.076, 0.294)	0.128 (0.078, 0.278)	0.125 (0.076, 0.329)
+-+++	graduation	0	78	14	14	6	10
+-+++	futility	0	38	88	70	73	99
+-+++	max_n	0	0	0	0	0	0
+-+++	n	16 (10, 22)	6 (1, 14)	7 (3, 15)	7 (2, 15)	6 (3, 15)	7 (3, 15)
+-+++	n_unique	14 (9, 21)	5 (1, 12)	7 (2, 14)	6 (2, 14)	6 (2, 13)	6 (2, 14)
+-+++	post_p	NA (NA, NA)	0.47 (0.2, 0.82)	0.48 (0.21, 0.84)	0.47 (0.22, 0.86)	0.46 (0.2, 0.8)	0.45 (0.19, 0.8)
+-+++	rate	0.111 (0.079, 0.174)	0.129 (0.071, 0.339)	0.122 (0.071, 0.285)	0.12 (0.072, 0.304)	0.131 (0.075, 0.327)	0.125 (0.078, 0.293)
++—	graduation	0	78	7	7	3	2
++—	futility	0	1	54	69	60	30
++—	max_n	0	0	0	0	0	0
++—	n	8 (4, 12)	3 (0, 7)	3 (1, 8)	4 (2, 9)	4 (2, 9)	4 (1, 8)
++—	n_unique	7 (4, 11)	3 (0, 7)	3 (1, 8)	4 (2, 8)	4 (2, 8)	3 (1, 7)
++—	post_p	NA (NA, NA)	0.46 (0.26, 0.78)	0.46 (0.27, 0.76)	0.46 (0.24, 0.76)	0.46 (0.23, 0.78)	0.46 (0.27, 0.8)
++—	rate	0.112 (0.066, 0.209)	0.134 (0.062, 0.386)	0.131 (0.062, 0.428)	0.134 (0.066, 0.345)	0.13 (0.069, 0.376)	0.134 (0.049, 0.436)
++–+	graduation	0	97	8	9	4	2
++–+	futility	0	4	93	103	99	87
++–+	max_n	0	0	0	0	0	0
++–+	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++–+	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++–+	post_p	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.51 (0.51, 0.51)	0.52 (0.48, 0.55)
++–+	rate	0.173 (0, 1.48)	0 (0, 1.517)	0 (0, 0.185)	0.172 (0, 2.691)	0.151 (0, 0.58)	0.112 (0, 0.6)
++-+-	graduation	0	83	9	11	4	5
++-+-	futility	0	5	69	84	76	45
++-+-	max_n	0	0	0	0	0	0
++-+-	n	1 (0, 2)	0 (0, 2)	0 (0, 2)	1 (0, 2)	1 (0, 2)	0 (0, 2)
++-+-	n_unique	1 (0, 2)	0 (0, 2)	0 (0, 2)	0 (0, 2)	0 (0, 2)	0 (0, 2)
++-+-	post_p	NA (NA, NA)	0.49 (0.39, 0.65)	0.49 (0.39, 0.61)	0.5 (0.39, 0.6)	0.48 (0.39, 0.65)	0.48 (0.38, 0.62)
++-+-	rate	0.138 (0, 0.639)	0.125 (0, 0.583)	0.141 (0, 0.83)	0.135 (0, 0.946)	0.14 (0, 0.76)	0.151 (0, 0.613)
++-++	graduation	0	101	10	13	5	5
++-++	futility	0	7	106	112	110	94
++-++	max_n	0	0	0	0	0	0
++-++	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++-++	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++-++	post_p	NA (NA, NA)	0.55 (0.55, 0.55)	0.43 (0.43, 0.43)	0.52 (0.51, 0.57)	0.48 (0.47, 0.48)	0.42 (0.42, 0.42)
++-++	rate	0.129 (0, 1.03)	0.066 (0, 0.643)	0.188 (0, 0.613)	0.16 (0, 1.287)	0.182 (0.019, 1.281)	0.076 (0, 0.67)
+++–	graduation	0	81	13	10	6	8
+++–	futility	0	33	89	91	81	69
+++–	max_n	0	0	0	0	0	0
+++–	n	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)
+++–	n_unique	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)
+++–	post_p	NA (NA, NA)	0.5 (0.41, 0.57)	0.53 (0.45, 0.58)	0.5 (0.45, 0.55)	0.49 (0.43, 0.62)	0.47 (0.38, 0.55)
+++–	rate	0.135 (0, 0.826)	0.133 (0, 0.571)	0.096 (0, 0.71)	0.125 (0, 1.673)	0.149 (0, 0.919)	0.189 (0, 1.569)
+++-+	graduation	0	100	14	12	7	8
+++-+	futility	0	34	115	117	113	111
+++-+	max_n	0	0	0	0	0	0
+++-+	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++-+	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++-+	post_p	NA (NA, NA)	0.44 (0.44, 0.44)	NA (NA, NA)	0.52 (0.48, 0.56)	NA (NA, NA)	0.53 (0.49, 0.54)
+++-+	rate	0.117 (0, 1.06)	0.162 (0, 1.627)	0.115 (0, 0.485)	0.121 (0, 3.302)	0.193 (0, 0.788)	0.124 (0, 0.527)
++++-	graduation	0	86	15	13	7	10
++++-	futility	0	35	102	104	94	78
++++-	max_n	0	0	0	0	0	0
++++-	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++++-	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++++-	post_p	NA (NA, NA)	0.5 (0.47, 0.53)	0.52 (0.48, 0.55)	0.44 (0.44, 0.44)	0.46 (0.41, 0.47)	0.45 (0.45, 0.45)
++++-	rate	0.212 (0.044, 0.599)	0.089 (0, 0.855)	0.221 (0, 0.592)	0.214 (0, 1.016)	0.198 (0, 2.152)	0.183 (0.035, 1.539)
+++++	graduation	0	104	16	15	8	10
+++++	futility	0	36	127	126	122	116
+++++	max_n	0	0	0	0	0	0
+++++	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++++	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++++	post_p	NA (NA, NA)	0.46 (0.42, 0.47)	NA (NA, NA)	0.6 (0.6, 0.6)	0.5 (0.47, 0.53)	0.5 (0.47, 0.53)
+++++	rate	0.076 (0, 0.253)	0.126 (0.029, 0.378)	0.115 (0, 0.506)	0.163 (0, 0.585)	0.146 (0, 0.611)	0.148 (0, 0.492)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates

Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:

signature	var	TC1	TC2	TC3	TC4	TC5
all	count	52	4	4	1	2
all	time_stop	5 (3, 6)	6 (5, 7)	6 (6, 8)	8 (8, 8)	6 (5, 7)
all	n_trt	32 (25, 41)	30 (26, 32)	28 (26, 34)	43 (43, 43)	29 (26, 32)
all	n_control	49 (33, 63)	56 (51, 57)	59 (51, 62)	82 (82, 82)	54 (51, 57)
all	post_p	0.92 (0.86, 0.98)	0.92 (0.89, 0.96)	0.91 (0.89, 0.91)	0.92 (0.92, 0.92)	0.89 (0.86, 0.91)
all	order	1 (1, 1)	1 (1, 1)	1 (1, 1)	1 (1, 1)	1.5 (1.1, 1.9)
AR- & TP53-	count	357	3	2	3	1
AR- & TP53-	time_stop	9 (6, 24)	10 (9, 14)	10 (10, 11)	13 (10, 16)	9 (9, 9)
AR- & TP53-	n_trt	38 (26, 132)	26 (25, 40)	40 (34, 47)	30 (27, 54)	28 (28, 28)
AR- & TP53-	n_control	47 (31, 140)	56 (44, 69)	54 (48, 60)	80 (49, 90)	42 (42, 42)
AR- & TP53-	post_p	0.97 (0.89, 1)	0.9 (0.89, 0.92)	0.89 (0.89, 0.9)	0.92 (0.9, 0.96)	0.98 (0.98, 0.98)
AR- & TP53-	order	1 (1, 2)	1 (1, 1.8)	2 (1.2, 2.8)	1 (1, 1.8)	1 (1, 1)
HRD+	count	26	3	3	2
HRD+	time_stop	24 (20, 34)	23 (18, 27)	22 (17, 23)	24 (22, 27)
HRD+	n_trt	26 (25, 28)	27 (25, 34)	29 (27, 31)	32 (28, 35)
HRD+	n_control	35 (27, 48)	32 (31, 34)	34 (24, 43)	30 (27, 34)
HRD+	post_p	0.98 (0.9, 1)	0.97 (0.94, 0.98)	0.93 (0.88, 0.97)	0.96 (0.93, 0.99)
HRD+	order	1 (1, 2)	2 (2, 2)	2 (2, 2.8)	1.5 (1.1, 1.9)
TP53+	count	3	6	5	3	6
TP53+	time_stop	17 (14, 24)	12 (11, 16)	15 (11, 18)	17 (15, 22)	14 (11, 25)
TP53+	n_trt	28 (27, 50)	26 (26, 31)	26 (25, 28)	36 (30, 38)	32 (26, 52)
TP53+	n_control	51 (40, 91)	37 (34, 42)	43 (30, 56)	44 (40, 67)	34 (28, 72)
TP53+	post_p	0.98 (0.92, 0.99)	0.96 (0.92, 0.98)	0.96 (0.94, 0.96)	0.97 (0.9, 0.98)	0.96 (0.94, 0.98)
TP53+	order	2 (1.2, 2)	1 (1, 1.5)	2 (1.4, 2.6)	1 (1, 1)	2 (1, 3)
TEfus+	count	5	2	4	1	3
TEfus+	time_stop	21 (17, 29)	12 (11, 13)	16 (14, 17)	16 (16, 16)	13 (11, 13)
TEfus+	n_trt	34 (27, 45)	30 (28, 32)	30 (28, 32)	30 (30, 30)	27 (26, 30)
TEfus+	n_control	56 (41, 89)	30 (24, 35)	38 (28, 46)	36 (36, 36)	26 (26, 32)
TEfus+	post_p	0.98 (0.95, 1)	0.97 (0.97, 0.98)	0.92 (0.87, 0.98)	0.96 (0.96, 0.96)	0.97 (0.92, 0.97)
TEfus+	order	2 (2, 2)	2 (2, 2)	1.5 (1, 2)	1 (1, 1)	2 (1.2, 2)
PI3K+	count	19	2	2	1
PI3K+	time_stop	19 (13, 30)	14 (12, 16)	16 (14, 18)	20 (20, 20)
PI3K+	n_trt	30 (25, 55)	30 (26, 33)	28 (26, 30)	28 (28, 28)
PI3K+	n_control	55 (33, 96)	38 (32, 44)	46 (44, 48)	62 (62, 62)
PI3K+	post_p	0.98 (0.93, 1)	0.97 (0.94, 0.99)	0.92 (0.89, 0.94)	0.99 (0.99, 0.99)
PI3K+	order	2 (1, 2.2)	2 (1.2, 2.8)	2 (2, 2)	1 (1, 1)

Futility:

signature	var	TC1	TC2	TC3	TC4	TC5
all	count	1	7	3	5	1
all	time_stop	5 (5, 5)	10 (5, 31)	16 (10, 19)	19 (8, 24)	12 (12, 12)
all	n_trt	31 (31, 31)	50 (27, 88)	59 (33, 75)	56 (29, 70)	52 (52, 52)
all	n_control	46 (46, 46)	84 (51, 330)	136 (90, 174)	165 (60, 266)	107 (107, 107)
all	post_p	0.24 (0.24, 0.24)	0 (0, 0.09)	0 (0, 0.01)	0.01 (0, 0.02)	0 (0, 0)
all	order	1 (1, 1)	1 (1, 5.8)	2 (1.2, 2.8)	2 (1, 4.4)	2 (2, 2)
AR- & TP53-	count	1	235	243	218	241
AR- & TP53-	time_stop	4 (4, 4)	23 (13, 34)	22 (12, 32)	22 (13, 34)	21 (12, 31)
AR- & TP53-	n_trt	26 (26, 26)	45 (27, 100)	46 (26, 108)	44 (27, 100)	44 (26, 101)
AR- & TP53-	n_control	27 (27, 27)	145 (67, 233)	125 (61, 213)	132 (65, 232)	120 (63, 207)
AR- & TP53-	post_p	0.24 (0.24, 0.24)	0.01 (0, 0.1)	0.02 (0, 0.11)	0.02 (0, 0.14)	0.03 (0, 0.15)
AR- & TP53-	order	1 (1, 1)	2 (1, 4.6)	2 (1, 4)	2 (1, 4)	2 (1, 4)
HRD+	count		47	66	55	29
HRD+	time_stop		32 (23, 35)	27 (20, 34)	28 (21, 34)	30 (23, 36)
HRD+	n_trt		27 (25, 39)	28 (25, 40)	29 (25, 36)	28 (25, 42)
HRD+	n_control		50 (34, 65)	44 (24, 56)	42 (25, 64)	49 (33, 60)
HRD+	post_p		0.09 (0.02, 0.24)	0.09 (0.03, 0.25)	0.08 (0.01, 0.25)	0.08 (0.04, 0.25)
HRD+	order		3 (2, 6)	3 (2, 5)	3 (1, 5.6)	4 (2, 5)
TP53+	count	34	43	26	24	42
TP53+	time_stop	18 (12, 29)	19 (15, 29)	24 (19, 31)	22 (17, 30)	21 (13, 32)
TP53+	n_trt	28 (25, 43)	32 (25, 50)	32 (26, 44)	31 (25, 42)	31 (25, 49)
TP53+	n_control	54 (37, 90)	60 (38, 104)	76 (51, 112)	61 (45, 105)	62 (37, 111)
TP53+	post_p	0.08 (0.02, 0.17)	0.07 (0.03, 0.19)	0.06 (0.01, 0.2)	0.08 (0.02, 0.21)	0.11 (0.01, 0.25)
TP53+	order	2 (1, 3.7)	2 (1, 3.8)	3 (1, 4.5)	2 (1, 4)	2 (1, 4)
TEfus+	count	4	21	21	18	18
TEfus+	time_stop	26 (24, 33)	22 (15, 33)	24 (16, 32)	22 (19, 31)	24 (13, 31)
TEfus+	n_trt	30 (28, 40)	33 (27, 52)	35 (26, 40)	32 (26, 43)	29 (25, 45)
TEfus+	n_control	84 (79, 122)	74 (37, 107)	74 (42, 98)	61 (46, 111)	72 (36, 118)
TEfus+	post_p	0.05 (0.01, 0.22)	0.04 (0.01, 0.13)	0.02 (0, 0.07)	0.05 (0.01, 0.09)	0.02 (0, 0.13)
TEfus+	order	3.5 (2, 5)	4 (2, 7)	4 (2, 5)	3 (1, 4.3)	4 (1.7, 6)
PI3K+	count	3	46	39	43	66
PI3K+	time_stop	23 (14, 31)	24 (17, 33)	25 (17, 31)	25 (18, 35)	17 (11, 32)
PI3K+	n_trt	28 (26, 33)	32 (25, 52)	30 (25, 49)	34 (26, 52)	33 (26, 54)
PI3K+	n_control	71 (45, 105)	70 (44, 109)	81 (45, 104)	81 (54, 118)	52 (29, 114)
PI3K+	post_p	0.12 (0.08, 0.16)	0.05 (0, 0.12)	0.05 (0, 0.14)	0.03 (0, 0.13)	0.04 (0.01, 0.18)
PI3K+	order	4 (3.2, 4)	3 (1.5, 4)	3 (1.8, 4.2)	3 (1, 6)	2 (1, 5)

By subgroup combinations

Graduation:

signature	treatment	var	—–	—-+	—+-	—++	–+–	–+-+	–++-	–+++	-+—	-+–+	-+-+-	-+-++	-++–	-++-+	-+++-	-++++	+—-	+—+	+–+-	+–++	+-+–	+-+-+	+-++-	+-+++	++—	++–+	++-+-	++-++	+++–	+++-+	++++-	+++++
all	TC1	count	52	52	52	52	52	52	52	52	52	52	52	52	52	52	52	52	52	52	52	52	52	52	52	52	52	52	52	52	52	52	52	52
all	TC1	time	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)
all	TC1	n	18 (14, 23)	2 (0, 4)	0 (0, 2)	1 (0, 4)	2 (1, 5)	1 (0, 3)	0 (0, 2)	1 (0, 2)	0 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 1)	0 (0, 1)	0 (0, 2)	0 (0, 1)	0 (0, 1)	0 (0, 0)	1 (0, 2)	0 (0, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC1	post_p	0.65 (0.55, 0.81)	0.57 (0.51, 0.66)	0.52 (0.5, 0.54)	0.53 (0.51, 0.62)	0.55 (0.51, 0.6)	0.54 (0.51, 0.63)	0.53 (0.51, 0.58)	0.54 (0.51, 0.58)	0.53 (0.52, 0.59)	NA (NA, NA)	0.52 (0.51, 0.57)	0.55 (0.52, 0.55)	NA (NA, NA)	0.53 (0.53, 0.54)	NA (NA, NA)	NA (NA, NA)	0.55 (0.51, 0.56)	0.51 (0.5, 0.51)	0.52 (0.5, 0.62)	0.53 (0.53, 0.54)	NA (NA, NA)	NA (NA, NA)	0.54 (0.51, 0.6)	0.54 (0.51, 0.57)	0.54 (0.53, 0.56)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC1	r_prob	0.41 (0.41, 0.41)	0.22 (0.22, 0.22)	0.37 (0.37, 0.37)	0.22 (0.22, 0.22)	0.31 (0.31, 0.31)	0.13 (0.13, 0.13)	0.18 (0.18, 0.18)	0.09 (0.09, 0.09)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.14 (0.14, 0.14)	0.18 (0.18, 0.18)	0.14 (0.14, 0.14)	0.12 (0.12, 0.12)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC1	rate	0.029 (0, 0.06)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0.109)	0 (0, 0.11)	0 (0, 0.176)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	0 (0, 0.93)	0 (0, 0.117)	0 (0, 0)	0 (0, 0.048)	0 (0, 0.25)	0 (0, 1.516)	NA (NA, NA)	0 (0, 0.055)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	0.185 (0.185, 0.185)	NA (NA, NA)	NA (NA, NA)
all	TC2	count	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4
all	TC2	time	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)
all	TC2	n	11 (8, 15)	0 (0, 3)	1 (1, 2)	0 (0, 1)	2 (1, 3)	0 (0, 1)	0 (0, 1)	1 (0, 1)	0 (0, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 1)	0 (0, 1)	1 (0, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	5 (4, 6)	3 (2, 4)	1 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC2	post_p	0.72 (0.57, 0.85)	0.52 (0.51, 0.52)	0.51 (0.51, 0.51)	0.52 (0.52, 0.52)	0.55 (0.51, 0.57)	0.52 (0.52, 0.52)	0.66 (0.66, 0.66)	0.51 (0.51, 0.51)	0.55 (0.53, 0.57)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.51 (0.51, 0.51)	NA (NA, NA)	0.56 (0.55, 0.58)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.57 (0.52, 0.65)	0.53 (0.51, 0.59)	0.51 (0.51, 0.51)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC2	r_prob	0.18 (0.18, 0.18)	0.03 (0.03, 0.03)	0.25 (0.25, 0.25)	0.03 (0.03, 0.03)	0.17 (0.17, 0.17)	0.07 (0.07, 0.07)	0.41 (0.41, 0.41)	0.16 (0.16, 0.16)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.29 (0.29, 0.29)	0.41 (0.41, 0.41)	0.29 (0.29, 0.29)	0.37 (0.37, 0.37)	0.21 (0.21, 0.21)	0.37 (0.37, 0.37)	0.21 (0.21, 0.21)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC2	rate	0.019 (0, 0.075)	0.045 (0.009, 0.081)	0 (0, 0.157)	0 (0, 0)	0 (0, 0.059)	0 (0, 0)	0.115 (0.115, 0.115)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.027 (0, 0.06)	0 (0, 0.076)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC3	count	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4
all	TC3	time	6 (6, 8)	6 (6, 8)	6 (6, 8)	6 (6, 8)	6 (6, 8)	6 (6, 8)	6 (6, 8)	6 (6, 8)	6 (6, 8)	6 (6, 8)	6 (6, 8)	6 (6, 8)	6 (6, 8)	6 (6, 8)	6 (6, 8)	6 (6, 8)	6 (6, 8)	6 (6, 8)	6 (6, 8)	6 (6, 8)	6 (6, 8)	6 (6, 8)	6 (6, 8)	6 (6, 8)	6 (6, 8)	6 (6, 8)	6 (6, 8)	6 (6, 8)	6 (6, 8)	6 (6, 8)	6 (6, 8)	6 (6, 8)
all	TC3	n	6 (4, 10)	2 (1, 3)	0 (0, 1)	0 (0, 1)	2 (1, 3)	2 (1, 3)	0 (0, 0)	0 (0, 1)	7 (4, 8)	0 (0, 0)	1 (0, 3)	0 (0, 1)	0 (0, 0)	0 (0, 2)	0 (0, 0)	0 (0, 1)	0 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 1)	0 (0, 0)	0 (0, 0)	2 (1, 3)	1 (0, 3)	0 (0, 3)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC3	post_p	0.58 (0.55, 0.68)	0.52 (0.51, 0.55)	NA (NA, NA)	0.54 (0.54, 0.54)	0.52 (0.51, 0.54)	0.53 (0.52, 0.57)	NA (NA, NA)	0.55 (0.52, 0.57)	0.55 (0.52, 0.57)	NA (NA, NA)	0.63 (0.63, 0.63)	0.53 (0.53, 0.53)	NA (NA, NA)	0.67 (0.67, 0.67)	NA (NA, NA)	NA (NA, NA)	0.54 (0.54, 0.54)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.62 (0.55, 0.7)	0.53 (0.52, 0.54)	0.55 (0.54, 0.56)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC3	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
all	TC3	rate	0 (0, 0.05)	0 (0, 0.055)	0 (0, 0)	0 (0, 0)	0.056 (0, 0.166)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0.034 (0.01, 0.042)	NA (NA, NA)	0 (0, 0.51)	0.138 (0.138, 0.138)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0.057 (0.011, 0.103)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	2.421 (2.421, 2.421)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC4	count	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
all	TC4	time	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)
all	TC4	n	6 (6, 6)	0 (0, 0)	0 (0, 0)	2 (2, 2)	5 (5, 5)	1 (1, 1)	1 (1, 1)	0 (0, 0)	8 (8, 8)	0 (0, 0)	7 (7, 7)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	1 (1, 1)	1 (1, 1)	0 (0, 0)	0 (0, 0)	6 (6, 6)	2 (2, 2)	3 (3, 3)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC4	post_p	0.55 (0.55, 0.55)	NA (NA, NA)	NA (NA, NA)	0.58 (0.58, 0.58)	0.56 (0.56, 0.56)	0.55 (0.55, 0.55)	0.55 (0.55, 0.55)	NA (NA, NA)	0.64 (0.64, 0.64)	NA (NA, NA)	0.52 (0.52, 0.52)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.57 (0.57, 0.57)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.7 (0.7, 0.7)	0.63 (0.63, 0.63)	0.76 (0.76, 0.76)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC4	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
all	TC4	rate	0.054 (0.054, 0.054)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0.163 (0.163, 0.163)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0.088 (0.088, 0.088)	NA (NA, NA)	0.229 (0.229, 0.229)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC5	count	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2
all	TC5	time	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)
all	TC5	n	2 (1, 2)	4 (3, 4)	0 (0, 1)	6 (4, 8)	2 (0, 3)	8 (6, 10)	0 (0, 0)	2 (2, 2)	1 (1, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 1)	0 (0, 0)	2 (1, 2)	2 (1, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC5	post_p	0.54 (0.53, 0.55)	0.65 (0.63, 0.68)	0.52 (0.52, 0.52)	0.56 (0.53, 0.59)	0.61 (0.61, 0.61)	0.51 (0.51, 0.51)	NA (NA, NA)	0.55 (0.53, 0.57)	0.52 (0.51, 0.52)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.54 (0.54, 0.54)	NA (NA, NA)	NA (NA, NA)	0.54 (0.52, 0.55)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.52 (0.52, 0.52)	0.52 (0.52, 0.52)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC5	r_prob	0 (0, 0)	0.38 (0.38, 0.38)	0 (0, 0)	0.38 (0.38, 0.38)	0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0 (0, 0)	0.38 (0.38, 0.38)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC5	rate	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.015 (0.003, 0.027)	0 (0, 0)	0.063 (0.039, 0.086)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	0.38 (0.26, 0.501)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
AR- & TP53-	TC1	count	357	357	357	357					357	357	357	357
AR- & TP53-	TC1	time	9 (6, 24)	9 (6, 24)	9 (6, 24)	9 (6, 24)					9 (6, 24)	9 (6, 24)	9 (6, 24)	9 (6, 24)
AR- & TP53-	TC1	n	27 (19, 85)	4 (2, 15)	1 (0, 3)	2 (0, 6)					2 (0, 11)	0 (0, 0)	1 (0, 4)	0 (0, 2)
AR- & TP53-	TC1	post_p	0.86 (0.74, 1)	0.61 (0.52, 0.9)	0.54 (0.51, 0.68)	0.57 (0.51, 0.85)					0.58 (0.52, 0.89)	NA (NA, NA)	0.57 (0.51, 0.84)	0.56 (0.51, 0.71)
AR- & TP53-	TC1	r_prob	0.41 (0.41, 0.41)	0.22 (0.22, 0.22)	0.37 (0.37, 0.37)	0.22 (0.22, 0.22)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC1	rate	0.037 (0.015, 0.055)	0.017 (0, 0.079)	0 (0, 0.11)	0 (0, 0.081)					0 (0, 0.066)	0.299 (0.299, 0.299)	0 (0, 0.089)	0 (0, 0.09)
AR- & TP53-	TC2	count	3	3	3	3					3	3	3	3
AR- & TP53-	TC2	time	10 (9, 14)	10 (9, 14)	10 (9, 14)	10 (9, 14)					10 (9, 14)	10 (9, 14)	10 (9, 14)	10 (9, 14)
AR- & TP53-	TC2	n	20 (18, 30)	3 (1, 4)	1 (0, 1)	2 (1, 3)					3 (1, 3)	0 (0, 0)	1 (0, 2)	0 (0, 1)
AR- & TP53-	TC2	post_p	0.85 (0.79, 0.92)	0.55 (0.53, 0.6)	NA (NA, NA)	0.62 (0.59, 0.67)					0.52 (0.51, 0.52)	NA (NA, NA)	0.57 (0.55, 0.58)	NA (NA, NA)
AR- & TP53-	TC2	r_prob	0.18 (0.18, 0.18)	0.03 (0.03, 0.03)	0.25 (0.25, 0.25)	0.03 (0.03, 0.03)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC2	rate	0.055 (0.033, 0.063)	0.055 (0.011, 0.076)	0.546 (0.109, 0.983)	0 (0, 0)					0.131 (0.122, 0.14)	NA (NA, NA)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC3	count	2	2	2	2					2	2	2	2
AR- & TP53-	TC3	time	10 (10, 11)	10 (10, 11)	10 (10, 11)	10 (10, 11)					10 (10, 11)	10 (10, 11)	10 (10, 11)	10 (10, 11)
AR- & TP53-	TC3	n	26 (23, 29)	4 (4, 5)	0 (0, 0)	0 (0, 1)					6 (1, 11)	0 (0, 0)	3 (2, 4)	0 (0, 1)
AR- & TP53-	TC3	post_p	0.84 (0.82, 0.85)	0.69 (0.68, 0.7)	NA (NA, NA)	0.52 (0.52, 0.52)					0.78 (0.78, 0.78)	NA (NA, NA)	0.56 (0.54, 0.58)	0.54 (0.54, 0.54)
AR- & TP53-	TC3	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
AR- & TP53-	TC3	rate	0.049 (0.044, 0.054)	0.029 (0.006, 0.051)	NA (NA, NA)	0 (0, 0)					0.049 (0.049, 0.049)	NA (NA, NA)	0.028 (0.006, 0.05)	0 (0, 0)
AR- & TP53-	TC4	count	3	3	3	3					3	3	3	3
AR- & TP53-	TC4	time	13 (10, 16)	13 (10, 16)	13 (10, 16)	13 (10, 16)					13 (10, 16)	13 (10, 16)	13 (10, 16)	13 (10, 16)
AR- & TP53-	TC4	n	13 (9, 26)	8 (3, 9)	1 (0, 3)	5 (3, 5)					3 (3, 5)	0 (0, 0)	4 (3, 6)	1 (1, 3)
AR- & TP53-	TC4	post_p	0.75 (0.75, 0.78)	0.77 (0.62, 0.8)	0.57 (0.54, 0.6)	0.59 (0.53, 0.64)					0.5 (0.5, 0.53)	NA (NA, NA)	0.61 (0.53, 0.76)	0.52 (0.51, 0.53)
AR- & TP53-	TC4	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
AR- & TP53-	TC4	rate	0.047 (0.009, 0.066)	0.053 (0.011, 0.057)	0.045 (0.009, 0.081)	0.064 (0.04, 0.104)					0.051 (0.048, 0.097)	NA (NA, NA)	0.052 (0.043, 0.073)	0 (0, 0.03)
AR- & TP53-	TC5	count	1	1	1	1					1	1	1	1
AR- & TP53-	TC5	time	9 (9, 9)	9 (9, 9)	9 (9, 9)	9 (9, 9)					9 (9, 9)	9 (9, 9)	9 (9, 9)	9 (9, 9)
AR- & TP53-	TC5	n	14 (14, 14)	5 (5, 5)	0 (0, 0)	5 (5, 5)					4 (4, 4)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC5	post_p	0.9 (0.9, 0.9)	0.54 (0.54, 0.54)	NA (NA, NA)	0.65 (0.65, 0.65)					0.7 (0.7, 0.7)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
AR- & TP53-	TC5	r_prob	0 (0, 0)	0.38 (0.38, 0.38)	0 (0, 0)	0.38 (0.38, 0.38)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC5	rate	0 (0, 0)	0.114 (0.114, 0.114)	NA (NA, NA)	0 (0, 0)					0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC1	count									26	26	26	26	26	26	26	26									26	26	26	26	26	26	26	26
HRD+	TC1	time									24 (20, 34)	24 (20, 34)	24 (20, 34)	24 (20, 34)	24 (20, 34)	24 (20, 34)	24 (20, 34)	24 (20, 34)									24 (20, 34)	24 (20, 34)	24 (20, 34)	24 (20, 34)	24 (20, 34)	24 (20, 34)	24 (20, 34)	24 (20, 34)
HRD+	TC1	n									13 (9, 16)	0 (0, 0)	5 (2, 9)	2 (0, 4)	0 (0, 0)	0 (0, 2)	0 (0, 0)	1 (0, 4)									3 (1, 5)	0 (0, 0)	0 (0, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC1	post_p									0.92 (0.74, 0.97)	NA (NA, NA)	0.78 (0.54, 0.94)	0.6 (0.56, 0.78)	NA (NA, NA)	0.56 (0.5, 0.74)	NA (NA, NA)	0.56 (0.51, 0.84)									0.6 (0.51, 0.85)	NA (NA, NA)	0.58 (0.54, 0.67)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC1	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC1	rate									0.036 (0.019, 0.062)	NA (NA, NA)	0.034 (0.004, 0.078)	0 (0, 0.095)	0 (0, 0)	0.093 (0, 0.19)	0 (0, 0)	0.022 (0, 0.122)									0.066 (0, 0.119)	NA (NA, NA)	0.137 (0, 0.211)	NA (NA, NA)	0.252 (0.252, 0.252)	3.182 (3.182, 3.182)	NA (NA, NA)	0.219 (0.219, 0.219)
HRD+	TC2	count									3	3	3	3	3	3	3	3									3	3	3	3	3	3	3	3
HRD+	TC2	time									23 (18, 27)	23 (18, 27)	23 (18, 27)	23 (18, 27)	23 (18, 27)	23 (18, 27)	23 (18, 27)	23 (18, 27)									23 (18, 27)	23 (18, 27)	23 (18, 27)	23 (18, 27)	23 (18, 27)	23 (18, 27)	23 (18, 27)	23 (18, 27)
HRD+	TC2	n									14 (8, 15)	0 (0, 0)	5 (5, 6)	3 (2, 5)	0 (0, 0)	1 (1, 3)	0 (0, 0)	4 (1, 5)									3 (2, 4)	0 (0, 0)	0 (0, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC2	post_p									0.85 (0.8, 0.88)	NA (NA, NA)	0.7 (0.64, 0.74)	0.62 (0.54, 0.75)	NA (NA, NA)	0.61 (0.54, 0.69)	NA (NA, NA)	0.92 (0.92, 0.92)									0.67 (0.63, 0.71)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC2	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC2	rate									0.038 (0.03, 0.045)	NA (NA, NA)	0.055 (0.047, 0.062)	0 (0, 0.033)	NA (NA, NA)	0 (0, 0.019)	NA (NA, NA)	0.128 (0.053, 0.203)									0.089 (0.018, 0.117)	NA (NA, NA)	0.325 (0.325, 0.325)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC3	count									3	3	3	3	3	3	3	3									3	3	3	3	3	3	3	3
HRD+	TC3	time									22 (17, 23)	22 (17, 23)	22 (17, 23)	22 (17, 23)	22 (17, 23)	22 (17, 23)	22 (17, 23)	22 (17, 23)									22 (17, 23)	22 (17, 23)	22 (17, 23)	22 (17, 23)	22 (17, 23)	22 (17, 23)	22 (17, 23)	22 (17, 23)
HRD+	TC3	n									14 (12, 17)	0 (0, 0)	7 (5, 7)	4 (1, 5)	0 (0, 0)	1 (0, 2)	0 (0, 0)	1 (0, 2)									3 (2, 4)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC3	post_p									0.89 (0.83, 0.93)	NA (NA, NA)	0.73 (0.58, 0.77)	0.55 (0.53, 0.57)	NA (NA, NA)	0.52 (0.5, 0.53)	NA (NA, NA)	0.58 (0.58, 0.58)									0.54 (0.51, 0.83)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC3	r_prob									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
HRD+	TC3	rate									0.054 (0.035, 0.061)	NA (NA, NA)	0.08 (0.016, 0.1)	0.118 (0.091, 0.144)	NA (NA, NA)	0.306 (0.192, 0.419)	NA (NA, NA)	0.346 (0.166, 0.527)									0.06 (0.033, 0.085)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC4	count									2	2	2	2	2	2	2	2									2	2	2	2	2	2	2	2
HRD+	TC4	time									24 (22, 27)	24 (22, 27)	24 (22, 27)	24 (22, 27)	24 (22, 27)	24 (22, 27)	24 (22, 27)	24 (22, 27)									24 (22, 27)	24 (22, 27)	24 (22, 27)	24 (22, 27)	24 (22, 27)	24 (22, 27)	24 (22, 27)	24 (22, 27)
HRD+	TC4	n									13 (11, 15)	0 (0, 0)	7 (5, 9)	6 (4, 8)	0 (0, 0)	2 (1, 4)	0 (0, 0)	1 (0, 2)									2 (0, 4)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC4	post_p									0.82 (0.81, 0.84)	NA (NA, NA)	0.75 (0.56, 0.94)	0.75 (0.67, 0.83)	NA (NA, NA)	0.67 (0.67, 0.67)	NA (NA, NA)	0.54 (0.54, 0.54)									0.63 (0.63, 0.63)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC4	r_prob									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
HRD+	TC4	rate									0.058 (0.055, 0.062)	NA (NA, NA)	0.054 (0.054, 0.054)	0.085 (0.075, 0.095)	NA (NA, NA)	0.021 (0.004, 0.038)	NA (NA, NA)	0.086 (0.086, 0.086)									0.104 (0.104, 0.104)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC1	count					3	3	3	3					3	3	3	3					3	3	3	3					3	3	3	3
TP53+	TC1	time					17 (14, 24)	17 (14, 24)	17 (14, 24)	17 (14, 24)					17 (14, 24)	17 (14, 24)	17 (14, 24)	17 (14, 24)					17 (14, 24)	17 (14, 24)	17 (14, 24)	17 (14, 24)					17 (14, 24)	17 (14, 24)	17 (14, 24)	17 (14, 24)
TP53+	TC1	n					16 (6, 21)	4 (2, 9)	2 (2, 7)	3 (2, 9)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 1)					0 (0, 0)	0 (0, 0)	4 (3, 6)	4 (2, 6)					0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC1	post_p					0.84 (0.63, 0.85)	0.62 (0.55, 0.71)	0.58 (0.55, 0.82)	0.62 (0.56, 0.69)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.66 (0.66, 0.66)					NA (NA, NA)	NA (NA, NA)	0.76 (0.64, 0.79)	0.75 (0.61, 0.76)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC1	r_prob					0.31 (0.31, 0.31)	0.13 (0.13, 0.13)	0.18 (0.18, 0.18)	0.09 (0.09, 0.09)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.12 (0.12, 0.12)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.07 (0.07, 0.07)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC1	rate					0.063 (0.061, 0.094)	0.079 (0.061, 0.094)	0.063 (0.013, 0.089)	0.065 (0.013, 0.095)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)					NA (NA, NA)	NA (NA, NA)	0.052 (0.01, 0.111)	0.05 (0.01, 0.058)					0.216 (0.216, 0.216)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC2	count					6	6	6	6					6	6	6	6					6	6	6	6					6	6	6	6
TP53+	TC2	time					12 (11, 16)	12 (11, 16)	12 (11, 16)	12 (11, 16)					12 (11, 16)	12 (11, 16)	12 (11, 16)	12 (11, 16)					12 (11, 16)	12 (11, 16)	12 (11, 16)	12 (11, 16)					12 (11, 16)	12 (11, 16)	12 (11, 16)	12 (11, 16)
TP53+	TC2	n					4 (2, 8)	3 (2, 6)	2 (2, 3)	4 (2, 5)					0 (0, 0)	0 (0, 2)	0 (0, 0)	0 (0, 2)					0 (0, 1)	0 (0, 0)	9 (8, 10)	2 (2, 4)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC2	post_p					0.69 (0.56, 0.82)	0.7 (0.56, 0.79)	0.56 (0.52, 0.59)	0.64 (0.52, 0.74)					NA (NA, NA)	0.68 (0.68, 0.68)	NA (NA, NA)	0.55 (0.52, 0.59)					NA (NA, NA)	NA (NA, NA)	0.88 (0.74, 0.94)	0.55 (0.52, 0.68)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC2	r_prob					0.17 (0.17, 0.17)	0.07 (0.07, 0.07)	0.41 (0.41, 0.41)	0.16 (0.16, 0.16)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.37 (0.37, 0.37)	0.21 (0.21, 0.21)	0.37 (0.37, 0.37)	0.21 (0.21, 0.21)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC2	rate					0.055 (0.043, 0.098)	0 (0, 0.065)	0.045 (0, 0.333)	0.051 (0.017, 0.154)					NA (NA, NA)	0.091 (0.018, 0.228)	NA (NA, NA)	0 (0, 0)					0.066 (0.066, 0.066)	NA (NA, NA)	0.06 (0.046, 0.07)	0.033 (0, 0.083)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.139 (0.139, 0.139)
TP53+	TC3	count					5	5	5	5					5	5	5	5					5	5	5	5					5	5	5	5
TP53+	TC3	time					15 (11, 18)	15 (11, 18)	15 (11, 18)	15 (11, 18)					15 (11, 18)	15 (11, 18)	15 (11, 18)	15 (11, 18)					15 (11, 18)	15 (11, 18)	15 (11, 18)	15 (11, 18)					15 (11, 18)	15 (11, 18)	15 (11, 18)	15 (11, 18)
TP53+	TC3	n					5 (3, 8)	5 (4, 7)	1 (0, 3)	6 (4, 7)					0 (0, 0)	2 (0, 2)	0 (0, 0)	1 (0, 2)					0 (0, 0)	0 (0, 0)	4 (2, 4)	3 (2, 4)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC3	post_p					0.7 (0.58, 0.72)	0.7 (0.54, 0.7)	0.57 (0.54, 0.72)	0.73 (0.67, 0.78)					NA (NA, NA)	0.54 (0.54, 0.54)	NA (NA, NA)	0.54 (0.53, 0.55)					NA (NA, NA)	NA (NA, NA)	0.74 (0.56, 0.82)	0.61 (0.51, 0.79)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC3	r_prob					0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TP53+	TC3	rate					0.052 (0.02, 0.106)	0.109 (0.079, 0.121)	0 (0, 0)	0.031 (0, 0.085)					NA (NA, NA)	0.109 (0.089, 0.171)	NA (NA, NA)	0 (0, 0.4)					NA (NA, NA)	NA (NA, NA)	0.072 (0.018, 0.088)	0.063 (0.056, 0.138)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC4	count					3	3	3	3					3	3	3	3					3	3	3	3					3	3	3	3
TP53+	TC4	time					17 (15, 22)	17 (15, 22)	17 (15, 22)	17 (15, 22)					17 (15, 22)	17 (15, 22)	17 (15, 22)	17 (15, 22)					17 (15, 22)	17 (15, 22)	17 (15, 22)	17 (15, 22)					17 (15, 22)	17 (15, 22)	17 (15, 22)	17 (15, 22)
TP53+	TC4	n					4 (3, 6)	5 (4, 10)	2 (0, 4)	4 (4, 11)					0 (0, 0)	2 (1, 4)	0 (0, 0)	0 (0, 0)					0 (0, 1)	0 (0, 0)	7 (5, 9)	4 (3, 6)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC4	post_p					0.64 (0.59, 0.81)	0.78 (0.7, 0.8)	0.55 (0.54, 0.56)	0.85 (0.75, 0.89)					NA (NA, NA)	0.56 (0.52, 0.6)	NA (NA, NA)	NA (NA, NA)					NA (NA, NA)	NA (NA, NA)	0.72 (0.58, 0.73)	0.55 (0.54, 0.75)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC4	r_prob					0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TP53+	TC4	rate					0.068 (0.028, 0.086)	0.042 (0.033, 0.053)	0.097 (0.083, 0.111)	0.03 (0.006, 0.073)					NA (NA, NA)	0.15 (0.03, 0.449)	NA (NA, NA)	NA (NA, NA)					0 (0, 0)	NA (NA, NA)	0.077 (0.064, 0.082)	0.09 (0.072, 0.164)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC5	count					6	6	6	6					6	6	6	6					6	6	6	6					6	6	6	6
TP53+	TC5	time					14 (11, 25)	14 (11, 25)	14 (11, 25)	14 (11, 25)					14 (11, 25)	14 (11, 25)	14 (11, 25)	14 (11, 25)					14 (11, 25)	14 (11, 25)	14 (11, 25)	14 (11, 25)					14 (11, 25)	14 (11, 25)	14 (11, 25)	14 (11, 25)
TP53+	TC5	n					6 (4, 10)	10 (5, 12)	2 (0, 3)	4 (4, 8)					0 (0, 0)	0 (0, 3)	0 (0, 0)	1 (0, 2)					0 (0, 0)	0 (0, 0)	3 (2, 8)	5 (4, 13)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC5	post_p					0.78 (0.59, 0.87)	0.74 (0.59, 0.78)	0.59 (0.55, 0.61)	0.56 (0.52, 0.64)					NA (NA, NA)	0.58 (0.58, 0.58)	NA (NA, NA)	0.59 (0.59, 0.59)					NA (NA, NA)	NA (NA, NA)	0.57 (0.52, 0.74)	0.64 (0.59, 0.79)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC5	r_prob					0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0 (0, 0)	0.38 (0.38, 0.38)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC5	rate					0.047 (0, 0.168)	0.086 (0.04, 0.118)	0 (0, 0.084)	0.091 (0.067, 0.191)					NA (NA, NA)	0 (0, 0.124)	NA (NA, NA)	0.062 (0.012, 0.528)					NA (NA, NA)	NA (NA, NA)	0.07 (0.023, 0.117)	0.064 (0.049, 0.147)					0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TEfus+	TC1	count			5	5			5	5			5	5			5	5			5	5			5	5			5	5			5	5
TEfus+	TC1	time			21 (17, 29)	21 (17, 29)			21 (17, 29)	21 (17, 29)			21 (17, 29)	21 (17, 29)			21 (17, 29)	21 (17, 29)			21 (17, 29)	21 (17, 29)			21 (17, 29)	21 (17, 29)			21 (17, 29)	21 (17, 29)			21 (17, 29)	21 (17, 29)
TEfus+	TC1	n			1 (0, 2)	4 (2, 5)			3 (1, 4)	8 (4, 9)			0 (0, 2)	0 (0, 2)			0 (0, 0)	2 (1, 3)			3 (3, 5)	2 (0, 2)			7 (4, 13)	3 (3, 6)			1 (0, 1)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	post_p			0.68 (0.6, 0.78)	0.71 (0.63, 0.85)			0.53 (0.52, 0.63)	0.72 (0.55, 0.73)			0.63 (0.53, 0.73)	0.62 (0.56, 0.68)			NA (NA, NA)	0.64 (0.54, 0.75)			0.62 (0.52, 0.86)	0.55 (0.52, 0.58)			0.78 (0.68, 0.83)	0.65 (0.53, 0.79)			0.52 (0.52, 0.52)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC1	r_prob			0.37 (0.37, 0.37)	0.22 (0.22, 0.22)			0.18 (0.18, 0.18)	0.09 (0.09, 0.09)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.18 (0.18, 0.18)	0.14 (0.14, 0.14)			0.12 (0.12, 0.12)	0.07 (0.07, 0.07)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	rate			0 (0, 0.02)	0.029 (0.004, 0.058)			0.118 (0, 0.513)	0.064 (0.055, 0.072)			0.055 (0.011, 0.1)	0.031 (0.024, 0.037)			NA (NA, NA)	0.104 (0.054, 0.458)			0.058 (0.033, 0.238)	0.094 (0.078, 0.166)			0.074 (0.052, 0.123)	0.06 (0.052, 0.153)			0.094 (0.019, 0.179)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC2	count			2	2			2	2			2	2			2	2			2	2			2	2			2	2			2	2
TEfus+	TC2	time			12 (11, 13)	12 (11, 13)			12 (11, 13)	12 (11, 13)			12 (11, 13)	12 (11, 13)			12 (11, 13)	12 (11, 13)			12 (11, 13)	12 (11, 13)			12 (11, 13)	12 (11, 13)			12 (11, 13)	12 (11, 13)			12 (11, 13)	12 (11, 13)
TEfus+	TC2	n			0 (0, 1)	2 (1, 2)			4 (3, 5)	6 (4, 7)			2 (1, 2)	0 (0, 0)			0 (0, 0)	2 (0, 4)			2 (1, 3)	3 (3, 3)			6 (4, 8)	4 (3, 4)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	post_p			0.55 (0.55, 0.55)	0.54 (0.54, 0.54)			0.6 (0.57, 0.64)	0.75 (0.74, 0.75)			0.55 (0.53, 0.56)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)			0.55 (0.53, 0.58)	0.57 (0.52, 0.62)			0.76 (0.6, 0.91)	0.58 (0.53, 0.64)			NA (NA, NA)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC2	r_prob			0.25 (0.25, 0.25)	0.03 (0.03, 0.03)			0.41 (0.41, 0.41)	0.16 (0.16, 0.16)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.41 (0.41, 0.41)	0.29 (0.29, 0.29)			0.37 (0.37, 0.37)	0.21 (0.21, 0.21)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	rate			0 (0, 0)	0 (0, 0)			0.056 (0.011, 0.101)	0.053 (0.049, 0.057)			0.057 (0.011, 0.102)	NA (NA, NA)			NA (NA, NA)	0.074 (0.074, 0.074)			0.038 (0.008, 0.069)	0.077 (0.048, 0.105)			0.021 (0.004, 0.038)	0.061 (0.055, 0.067)			NA (NA, NA)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC3	count			4	4			4	4			4	4			4	4			4	4			4	4			4	4			4	4
TEfus+	TC3	time			16 (14, 17)	16 (14, 17)			16 (14, 17)	16 (14, 17)			16 (14, 17)	16 (14, 17)			16 (14, 17)	16 (14, 17)			16 (14, 17)	16 (14, 17)			16 (14, 17)	16 (14, 17)			16 (14, 17)	16 (14, 17)			16 (14, 17)	16 (14, 17)
TEfus+	TC3	n			2 (1, 3)	4 (3, 5)			0 (0, 1)	4 (4, 5)			4 (4, 5)	2 (1, 3)			0 (0, 1)	0 (0, 1)			2 (1, 4)	0 (0, 2)			5 (4, 6)	3 (2, 4)			0 (0, 1)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC3	post_p			0.53 (0.51, 0.62)	0.59 (0.55, 0.7)			0.53 (0.53, 0.53)	0.66 (0.6, 0.74)			0.64 (0.53, 0.71)	0.55 (0.52, 0.59)			NA (NA, NA)	NA (NA, NA)			0.59 (0.53, 0.61)	0.53 (0.51, 0.54)			0.62 (0.52, 0.78)	0.6 (0.58, 0.65)			NA (NA, NA)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC3	r_prob			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0 (0, 0)	0 (0, 0)			0.06 (0.06, 0.06)	0.07 (0.07, 0.07)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TEfus+	TC3	rate			0.072 (0, 0.167)	0.055 (0.031, 0.085)			0 (0, 0)	0.066 (0.017, 0.094)			0.068 (0.018, 0.088)	0 (0, 0.082)			0.15 (0.15, 0.15)	0 (0, 0)			0.068 (0, 0.186)	0.1 (0.02, 0.18)			0.101 (0.064, 0.126)	0.104 (0.086, 0.139)			0 (0, 0)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC4	count			1	1			1	1			1	1			1	1			1	1			1	1			1	1			1	1
TEfus+	TC4	time			16 (16, 16)	16 (16, 16)			16 (16, 16)	16 (16, 16)			16 (16, 16)	16 (16, 16)			16 (16, 16)	16 (16, 16)			16 (16, 16)	16 (16, 16)			16 (16, 16)	16 (16, 16)			16 (16, 16)	16 (16, 16)			16 (16, 16)	16 (16, 16)
TEfus+	TC4	n			0 (0, 0)	2 (2, 2)			3 (3, 3)	7 (7, 7)			7 (7, 7)	0 (0, 0)			0 (0, 0)	1 (1, 1)			0 (0, 0)	0 (0, 0)			8 (8, 8)	2 (2, 2)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC4	post_p			NA (NA, NA)	0.5 (0.5, 0.5)			0.57 (0.57, 0.57)	0.74 (0.74, 0.74)			0.93 (0.93, 0.93)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)			0.92 (0.92, 0.92)	0.54 (0.54, 0.54)			NA (NA, NA)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC4	r_prob			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0 (0, 0)	0 (0, 0)			0.06 (0.06, 0.06)	0.07 (0.07, 0.07)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TEfus+	TC4	rate			NA (NA, NA)	0.205 (0.205, 0.205)			0.148 (0.148, 0.148)	0.084 (0.084, 0.084)			0.028 (0.028, 0.028)	NA (NA, NA)			NA (NA, NA)	0 (0, 0)			NA (NA, NA)	NA (NA, NA)			0.048 (0.048, 0.048)	0.119 (0.119, 0.119)			NA (NA, NA)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC5	count			3	3			3	3			3	3			3	3			3	3			3	3			3	3			3	3
TEfus+	TC5	time			13 (11, 13)	13 (11, 13)			13 (11, 13)	13 (11, 13)			13 (11, 13)	13 (11, 13)			13 (11, 13)	13 (11, 13)			13 (11, 13)	13 (11, 13)			13 (11, 13)	13 (11, 13)			13 (11, 13)	13 (11, 13)			13 (11, 13)	13 (11, 13)
TEfus+	TC5	n			0 (0, 2)	3 (2, 3)			1 (0, 2)	5 (5, 10)			1 (0, 3)	1 (0, 2)			0 (0, 0)	0 (0, 0)			1 (1, 2)	4 (2, 4)			2 (2, 4)	5 (5, 7)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC5	post_p			NA (NA, NA)	0.52 (0.51, 0.55)			0.58 (0.57, 0.6)	0.75 (0.59, 0.79)			0.55 (0.55, 0.56)	0.62 (0.62, 0.62)			NA (NA, NA)	NA (NA, NA)			0.55 (0.54, 0.56)	0.58 (0.56, 0.6)			0.55 (0.53, 0.65)	0.73 (0.63, 0.8)			NA (NA, NA)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC5	r_prob			0 (0, 0)	0.38 (0.38, 0.38)			0 (0, 0)	0.38 (0.38, 0.38)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0.29 (0.29, 0.29)			0 (0, 0)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC5	rate			0.059 (0.059, 0.059)	0.083 (0.017, 0.106)			0 (0, 0)	0.095 (0.046, 0.101)			0.058 (0.012, 0.105)	0 (0, 0)			NA (NA, NA)	NA (NA, NA)			0 (0, 0)	0 (0, 0)			0.05 (0.01, 0.084)	0.045 (0.032, 0.094)			NA (NA, NA)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
PI3K+	TC1	count		19		19		19		19		19		19		19		19		19		19		19		19		19		19		19		19
PI3K+	TC1	time		19 (13, 30)		19 (13, 30)		19 (13, 30)		19 (13, 30)		19 (13, 30)		19 (13, 30)		19 (13, 30)		19 (13, 30)		19 (13, 30)		19 (13, 30)		19 (13, 30)		19 (13, 30)		19 (13, 30)		19 (13, 30)		19 (13, 30)		19 (13, 30)
PI3K+	TC1	n		5 (2, 13)		4 (1, 6)		9 (4, 15)		5 (2, 9)		0 (0, 0)		0 (0, 1)		1 (0, 2)		0 (0, 2)		0 (0, 1)		1 (0, 4)		0 (0, 0)		4 (2, 10)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC1	post_p		0.84 (0.7, 0.94)		0.68 (0.54, 0.87)		0.73 (0.59, 0.85)		0.69 (0.53, 0.74)		NA (NA, NA)		0.57 (0.54, 0.62)		0.6 (0.54, 0.64)		0.55 (0.54, 0.57)		0.56 (0.53, 0.61)		0.56 (0.53, 0.68)		NA (NA, NA)		0.67 (0.53, 0.91)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC1	r_prob		0.22 (0.22, 0.22)		0.22 (0.22, 0.22)		0.13 (0.13, 0.13)		0.09 (0.09, 0.09)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.14 (0.14, 0.14)		0.14 (0.14, 0.14)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC1	rate		0.02 (0, 0.041)		0.045 (0.015, 0.095)		0.07 (0.053, 0.098)		0.081 (0.044, 0.12)		NA (NA, NA)		0 (0, 0.058)		0 (0, 0.15)		0.059 (0, 0.558)		0 (0, 0.04)		0.061 (0, 0.195)		0 (0, 0)		0.06 (0, 0.121)		NA (NA, NA)		NA (NA, NA)		0.887 (0.285, 1.489)		NA (NA, NA)
PI3K+	TC2	count		2		2		2		2		2		2		2		2		2		2		2		2		2		2		2		2
PI3K+	TC2	time		14 (12, 16)		14 (12, 16)		14 (12, 16)		14 (12, 16)		14 (12, 16)		14 (12, 16)		14 (12, 16)		14 (12, 16)		14 (12, 16)		14 (12, 16)		14 (12, 16)		14 (12, 16)		14 (12, 16)		14 (12, 16)		14 (12, 16)		14 (12, 16)
PI3K+	TC2	n		6 (4, 7)		2 (0, 4)		5 (5, 5)		9 (9, 9)		0 (0, 0)		2 (2, 2)		0 (0, 1)		0 (0, 0)		1 (1, 1)		1 (1, 1)		0 (0, 0)		4 (3, 4)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC2	post_p		0.62 (0.54, 0.69)		0.84 (0.84, 0.84)		0.53 (0.52, 0.54)		0.86 (0.82, 0.9)		NA (NA, NA)		0.52 (0.52, 0.52)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		0.55 (0.52, 0.57)		NA (NA, NA)		0.62 (0.57, 0.67)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC2	r_prob		0.03 (0.03, 0.03)		0.03 (0.03, 0.03)		0.07 (0.07, 0.07)		0.16 (0.16, 0.16)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0.21 (0.21, 0.21)		0.21 (0.21, 0.21)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC2	rate		0.089 (0.061, 0.118)		0 (0, 0)		0.136 (0.118, 0.153)		0.017 (0.016, 0.018)		NA (NA, NA)		0.157 (0.031, 0.283)		0 (0, 0)		NA (NA, NA)		1.234 (0.247, 2.222)		0 (0, 0)		NA (NA, NA)		0.038 (0.008, 0.068)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC3	count		2		2		2		2		2		2		2		2		2		2		2		2		2		2		2		2
PI3K+	TC3	time		16 (14, 18)		16 (14, 18)		16 (14, 18)		16 (14, 18)		16 (14, 18)		16 (14, 18)		16 (14, 18)		16 (14, 18)		16 (14, 18)		16 (14, 18)		16 (14, 18)		16 (14, 18)		16 (14, 18)		16 (14, 18)		16 (14, 18)		16 (14, 18)
PI3K+	TC3	n		4 (4, 4)		3 (3, 3)		7 (5, 9)		5 (5, 5)		0 (0, 0)		0 (0, 1)		2 (1, 2)		2 (0, 3)		0 (0, 1)		1 (1, 1)		0 (0, 0)		4 (2, 5)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC3	post_p		0.69 (0.65, 0.72)		0.51 (0.51, 0.52)		0.72 (0.7, 0.73)		0.76 (0.68, 0.84)		NA (NA, NA)		0.54 (0.54, 0.54)		0.54 (0.54, 0.54)		NA (NA, NA)		NA (NA, NA)		0.56 (0.56, 0.56)		NA (NA, NA)		0.54 (0.53, 0.55)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC3	r_prob		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC3	rate		0.057 (0.055, 0.058)		0.085 (0.078, 0.093)		0.086 (0.082, 0.09)		0.054 (0.036, 0.072)		NA (NA, NA)		0 (0, 0)		0.392 (0.127, 0.658)		0.044 (0.044, 0.044)		0.31 (0.31, 0.31)		0 (0, 0)		NA (NA, NA)		0.064 (0.047, 0.081)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC4	count		1		1		1		1		1		1		1		1		1		1		1		1		1		1		1		1
PI3K+	TC4	time		20 (20, 20)		20 (20, 20)		20 (20, 20)		20 (20, 20)		20 (20, 20)		20 (20, 20)		20 (20, 20)		20 (20, 20)		20 (20, 20)		20 (20, 20)		20 (20, 20)		20 (20, 20)		20 (20, 20)		20 (20, 20)		20 (20, 20)		20 (20, 20)
PI3K+	TC4	n		5 (5, 5)		5 (5, 5)		4 (4, 4)		4 (4, 4)		0 (0, 0)		1 (1, 1)		0 (0, 0)		1 (1, 1)		0 (0, 0)		3 (3, 3)		0 (0, 0)		5 (5, 5)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC4	post_p		0.57 (0.57, 0.57)		0.83 (0.83, 0.83)		0.54 (0.54, 0.54)		0.88 (0.88, 0.88)		NA (NA, NA)		0.59 (0.59, 0.59)		NA (NA, NA)		0.65 (0.65, 0.65)		NA (NA, NA)		0.9 (0.9, 0.9)		NA (NA, NA)		0.73 (0.73, 0.73)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC4	r_prob		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC4	rate		0.069 (0.069, 0.069)		0.027 (0.027, 0.027)		0.066 (0.066, 0.066)		0 (0, 0)		NA (NA, NA)		0 (0, 0)		NA (NA, NA)		0.061 (0.061, 0.061)		NA (NA, NA)		0 (0, 0)		NA (NA, NA)		0.041 (0.041, 0.041)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)

Futility:

signature	treatment	var	—–	—-+	—+-	—++	–+–	–+-+	–++-	–+++	-+—	-+–+	-+-+-	-+-++	-++–	-++-+	-+++-	-++++	+—-	+—+	+–+-	+–++	+-+–	+-+-+	+-++-	+-+++	++—	++–+	++-+-	++-++	+++–	+++-+	++++-	+++++
all	TC1	count	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
all	TC1	time	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)
all	TC1	n	15 (15, 15)	3 (3, 3)	0 (0, 0)	1 (1, 1)	6 (6, 6)	3 (3, 3)	0 (0, 0)	0 (0, 0)	1 (1, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	1 (1, 1)	0 (0, 0)	0 (0, 0)	1 (1, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC1	post_p	0.43 (0.43, 0.43)	0.48 (0.48, 0.48)	NA (NA, NA)	NA (NA, NA)	0.41 (0.41, 0.41)	0.39 (0.39, 0.39)	NA (NA, NA)	NA (NA, NA)	0.46 (0.46, 0.46)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.5 (0.5, 0.5)	NA (NA, NA)	NA (NA, NA)	0.46 (0.46, 0.46)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC1	r_prob	0.41 (0.41, 0.41)	0.22 (0.22, 0.22)	0.37 (0.37, 0.37)	0.22 (0.22, 0.22)	0.31 (0.31, 0.31)	0.13 (0.13, 0.13)	0.18 (0.18, 0.18)	0.09 (0.09, 0.09)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.14 (0.14, 0.14)	0.18 (0.18, 0.18)	0.14 (0.14, 0.14)	0.12 (0.12, 0.12)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC1	rate	0.144 (0.144, 0.144)	0.08 (0.08, 0.08)	NA (NA, NA)	0 (0, 0)	0.11 (0.11, 0.11)	0.313 (0.313, 0.313)	NA (NA, NA)	NA (NA, NA)	1.763 (1.763, 1.763)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	0.633 (0.633, 0.633)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC2	count	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7
all	TC2	time	10 (5, 31)	10 (5, 31)	10 (5, 31)	10 (5, 31)	10 (5, 31)	10 (5, 31)	10 (5, 31)	10 (5, 31)	10 (5, 31)	10 (5, 31)	10 (5, 31)	10 (5, 31)	10 (5, 31)	10 (5, 31)	10 (5, 31)	10 (5, 31)	10 (5, 31)	10 (5, 31)	10 (5, 31)	10 (5, 31)	10 (5, 31)	10 (5, 31)	10 (5, 31)	10 (5, 31)	10 (5, 31)	10 (5, 31)	10 (5, 31)	10 (5, 31)	10 (5, 31)	10 (5, 31)	10 (5, 31)	10 (5, 31)
all	TC2	n	9 (8, 24)	3 (1, 6)	0 (0, 1)	1 (0, 6)	3 (2, 8)	3 (0, 4)	1 (1, 4)	4 (2, 7)	2 (0, 6)	0 (0, 0)	1 (0, 2)	0 (0, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 1)	2 (1, 3)	0 (0, 1)	2 (1, 4)	1 (0, 3)	0 (0, 1)	0 (0, 0)	6 (2, 12)	3 (1, 6)	1 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC2	post_p	0.38 (0.06, 0.42)	0.38 (0.18, 0.41)	0.48 (0.47, 0.49)	0.4 (0.35, 0.46)	0.42 (0.19, 0.47)	0.4 (0.37, 0.42)	0.42 (0.2, 0.46)	0.28 (0.17, 0.42)	0.38 (0.23, 0.47)	NA (NA, NA)	0.3 (0.17, 0.46)	0.36 (0.3, 0.42)	NA (NA, NA)	0.44 (0.44, 0.44)	NA (NA, NA)	NA (NA, NA)	0.48 (0.24, 0.49)	0.45 (0.45, 0.45)	0.48 (0.29, 0.49)	0.47 (0.35, 0.47)	0.43 (0.42, 0.43)	NA (NA, NA)	0.33 (0.24, 0.39)	0.38 (0.19, 0.42)	0.4 (0.38, 0.46)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC2	r_prob	0.18 (0.18, 0.18)	0.03 (0.03, 0.03)	0.25 (0.25, 0.25)	0.03 (0.03, 0.03)	0.17 (0.17, 0.17)	0.07 (0.07, 0.07)	0.41 (0.41, 0.41)	0.16 (0.16, 0.16)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.29 (0.29, 0.29)	0.41 (0.41, 0.41)	0.29 (0.29, 0.29)	0.37 (0.37, 0.37)	0.21 (0.21, 0.21)	0.37 (0.37, 0.37)	0.21 (0.21, 0.21)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC2	rate	0.121 (0.082, 0.144)	0.182 (0.11, 4.167)	0 (0, 0.04)	0.094 (0.083, 0.555)	0.212 (0.075, 0.329)	0.17 (0.15, 0.381)	0.266 (0.076, 3.177)	0.162 (0.138, 0.251)	0.175 (0.118, 2.032)	NA (NA, NA)	0.258 (0.132, 0.551)	0.214 (0.17, 0.417)	NA (NA, NA)	0.2 (0.2, 0.2)	NA (NA, NA)	0.368 (0.148, 0.622)	0.14 (0.097, 0.524)	0.474 (0.189, 0.828)	0.171 (0.052, 0.275)	0.122 (0, 0.337)	0.239 (0.112, 0.28)	NA (NA, NA)	0.166 (0.124, 0.717)	0.174 (0.072, 0.586)	0.394 (0.225, 0.559)	NA (NA, NA)	0.092 (0.018, 0.166)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC3	count	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3
all	TC3	time	16 (10, 19)	16 (10, 19)	16 (10, 19)	16 (10, 19)	16 (10, 19)	16 (10, 19)	16 (10, 19)	16 (10, 19)	16 (10, 19)	16 (10, 19)	16 (10, 19)	16 (10, 19)	16 (10, 19)	16 (10, 19)	16 (10, 19)	16 (10, 19)	16 (10, 19)	16 (10, 19)	16 (10, 19)	16 (10, 19)	16 (10, 19)	16 (10, 19)	16 (10, 19)	16 (10, 19)	16 (10, 19)	16 (10, 19)	16 (10, 19)	16 (10, 19)	16 (10, 19)	16 (10, 19)	16 (10, 19)	16 (10, 19)
all	TC3	n	15 (8, 15)	5 (2, 8)	0 (0, 0)	1 (0, 3)	5 (3, 7)	3 (3, 6)	2 (0, 4)	1 (0, 5)	2 (1, 4)	0 (0, 0)	4 (2, 6)	0 (0, 2)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 2)	1 (1, 1)	2 (1, 4)	0 (0, 2)	0 (0, 1)	0 (0, 0)	4 (2, 5)	1 (1, 7)	3 (1, 4)	0 (0, 0)	0 (0, 1)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC3	post_p	0.4 (0.24, 0.44)	0.35 (0.29, 0.39)	NA (NA, NA)	0.47 (0.45, 0.48)	0.41 (0.34, 0.41)	0.35 (0.33, 0.36)	0.36 (0.33, 0.39)	0.24 (0.17, 0.3)	0.36 (0.26, 0.38)	NA (NA, NA)	0.34 (0.22, 0.36)	0.44 (0.44, 0.44)	NA (NA, NA)	0.39 (0.39, 0.39)	NA (NA, NA)	NA (NA, NA)	0.17 (0.17, 0.17)	0.42 (0.41, 0.44)	0.47 (0.4, 0.48)	0.46 (0.46, 0.46)	NA (NA, NA)	NA (NA, NA)	0.39 (0.24, 0.46)	0.38 (0.38, 0.39)	0.41 (0.19, 0.47)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC3	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
all	TC3	rate	0.099 (0.086, 0.125)	0.197 (0.111, 0.542)	NA (NA, NA)	0.038 (0.008, 0.068)	0.221 (0.14, 0.233)	0.213 (0.16, 0.339)	0.194 (0.122, 0.267)	0.846 (0.295, 1.398)	0.284 (0.27, 3.672)	NA (NA, NA)	0.164 (0.129, 0.18)	0.121 (0.121, 0.121)	NA (NA, NA)	0.115 (0.115, 0.115)	NA (NA, NA)	NA (NA, NA)	0.511 (0.511, 0.511)	0.362 (0.279, 1.603)	0.118 (0.024, 0.323)	0.361 (0.361, 0.361)	0 (0, 0)	NA (NA, NA)	0.259 (0.146, 0.362)	0.446 (0.159, 4.557)	0.263 (0.166, 0.696)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC4	count	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5
all	TC4	time	19 (8, 24)	19 (8, 24)	19 (8, 24)	19 (8, 24)	19 (8, 24)	19 (8, 24)	19 (8, 24)	19 (8, 24)	19 (8, 24)	19 (8, 24)	19 (8, 24)	19 (8, 24)	19 (8, 24)	19 (8, 24)	19 (8, 24)	19 (8, 24)	19 (8, 24)	19 (8, 24)	19 (8, 24)	19 (8, 24)	19 (8, 24)	19 (8, 24)	19 (8, 24)	19 (8, 24)	19 (8, 24)	19 (8, 24)	19 (8, 24)	19 (8, 24)	19 (8, 24)	19 (8, 24)	19 (8, 24)	19 (8, 24)
all	TC4	n	8 (5, 22)	3 (1, 7)	1 (0, 2)	2 (0, 4)	3 (1, 4)	3 (2, 5)	1 (0, 3)	1 (0, 4)	6 (4, 6)	0 (0, 0)	4 (1, 6)	0 (0, 1)	0 (0, 0)	1 (0, 2)	0 (0, 0)	0 (0, 3)	1 (1, 3)	0 (0, 0)	2 (0, 3)	0 (0, 0)	0 (0, 0)	0 (0, 0)	2 (1, 5)	4 (2, 6)	1 (0, 3)	0 (0, 0)	1 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC4	post_p	0.34 (0.22, 0.45)	0.38 (0.13, 0.47)	0.34 (0.34, 0.34)	0.27 (0.16, 0.34)	0.38 (0.31, 0.47)	0.45 (0.37, 0.46)	0.42 (0.42, 0.42)	0.23 (0.23, 0.4)	0.35 (0.16, 0.44)	NA (NA, NA)	0.41 (0.4, 0.43)	0.46 (0.43, 0.48)	NA (NA, NA)	0.4 (0.37, 0.45)	NA (NA, NA)	NA (NA, NA)	0.41 (0.39, 0.43)	NA (NA, NA)	0.39 (0.27, 0.47)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.44 (0.3, 0.48)	0.44 (0.32, 0.45)	0.33 (0.25, 0.4)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC4	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
all	TC4	rate	0.111 (0.088, 0.16)	0.358 (0.128, 1.568)	0.223 (0.192, 0.308)	0.245 (0.219, 0.364)	0.164 (0.132, 0.294)	0.128 (0.096, 0.194)	0.209 (0.042, 0.626)	0.21 (0.142, 0.319)	0.17 (0.136, 0.216)	NA (NA, NA)	0.161 (0.115, 0.581)	0.302 (0.06, 0.543)	NA (NA, NA)	0.19 (0.168, 0.795)	NA (NA, NA)	0.119 (0.024, 0.213)	0.272 (0.034, 1.072)	NA (NA, NA)	0.26 (0.183, 0.646)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.22 (0.133, 0.378)	0.15 (0.115, 0.256)	1.24 (0.449, 1.517)	NA (NA, NA)	0.124 (0.027, 0.219)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC5	count	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
all	TC5	time	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)
all	TC5	n	8 (8, 8)	9 (9, 9)	2 (2, 2)	4 (4, 4)	7 (7, 7)	5 (5, 5)	0 (0, 0)	4 (4, 4)	2 (2, 2)	0 (0, 0)	0 (0, 0)	1 (1, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	2 (2, 2)	1 (1, 1)	0 (0, 0)	0 (0, 0)	1 (1, 1)	5 (5, 5)	1 (1, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC5	post_p	0.22 (0.22, 0.22)	0.14 (0.14, 0.14)	0.5 (0.5, 0.5)	0.3 (0.3, 0.3)	0.46 (0.46, 0.46)	0.34 (0.34, 0.34)	NA (NA, NA)	0.28 (0.28, 0.28)	0.43 (0.43, 0.43)	NA (NA, NA)	NA (NA, NA)	0.44 (0.44, 0.44)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.5 (0.5, 0.5)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.41 (0.41, 0.41)	0.44 (0.44, 0.44)	0.47 (0.47, 0.47)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC5	r_prob	0 (0, 0)	0.38 (0.38, 0.38)	0 (0, 0)	0.38 (0.38, 0.38)	0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0 (0, 0)	0.38 (0.38, 0.38)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC5	rate	0.175 (0.175, 0.175)	0.207 (0.207, 0.207)	0.173 (0.173, 0.173)	0.259 (0.259, 0.259)	0.148 (0.148, 0.148)	0.113 (0.113, 0.113)	NA (NA, NA)	0.184 (0.184, 0.184)	0.192 (0.192, 0.192)	NA (NA, NA)	NA (NA, NA)	0.304 (0.304, 0.304)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0.134 (0.134, 0.134)	NA (NA, NA)	NA (NA, NA)	0.337 (0.337, 0.337)	0.094 (0.094, 0.094)	0.338 (0.338, 0.338)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
AR- & TP53-	TC1	count	1	1	1	1					1	1	1	1
AR- & TP53-	TC1	time	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)					4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)
AR- & TP53-	TC1	n	24 (24, 24)	2 (2, 2)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC1	post_p	0.38 (0.38, 0.38)	0.4 (0.4, 0.4)	NA (NA, NA)	NA (NA, NA)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
AR- & TP53-	TC1	r_prob	0.41 (0.41, 0.41)	0.22 (0.22, 0.22)	0.37 (0.37, 0.37)	0.22 (0.22, 0.22)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC1	rate	0.093 (0.093, 0.093)	0.51 (0.51, 0.51)	NA (NA, NA)	NA (NA, NA)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
AR- & TP53-	TC2	count	235	235	235	235					235	235	235	235
AR- & TP53-	TC2	time	23 (13, 34)	23 (13, 34)	23 (13, 34)	23 (13, 34)					23 (13, 34)	23 (13, 34)	23 (13, 34)	23 (13, 34)
AR- & TP53-	TC2	n	17 (9, 53)	7 (3, 19)	2 (0, 5)	4 (1, 10)					6 (3, 17)	0 (0, 0)	3 (1, 8)	1 (0, 4)
AR- & TP53-	TC2	post_p	0.1 (0.01, 0.39)	0.3 (0.11, 0.46)	0.41 (0.27, 0.49)	0.41 (0.21, 0.48)					0.35 (0.13, 0.48)	NA (NA, NA)	0.37 (0.19, 0.48)	0.42 (0.3, 0.48)
AR- & TP53-	TC2	r_prob	0.18 (0.18, 0.18)	0.03 (0.03, 0.03)	0.25 (0.25, 0.25)	0.03 (0.03, 0.03)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC2	rate	0.122 (0.093, 0.191)	0.137 (0.09, 0.299)	0.168 (0.066, 0.476)	0.138 (0.08, 0.411)					0.14 (0.091, 0.319)	0.108 (0, 0.721)	0.163 (0.093, 0.451)	0.18 (0.066, 0.622)
AR- & TP53-	TC3	count	243	243	243	243					243	243	243	243
AR- & TP53-	TC3	time	22 (12, 32)	22 (12, 32)	22 (12, 32)	22 (12, 32)					22 (12, 32)	22 (12, 32)	22 (12, 32)	22 (12, 32)
AR- & TP53-	TC3	n	16 (8, 62)	6 (2, 16)	2 (0, 4)	3 (1, 8)					7 (4, 17)	0 (0, 0)	4 (1, 9)	2 (0, 4)
AR- & TP53-	TC3	post_p	0.17 (0.03, 0.42)	0.32 (0.12, 0.47)	0.43 (0.29, 0.49)	0.39 (0.21, 0.48)					0.33 (0.13, 0.47)	0.45 (0.45, 0.45)	0.38 (0.22, 0.48)	0.42 (0.32, 0.49)
AR- & TP53-	TC3	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
AR- & TP53-	TC3	rate	0.118 (0.088, 0.19)	0.137 (0.09, 0.288)	0.173 (0.067, 0.502)	0.161 (0.087, 0.653)					0.129 (0.086, 0.234)	0.374 (0, 2.184)	0.146 (0.084, 0.461)	0.172 (0.07, 0.496)
AR- & TP53-	TC4	count	218	218	218	218					218	218	218	218
AR- & TP53-	TC4	time	22 (13, 34)	22 (13, 34)	22 (13, 34)	22 (13, 34)					22 (13, 34)	22 (13, 34)	22 (13, 34)	22 (13, 34)
AR- & TP53-	TC4	n	17 (7, 59)	6 (2, 18)	1 (0, 3)	3 (1, 9)					7 (4, 17)	0 (0, 0)	4 (2, 8)	2 (0, 5)
AR- & TP53-	TC4	post_p	0.18 (0.03, 0.46)	0.32 (0.11, 0.46)	0.41 (0.31, 0.48)	0.4 (0.24, 0.49)					0.35 (0.15, 0.47)	NA (NA, NA)	0.36 (0.2, 0.47)	0.42 (0.31, 0.49)
AR- & TP53-	TC4	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
AR- & TP53-	TC4	rate	0.116 (0.087, 0.195)	0.136 (0.089, 0.366)	0.214 (0.055, 0.951)	0.143 (0.081, 0.429)					0.125 (0.086, 0.238)	0.44 (0, 4.478)	0.151 (0.084, 0.464)	0.153 (0.078, 0.599)
AR- & TP53-	TC5	count	241	241	241	241					241	241	241	241
AR- & TP53-	TC5	time	21 (12, 31)	21 (12, 31)	21 (12, 31)	21 (12, 31)					21 (12, 31)	21 (12, 31)	21 (12, 31)	21 (12, 31)
AR- & TP53-	TC5	n	16 (7, 55)	8 (5, 18)	1 (0, 4)	4 (2, 8)					6 (2, 15)	0 (0, 0)	3 (1, 7)	1 (0, 4)
AR- & TP53-	TC5	post_p	0.19 (0.03, 0.43)	0.29 (0.1, 0.46)	0.43 (0.28, 0.49)	0.35 (0.17, 0.47)					0.36 (0.15, 0.48)	NA (NA, NA)	0.41 (0.21, 0.49)	0.43 (0.33, 0.49)
AR- & TP53-	TC5	r_prob	0 (0, 0)	0.38 (0.38, 0.38)	0 (0, 0)	0.38 (0.38, 0.38)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC5	rate	0.118 (0.087, 0.2)	0.121 (0.087, 0.221)	0.161 (0.034, 0.537)	0.144 (0.084, 0.387)					0.132 (0.09, 0.352)	0.066 (0, 0.19)	0.162 (0.089, 0.581)	0.154 (0.051, 0.667)
HRD+	TC2	count									47	47	47	47	47	47	47	47									47	47	47	47	47	47	47	47
HRD+	TC2	time									32 (23, 35)	32 (23, 35)	32 (23, 35)	32 (23, 35)	32 (23, 35)	32 (23, 35)	32 (23, 35)	32 (23, 35)									32 (23, 35)	32 (23, 35)	32 (23, 35)	32 (23, 35)	32 (23, 35)	32 (23, 35)	32 (23, 35)	32 (23, 35)
HRD+	TC2	n									14 (7, 22)	0 (0, 0)	6 (2, 13)	3 (1, 6)	0 (0, 0)	1 (0, 3)	0 (0, 0)	1 (0, 3)									3 (1, 5)	0 (0, 0)	1 (0, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC2	post_p									0.29 (0.12, 0.46)	NA (NA, NA)	0.39 (0.14, 0.47)	0.42 (0.26, 0.48)	NA (NA, NA)	0.39 (0.32, 0.47)	NA (NA, NA)	0.43 (0.28, 0.48)									0.38 (0.23, 0.49)	NA (NA, NA)	0.42 (0.4, 0.48)	NA (NA, NA)	0.46 (0.46, 0.46)	NA (NA, NA)	0.46 (0.46, 0.46)	NA (NA, NA)
HRD+	TC2	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC2	rate									0.114 (0.097, 0.186)	NA (NA, NA)	0.132 (0.09, 0.333)	0.179 (0.086, 0.503)	0.025 (0.005, 0.045)	0.264 (0.088, 0.815)	NA (NA, NA)	0.194 (0.072, 0.74)									0.19 (0.101, 0.444)	NA (NA, NA)	0.157 (0, 0.706)	NA (NA, NA)	0.355 (0.182, 0.93)	NA (NA, NA)	0.301 (0.198, 0.405)	0 (0, 0)
HRD+	TC3	count									66	66	66	66	66	66	66	66									66	66	66	66	66	66	66	66
HRD+	TC3	time									27 (20, 34)	27 (20, 34)	27 (20, 34)	27 (20, 34)	27 (20, 34)	27 (20, 34)	27 (20, 34)	27 (20, 34)									27 (20, 34)	27 (20, 34)	27 (20, 34)	27 (20, 34)	27 (20, 34)	27 (20, 34)	27 (20, 34)	27 (20, 34)
HRD+	TC3	n									11 (6, 22)	0 (0, 0)	5 (3, 10)	2 (0, 5)	0 (0, 0)	1 (0, 3)	0 (0, 0)	1 (0, 3)									4 (2, 7)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC3	post_p									0.36 (0.14, 0.47)	0.5 (0.5, 0.5)	0.34 (0.13, 0.47)	0.4 (0.28, 0.48)	0.5 (0.5, 0.5)	0.45 (0.38, 0.49)	NA (NA, NA)	0.43 (0.31, 0.48)									0.38 (0.21, 0.48)	NA (NA, NA)	0.46 (0.43, 0.48)	NA (NA, NA)	0.48 (0.43, 0.49)	0.48 (0.48, 0.48)	0.46 (0.46, 0.46)	NA (NA, NA)
HRD+	TC3	r_prob									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
HRD+	TC3	rate									0.113 (0.088, 0.168)	0.262 (0.068, 0.491)	0.135 (0.09, 0.353)	0.173 (0.092, 0.441)	0.441 (0.149, 0.732)	0.168 (0.081, 0.566)	0.104 (0.021, 3.235)	0.184 (0.076, 0.416)									0.157 (0.103, 0.411)	0.143 (0.072, 0.215)	0.107 (0.006, 2.756)	0.077 (0.015, 0.233)	0.212 (0, 1.51)	0.36 (0.035, 1.603)	2.084 (0.642, 3.527)	0.266 (0.184, 0.348)
HRD+	TC4	count									55	55	55	55	55	55	55	55									55	55	55	55	55	55	55	55
HRD+	TC4	time									28 (21, 34)	28 (21, 34)	28 (21, 34)	28 (21, 34)	28 (21, 34)	28 (21, 34)	28 (21, 34)	28 (21, 34)									28 (21, 34)	28 (21, 34)	28 (21, 34)	28 (21, 34)	28 (21, 34)	28 (21, 34)	28 (21, 34)	28 (21, 34)
HRD+	TC4	n									13 (6, 22)	0 (0, 0)	4 (2, 10)	3 (1, 5)	0 (0, 0)	2 (0, 4)	0 (0, 0)	2 (0, 4)									3 (1, 7)	0 (0, 0)	0 (0, 2)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC4	post_p									0.3 (0.09, 0.46)	0.48 (0.48, 0.48)	0.33 (0.2, 0.49)	0.41 (0.28, 0.49)	NA (NA, NA)	0.42 (0.26, 0.46)	NA (NA, NA)	0.44 (0.35, 0.48)									0.37 (0.21, 0.47)	NA (NA, NA)	0.44 (0.34, 0.47)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC4	r_prob									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
HRD+	TC4	rate									0.118 (0.086, 0.181)	0.122 (0.024, 0.26)	0.143 (0.089, 0.293)	0.173 (0.078, 0.364)	0.192 (0.173, 0.211)	0.195 (0.073, 0.568)	0 (0, 0)	0.184 (0.096, 0.385)									0.156 (0.101, 0.498)	0.121 (0.086, 0.156)	0.165 (0.027, 0.753)	NA (NA, NA)	0.111 (0, 0.774)	0.245 (0.236, 0.255)	NA (NA, NA)	NA (NA, NA)
HRD+	TC5	count									29	29	29	29	29	29	29	29									29	29	29	29	29	29	29	29
HRD+	TC5	time									30 (23, 36)	30 (23, 36)	30 (23, 36)	30 (23, 36)	30 (23, 36)	30 (23, 36)	30 (23, 36)	30 (23, 36)									30 (23, 36)	30 (23, 36)	30 (23, 36)	30 (23, 36)	30 (23, 36)	30 (23, 36)	30 (23, 36)	30 (23, 36)
HRD+	TC5	n									14 (10, 25)	0 (0, 0)	5 (2, 11)	2 (0, 5)	0 (0, 0)	1 (0, 3)	0 (0, 0)	1 (0, 3)									3 (1, 5)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC5	post_p									0.37 (0.12, 0.46)	NA (NA, NA)	0.37 (0.24, 0.48)	0.4 (0.32, 0.48)	0.44 (0.44, 0.44)	0.43 (0.29, 0.49)	NA (NA, NA)	0.41 (0.34, 0.49)									0.42 (0.28, 0.48)	NA (NA, NA)	0.48 (0.45, 0.49)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC5	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC5	rate									0.111 (0.079, 0.141)	0.131 (0.026, 0.22)	0.133 (0.096, 0.292)	0.19 (0.09, 0.467)	0.253 (0.15, 0.355)	0.326 (0.088, 1.119)	0.61 (0.61, 0.61)	0.175 (0.096, 0.689)									0.176 (0.1, 0.554)	0.047 (0.047, 0.047)	0.176 (0.093, 0.9)	0.222 (0.141, 0.303)	0 (0, 0.065)	0.051 (0.051, 0.051)	0.342 (0.342, 0.342)	0.458 (0.458, 0.458)
TP53+	TC1	count					34	34	34	34					34	34	34	34					34	34	34	34					34	34	34	34
TP53+	TC1	time					18 (12, 29)	18 (12, 29)	18 (12, 29)	18 (12, 29)					18 (12, 29)	18 (12, 29)	18 (12, 29)	18 (12, 29)					18 (12, 29)	18 (12, 29)	18 (12, 29)	18 (12, 29)					18 (12, 29)	18 (12, 29)	18 (12, 29)	18 (12, 29)
TP53+	TC1	n					6 (3, 10)	6 (3, 14)	2 (0, 5)	4 (2, 8)					0 (0, 0)	0 (0, 2)	0 (0, 0)	1 (0, 3)					0 (0, 2)	0 (0, 0)	4 (2, 8)	3 (1, 7)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC1	post_p					0.3 (0.2, 0.44)	0.37 (0.22, 0.46)	0.39 (0.29, 0.47)	0.38 (0.21, 0.46)					NA (NA, NA)	0.41 (0.33, 0.46)	NA (NA, NA)	0.43 (0.38, 0.49)					0.48 (0.47, 0.49)	NA (NA, NA)	0.29 (0.11, 0.48)	0.39 (0.2, 0.48)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC1	r_prob					0.31 (0.31, 0.31)	0.13 (0.13, 0.13)	0.18 (0.18, 0.18)	0.09 (0.09, 0.09)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.12 (0.12, 0.12)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.07 (0.07, 0.07)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC1	rate					0.154 (0.104, 0.289)	0.141 (0.11, 0.312)	0.178 (0.113, 0.372)	0.162 (0.101, 0.338)					NA (NA, NA)	0.161 (0.013, 0.381)	NA (NA, NA)	0.173 (0.055, 0.726)					0.132 (0, 2.457)	NA (NA, NA)	0.204 (0.11, 0.629)	0.165 (0.111, 0.647)					0 (0, 0.929)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC2	count					43	43	43	43					43	43	43	43					43	43	43	43					43	43	43	43
TP53+	TC2	time					19 (15, 29)	19 (15, 29)	19 (15, 29)	19 (15, 29)					19 (15, 29)	19 (15, 29)	19 (15, 29)	19 (15, 29)					19 (15, 29)	19 (15, 29)	19 (15, 29)	19 (15, 29)					19 (15, 29)	19 (15, 29)	19 (15, 29)	19 (15, 29)
TP53+	TC2	n					5 (2, 13)	5 (2, 10)	3 (1, 4)	6 (2, 11)					0 (0, 0)	0 (0, 2)	0 (0, 0)	0 (0, 2)					0 (0, 2)	0 (0, 0)	7 (4, 11)	4 (1, 9)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC2	post_p					0.34 (0.18, 0.49)	0.36 (0.22, 0.48)	0.4 (0.24, 0.48)	0.4 (0.24, 0.47)					NA (NA, NA)	0.43 (0.28, 0.48)	NA (NA, NA)	0.43 (0.37, 0.49)					0.44 (0.4, 0.48)	NA (NA, NA)	0.35 (0.18, 0.45)	0.37 (0.21, 0.48)					NA (NA, NA)	NA (NA, NA)	0.46 (0.46, 0.46)	NA (NA, NA)
TP53+	TC2	r_prob					0.17 (0.17, 0.17)	0.07 (0.07, 0.07)	0.41 (0.41, 0.41)	0.16 (0.16, 0.16)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.37 (0.37, 0.37)	0.21 (0.21, 0.21)	0.37 (0.37, 0.37)	0.21 (0.21, 0.21)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC2	rate					0.168 (0.104, 0.302)	0.158 (0.116, 0.499)	0.182 (0.104, 0.6)	0.152 (0.112, 0.281)					NA (NA, NA)	0.206 (0.044, 0.616)	0.107 (0.021, 0.193)	0.203 (0.063, 0.805)					0.182 (0, 0.632)	0 (0, 0)	0.16 (0.098, 0.267)	0.178 (0.092, 0.49)					0.317 (0.051, 0.647)	NA (NA, NA)	0.538 (0.452, 0.623)	NA (NA, NA)
TP53+	TC3	count					26	26	26	26					26	26	26	26					26	26	26	26					26	26	26	26
TP53+	TC3	time					24 (19, 31)	24 (19, 31)	24 (19, 31)	24 (19, 31)					24 (19, 31)	24 (19, 31)	24 (19, 31)	24 (19, 31)					24 (19, 31)	24 (19, 31)	24 (19, 31)	24 (19, 31)					24 (19, 31)	24 (19, 31)	24 (19, 31)	24 (19, 31)
TP53+	TC3	n					5 (2, 8)	5 (3, 12)	2 (0, 6)	5 (2, 10)					0 (0, 0)	1 (0, 2)	0 (0, 0)	1 (0, 2)					0 (0, 1)	0 (0, 0)	5 (1, 13)	4 (2, 10)					0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC3	post_p					0.35 (0.13, 0.48)	0.34 (0.16, 0.47)	0.42 (0.35, 0.47)	0.35 (0.17, 0.46)					NA (NA, NA)	0.44 (0.36, 0.5)	NA (NA, NA)	0.45 (0.31, 0.49)					0.47 (0.45, 0.49)	NA (NA, NA)	0.32 (0.18, 0.48)	0.35 (0.21, 0.44)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC3	r_prob					0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TP53+	TC3	rate					0.176 (0.115, 0.448)	0.159 (0.107, 0.436)	0.181 (0.094, 0.485)	0.178 (0.104, 0.572)					1.329 (0.339, 2.32)	0.224 (0, 3.713)	0.093 (0.093, 0.093)	0.115 (0.072, 0.344)					0.069 (0, 0.731)	1.47 (1.47, 1.47)	0.168 (0.112, 0.394)	0.163 (0.085, 0.353)					0.184 (0.03, 1.337)	172.827 (172.827, 172.827)	NA (NA, NA)	NA (NA, NA)
TP53+	TC4	count					24	24	24	24					24	24	24	24					24	24	24	24					24	24	24	24
TP53+	TC4	time					22 (17, 30)	22 (17, 30)	22 (17, 30)	22 (17, 30)					22 (17, 30)	22 (17, 30)	22 (17, 30)	22 (17, 30)					22 (17, 30)	22 (17, 30)	22 (17, 30)	22 (17, 30)					22 (17, 30)	22 (17, 30)	22 (17, 30)	22 (17, 30)
TP53+	TC4	n					8 (3, 12)	6 (2, 15)	2 (0, 4)	3 (2, 6)					0 (0, 0)	1 (0, 3)	0 (0, 0)	1 (0, 3)					0 (0, 1)	0 (0, 0)	4 (1, 8)	4 (2, 6)					0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC4	post_p					0.36 (0.18, 0.46)	0.38 (0.18, 0.49)	0.37 (0.22, 0.46)	0.31 (0.13, 0.46)					NA (NA, NA)	0.42 (0.39, 0.48)	NA (NA, NA)	0.44 (0.33, 0.49)					0.43 (0.43, 0.45)	NA (NA, NA)	0.36 (0.2, 0.47)	0.32 (0.15, 0.46)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC4	r_prob					0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TP53+	TC4	rate					0.143 (0.121, 0.289)	0.16 (0.094, 0.265)	0.211 (0.127, 1.225)	0.232 (0.128, 0.588)					NA (NA, NA)	0.23 (0, 0.703)	0.763 (0.763, 0.763)	0.15 (0.1, 1.135)					0.252 (0.076, 0.376)	NA (NA, NA)	0.177 (0.115, 0.369)	0.243 (0.134, 0.34)					0.08 (0.016, 0.085)	0.403 (0.403, 0.403)	0.144 (0.144, 0.144)	0.534 (0.534, 0.534)
TP53+	TC5	count					42	42	42	42					42	42	42	42					42	42	42	42					42	42	42	42
TP53+	TC5	time					21 (13, 32)	21 (13, 32)	21 (13, 32)	21 (13, 32)					21 (13, 32)	21 (13, 32)	21 (13, 32)	21 (13, 32)					21 (13, 32)	21 (13, 32)	21 (13, 32)	21 (13, 32)					21 (13, 32)	21 (13, 32)	21 (13, 32)	21 (13, 32)
TP53+	TC5	n					6 (2, 13)	7 (4, 10)	2 (0, 4)	5 (2, 10)					0 (0, 0)	1 (0, 2)	0 (0, 0)	1 (0, 2)					0 (0, 1)	0 (0, 0)	4 (1, 12)	4 (2, 8)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC5	post_p					0.36 (0.21, 0.47)	0.3 (0.16, 0.47)	0.43 (0.27, 0.49)	0.36 (0.16, 0.49)					NA (NA, NA)	0.44 (0.35, 0.48)	NA (NA, NA)	0.41 (0.36, 0.47)					0.45 (0.36, 0.49)	NA (NA, NA)	0.37 (0.18, 0.48)	0.33 (0.18, 0.49)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC5	r_prob					0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0 (0, 0)	0.38 (0.38, 0.38)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC5	rate					0.154 (0.108, 0.343)	0.149 (0.102, 0.227)	0.188 (0.109, 0.514)	0.152 (0.088, 0.322)					NA (NA, NA)	0.208 (0.064, 0.588)	NA (NA, NA)	0.233 (0.037, 1.219)					0.019 (0, 0.766)	NA (NA, NA)	0.187 (0.106, 0.567)	0.177 (0.111, 0.488)					0.166 (0.033, 1.866)	0.088 (0.058, 0.117)	0.174 (0.174, 0.174)	0 (0, 0)
TEfus+	TC1	count			4	4			4	4			4	4			4	4			4	4			4	4			4	4			4	4
TEfus+	TC1	time			26 (24, 33)	26 (24, 33)			26 (24, 33)	26 (24, 33)			26 (24, 33)	26 (24, 33)			26 (24, 33)	26 (24, 33)			26 (24, 33)	26 (24, 33)			26 (24, 33)	26 (24, 33)			26 (24, 33)	26 (24, 33)			26 (24, 33)	26 (24, 33)
TEfus+	TC1	n			1 (0, 4)	0 (0, 1)			2 (1, 5)	7 (4, 10)			0 (0, 1)	0 (0, 0)			0 (0, 0)	1 (1, 3)			2 (1, 4)	0 (0, 2)			8 (4, 10)	6 (4, 10)			0 (0, 2)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	post_p			0.44 (0.44, 0.44)	0.46 (0.45, 0.47)			0.37 (0.32, 0.47)	0.4 (0.28, 0.45)			0.47 (0.47, 0.47)	NA (NA, NA)			NA (NA, NA)	0.46 (0.46, 0.47)			0.46 (0.34, 0.48)	0.38 (0.37, 0.39)			0.23 (0.09, 0.39)	0.4 (0.19, 0.43)			0.45 (0.44, 0.45)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC1	r_prob			0.37 (0.37, 0.37)	0.22 (0.22, 0.22)			0.18 (0.18, 0.18)	0.09 (0.09, 0.09)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.18 (0.18, 0.18)	0.14 (0.14, 0.14)			0.12 (0.12, 0.12)	0.07 (0.07, 0.07)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	rate			0.079 (0.071, 0.088)	0.105 (0.103, 0.107)			0.222 (0.124, 0.348)	0.118 (0.097, 0.122)			0.079 (0.079, 0.079)	NA (NA, NA)			NA (NA, NA)	0.153 (0.044, 0.233)			0.212 (0.12, 0.554)	17.642 (3.788, 31.495)			0.191 (0.121, 0.493)	0.18 (0.144, 0.284)			0.15 (0.03, 0.27)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC2	count			21	21			21	21			21	21			21	21			21	21			21	21			21	21			21	21
TEfus+	TC2	time			22 (15, 33)	22 (15, 33)			22 (15, 33)	22 (15, 33)			22 (15, 33)	22 (15, 33)			22 (15, 33)	22 (15, 33)			22 (15, 33)	22 (15, 33)			22 (15, 33)	22 (15, 33)			22 (15, 33)	22 (15, 33)			22 (15, 33)	22 (15, 33)
TEfus+	TC2	n			2 (0, 3)	3 (1, 7)			2 (1, 4)	5 (3, 11)			2 (0, 5)	1 (0, 2)			0 (0, 0)	0 (0, 2)			4 (1, 6)	1 (0, 2)			5 (2, 13)	5 (2, 10)			0 (0, 1)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	post_p			0.44 (0.25, 0.49)	0.36 (0.24, 0.47)			0.44 (0.25, 0.47)	0.43 (0.18, 0.48)			0.32 (0.14, 0.49)	0.45 (0.33, 0.49)			NA (NA, NA)	0.39 (0.32, 0.42)			0.38 (0.21, 0.48)	0.46 (0.31, 0.49)			0.32 (0.19, 0.47)	0.42 (0.23, 0.48)			0.46 (0.46, 0.46)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC2	r_prob			0.25 (0.25, 0.25)	0.03 (0.03, 0.03)			0.41 (0.41, 0.41)	0.16 (0.16, 0.16)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.41 (0.41, 0.41)	0.29 (0.29, 0.29)			0.37 (0.37, 0.37)	0.21 (0.21, 0.21)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	rate			0.115 (0.019, 0.42)	0.173 (0.086, 0.34)			0.189 (0.082, 0.667)	0.155 (0.097, 0.229)			0.184 (0.076, 0.576)	0.191 (0.049, 0.357)			NA (NA, NA)	0.215 (0.09, 0.64)			0.164 (0.093, 0.324)	0.24 (0.125, 0.46)			0.166 (0.103, 0.727)	0.16 (0.113, 0.419)			0.13 (0, 0.799)	NA (NA, NA)			NA (NA, NA)	0 (0, 0)
TEfus+	TC3	count			21	21			21	21			21	21			21	21			21	21			21	21			21	21			21	21
TEfus+	TC3	time			24 (16, 32)	24 (16, 32)			24 (16, 32)	24 (16, 32)			24 (16, 32)	24 (16, 32)			24 (16, 32)	24 (16, 32)			24 (16, 32)	24 (16, 32)			24 (16, 32)	24 (16, 32)			24 (16, 32)	24 (16, 32)			24 (16, 32)	24 (16, 32)
TEfus+	TC3	n			2 (0, 2)	3 (1, 7)			2 (0, 4)	4 (2, 6)			4 (1, 10)	2 (1, 3)			0 (0, 0)	1 (0, 3)			2 (0, 4)	1 (0, 2)			4 (2, 7)	5 (2, 9)			0 (0, 1)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC3	post_p			0.38 (0.27, 0.47)	0.37 (0.2, 0.45)			0.42 (0.34, 0.48)	0.39 (0.17, 0.47)			0.33 (0.2, 0.42)	0.41 (0.38, 0.47)			NA (NA, NA)	0.43 (0.27, 0.47)			0.42 (0.32, 0.48)	0.47 (0.37, 0.49)			0.36 (0.16, 0.49)	0.31 (0.16, 0.43)			0.45 (0.45, 0.45)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC3	r_prob			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0 (0, 0)	0 (0, 0)			0.06 (0.06, 0.06)	0.07 (0.07, 0.07)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TEfus+	TC3	rate			0.172 (0.056, 0.439)	0.146 (0.077, 0.451)			0.142 (0.1, 0.393)	0.152 (0.106, 0.353)			0.165 (0.093, 0.276)	0.186 (0.074, 0.698)			0.411 (0.411, 0.411)	0.153 (0.043, 1.579)			0.167 (0.118, 0.379)	0.181 (0.099, 0.848)			0.162 (0.114, 0.387)	0.176 (0.09, 0.343)			0.151 (0.034, 0.196)	0 (0, 0)			0.281 (0.281, 0.281)	NA (NA, NA)
TEfus+	TC4	count			18	18			18	18			18	18			18	18			18	18			18	18			18	18			18	18
TEfus+	TC4	time			22 (19, 31)	22 (19, 31)			22 (19, 31)	22 (19, 31)			22 (19, 31)	22 (19, 31)			22 (19, 31)	22 (19, 31)			22 (19, 31)	22 (19, 31)			22 (19, 31)	22 (19, 31)			22 (19, 31)	22 (19, 31)			22 (19, 31)	22 (19, 31)
TEfus+	TC4	n			1 (1, 3)	2 (1, 7)			2 (1, 3)	5 (1, 9)			4 (1, 6)	2 (0, 4)			0 (0, 0)	2 (0, 4)			2 (1, 5)	0 (0, 3)			5 (3, 9)	3 (2, 6)			0 (0, 1)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC4	post_p			0.39 (0.34, 0.47)	0.37 (0.26, 0.45)			0.41 (0.24, 0.47)	0.42 (0.35, 0.49)			0.28 (0.19, 0.4)	0.39 (0.32, 0.47)			NA (NA, NA)	0.46 (0.34, 0.49)			0.37 (0.2, 0.45)	0.39 (0.32, 0.42)			0.38 (0.2, 0.46)	0.35 (0.22, 0.45)			0.44 (0.4, 0.47)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC4	r_prob			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0 (0, 0)	0 (0, 0)			0.06 (0.06, 0.06)	0.07 (0.07, 0.07)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TEfus+	TC4	rate			0.316 (0.123, 1.031)	0.189 (0.1, 0.267)			0.23 (0.032, 0.796)	0.145 (0.106, 0.361)			0.207 (0.108, 0.475)	0.172 (0.106, 0.527)			NA (NA, NA)	0.208 (0.102, 0.553)			0.281 (0.16, 0.582)	0.189 (0.124, 0.491)			0.165 (0.113, 0.303)	0.224 (0.149, 0.556)			0.12 (0, 0.272)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC5	count			18	18			18	18			18	18			18	18			18	18			18	18			18	18			18	18
TEfus+	TC5	time			24 (13, 31)	24 (13, 31)			24 (13, 31)	24 (13, 31)			24 (13, 31)	24 (13, 31)			24 (13, 31)	24 (13, 31)			24 (13, 31)	24 (13, 31)			24 (13, 31)	24 (13, 31)			24 (13, 31)	24 (13, 31)			24 (13, 31)	24 (13, 31)
TEfus+	TC5	n			1 (0, 4)	5 (2, 7)			2 (0, 4)	6 (4, 9)			2 (1, 7)	1 (0, 2)			0 (0, 0)	1 (0, 3)			2 (1, 4)	1 (0, 4)			3 (1, 6)	5 (3, 7)			0 (0, 1)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC5	post_p			0.43 (0.31, 0.48)	0.3 (0.19, 0.41)			0.43 (0.27, 0.49)	0.33 (0.15, 0.45)			0.36 (0.2, 0.46)	0.42 (0.34, 0.47)			NA (NA, NA)	0.4 (0.39, 0.45)			0.41 (0.34, 0.48)	0.42 (0.31, 0.45)			0.33 (0.16, 0.45)	0.37 (0.23, 0.49)			0.49 (0.49, 0.49)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC5	r_prob			0 (0, 0)	0.38 (0.38, 0.38)			0 (0, 0)	0.38 (0.38, 0.38)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0.29 (0.29, 0.29)			0 (0, 0)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC5	rate			0.229 (0.086, 1.262)	0.167 (0.114, 0.338)			0.164 (0.065, 0.761)	0.141 (0.084, 0.279)			0.328 (0.131, 1.253)	0.15 (0.091, 0.384)			NA (NA, NA)	0.268 (0.099, 1.271)			0.152 (0.106, 0.411)	0.17 (0.095, 0.418)			0.269 (0.133, 0.595)	0.163 (0.105, 0.274)			0.187 (0.03, 0.591)	NA (NA, NA)			NA (NA, NA)	0 (0, 0)
PI3K+	TC1	count		3		3		3		3		3		3		3		3		3		3		3		3		3		3		3		3
PI3K+	TC1	time		23 (14, 31)		23 (14, 31)		23 (14, 31)		23 (14, 31)		23 (14, 31)		23 (14, 31)		23 (14, 31)		23 (14, 31)		23 (14, 31)		23 (14, 31)		23 (14, 31)		23 (14, 31)		23 (14, 31)		23 (14, 31)		23 (14, 31)		23 (14, 31)
PI3K+	TC1	n		2 (1, 8)		2 (0, 4)		5 (4, 11)		6 (4, 7)		0 (0, 0)		0 (0, 1)		1 (0, 1)		0 (0, 1)		2 (0, 2)		1 (0, 2)		0 (0, 0)		6 (6, 7)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC1	post_p		0.43 (0.41, 0.44)		0.46 (0.44, 0.48)		0.46 (0.23, 0.49)		0.31 (0.3, 0.33)		NA (NA, NA)		NA (NA, NA)		0.34 (0.32, 0.35)		0.47 (0.47, 0.47)		NA (NA, NA)		0.43 (0.42, 0.45)		NA (NA, NA)		0.42 (0.38, 0.47)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC1	r_prob		0.22 (0.22, 0.22)		0.22 (0.22, 0.22)		0.13 (0.13, 0.13)		0.09 (0.09, 0.09)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.14 (0.14, 0.14)		0.14 (0.14, 0.14)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC1	rate		0.096 (0.094, 0.219)		0.201 (0.093, 0.31)		0.121 (0.095, 0.21)		0.156 (0.113, 0.246)		NA (NA, NA)		0.949 (0.949, 0.949)		0.254 (0.243, 0.265)		0.146 (0.146, 0.146)		0.278 (0.194, 0.362)		0.252 (0.195, 0.31)		NA (NA, NA)		0.147 (0.111, 0.154)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC2	count		46		46		46		46		46		46		46		46		46		46		46		46		46		46		46		46
PI3K+	TC2	time		24 (17, 33)		24 (17, 33)		24 (17, 33)		24 (17, 33)		24 (17, 33)		24 (17, 33)		24 (17, 33)		24 (17, 33)		24 (17, 33)		24 (17, 33)		24 (17, 33)		24 (17, 33)		24 (17, 33)		24 (17, 33)		24 (17, 33)		24 (17, 33)
PI3K+	TC2	n		7 (4, 12)		4 (2, 9)		5 (2, 10)		5 (3, 10)		0 (0, 0)		1 (0, 4)		0 (0, 2)		1 (0, 2)		1 (0, 2)		1 (0, 3)		0 (0, 0)		5 (2, 9)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC2	post_p		0.27 (0.1, 0.44)		0.37 (0.2, 0.48)		0.36 (0.17, 0.47)		0.35 (0.18, 0.48)		NA (NA, NA)		0.39 (0.3, 0.49)		0.42 (0.35, 0.49)		0.42 (0.26, 0.47)		0.44 (0.33, 0.49)		0.4 (0.3, 0.49)		0.48 (0.48, 0.48)		0.36 (0.21, 0.49)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC2	r_prob		0.03 (0.03, 0.03)		0.03 (0.03, 0.03)		0.07 (0.07, 0.07)		0.16 (0.16, 0.16)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0.21 (0.21, 0.21)		0.21 (0.21, 0.21)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC2	rate		0.146 (0.095, 0.316)		0.144 (0.088, 0.289)		0.164 (0.104, 0.48)		0.156 (0.106, 0.309)		NA (NA, NA)		0.178 (0.093, 0.671)		0.166 (0, 0.393)		0.186 (0.076, 2.725)		0.206 (0, 0.924)		0.192 (0.067, 0.481)		0.104 (0.021, 0.295)		0.147 (0.106, 0.412)		NA (NA, NA)		NA (NA, NA)		0.162 (0.162, 0.162)		0 (0, 0)
PI3K+	TC3	count		39		39		39		39		39		39		39		39		39		39		39		39		39		39		39		39
PI3K+	TC3	time		25 (17, 31)		25 (17, 31)		25 (17, 31)		25 (17, 31)		25 (17, 31)		25 (17, 31)		25 (17, 31)		25 (17, 31)		25 (17, 31)		25 (17, 31)		25 (17, 31)		25 (17, 31)		25 (17, 31)		25 (17, 31)		25 (17, 31)		25 (17, 31)
PI3K+	TC3	n		5 (2, 11)		3 (1, 8)		6 (3, 10)		4 (2, 9)		0 (0, 0)		2 (0, 3)		1 (0, 2)		2 (0, 4)		0 (0, 2)		1 (0, 3)		0 (0, 0)		4 (2, 9)		0 (0, 0)		0 (0, 1)		0 (0, 0)		0 (0, 0)
PI3K+	TC3	post_p		0.28 (0.12, 0.42)		0.4 (0.26, 0.47)		0.31 (0.19, 0.45)		0.38 (0.22, 0.45)		NA (NA, NA)		0.41 (0.31, 0.49)		0.44 (0.37, 0.48)		0.46 (0.34, 0.49)		0.45 (0.4, 0.46)		0.44 (0.37, 0.49)		NA (NA, NA)		0.33 (0.19, 0.47)		NA (NA, NA)		NA (NA, NA)		0.48 (0.48, 0.48)		NA (NA, NA)
PI3K+	TC3	r_prob		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC3	rate		0.161 (0.105, 0.432)		0.124 (0.076, 0.879)		0.182 (0.114, 0.295)		0.169 (0.122, 0.371)		NA (NA, NA)		0.12 (0.064, 0.405)		0.18 (0, 0.471)		0.148 (0.01, 0.464)		0.319 (0, 0.75)		0.178 (0.059, 0.387)		0.091 (0.069, 0.114)		0.191 (0.102, 0.74)		NA (NA, NA)		0.13 (0, 1.694)		2.794 (2.794, 2.794)		0.355 (0.355, 0.355)
PI3K+	TC4	count		43		43		43		43		43		43		43		43		43		43		43		43		43		43		43		43
PI3K+	TC4	time		25 (18, 35)		25 (18, 35)		25 (18, 35)		25 (18, 35)		25 (18, 35)		25 (18, 35)		25 (18, 35)		25 (18, 35)		25 (18, 35)		25 (18, 35)		25 (18, 35)		25 (18, 35)		25 (18, 35)		25 (18, 35)		25 (18, 35)		25 (18, 35)
PI3K+	TC4	n		8 (3, 13)		4 (1, 8)		7 (3, 16)		5 (2, 9)		0 (0, 0)		2 (0, 5)		1 (0, 3)		1 (0, 3)		0 (0, 1)		1 (0, 2)		0 (0, 0)		3 (2, 10)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC4	post_p		0.33 (0.13, 0.42)		0.37 (0.23, 0.46)		0.36 (0.15, 0.48)		0.35 (0.21, 0.47)		NA (NA, NA)		0.44 (0.33, 0.48)		0.43 (0.25, 0.48)		0.42 (0.33, 0.47)		0.46 (0.37, 0.47)		0.42 (0.25, 0.47)		NA (NA, NA)		0.36 (0.15, 0.47)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC4	r_prob		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC4	rate		0.129 (0.087, 0.196)		0.148 (0.086, 0.402)		0.147 (0.107, 0.348)		0.184 (0.105, 0.418)		NA (NA, NA)		0.148 (0.083, 0.444)		0.256 (0.059, 0.477)		0.165 (0.068, 0.682)		0.275 (0.04, 1.687)		0.203 (0.041, 1.225)		0.078 (0.016, 0.14)		0.184 (0.097, 0.527)		0.291 (0.291, 0.291)		0.421 (0.421, 0.421)		0.445 (0.295, 0.595)		0.534 (0.534, 0.534)
PI3K+	TC5	count		66		66		66		66		66		66		66		66		66		66		66		66		66		66		66		66
PI3K+	TC5	time		17 (11, 32)		17 (11, 32)		17 (11, 32)		17 (11, 32)		17 (11, 32)		17 (11, 32)		17 (11, 32)		17 (11, 32)		17 (11, 32)		17 (11, 32)		17 (11, 32)		17 (11, 32)		17 (11, 32)		17 (11, 32)		17 (11, 32)		17 (11, 32)
PI3K+	TC5	n		8 (4, 14)		4 (2, 9)		6 (3, 11)		5 (3, 9)		0 (0, 0)		1 (0, 4)		0 (0, 2)		1 (0, 2)		1 (0, 2)		1 (0, 3)		0 (0, 0)		4 (2, 10)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC5	post_p		0.29 (0.1, 0.45)		0.39 (0.17, 0.48)		0.35 (0.16, 0.46)		0.37 (0.2, 0.48)		NA (NA, NA)		0.42 (0.35, 0.49)		0.43 (0.32, 0.47)		0.45 (0.36, 0.48)		0.45 (0.32, 0.49)		0.41 (0.32, 0.48)		NA (NA, NA)		0.4 (0.21, 0.48)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC5	r_prob		0.38 (0.38, 0.38)		0.38 (0.38, 0.38)		0.33 (0.33, 0.33)		0.38 (0.38, 0.38)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC5	rate		0.137 (0.085, 0.265)		0.147 (0.074, 0.326)		0.163 (0.105, 0.368)		0.151 (0.103, 0.325)		0.065 (0.013, 0.118)		0.178 (0.066, 0.439)		0.28 (0.075, 0.791)		0.164 (0, 0.626)		0.155 (0, 1.583)		0.196 (0.036, 0.669)		0.081 (0, 49.977)		0.156 (0.092, 0.363)		0.451 (0.082, 0.977)		NA (NA, NA)		0.179 (0.036, 0.322)		0.196 (0, 1.111)